A5061572565- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Nutrition and Health in Aging
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- Frailty in Older Adults
- Occupational and environmental lung diseases
Aarhus University
2020
The University of Melbourne
2016
Tumor testing of colorectal cancers (CRC) for mismatch repair (MMR) deficiency is an effective approach to identify carriers germline MMR gene mutation (Lynch syndrome). The aim this study was in two cohorts population-based CRC utilizing a combination tumor and approaches.
Objectives Immunohistochemistry for DNA mismatch repair proteins is used to screen Lynch syndrome in individuals with colorectal carcinoma (CRC). Although solitary loss of PMS2 expression indicative carrying a germline mutation , previous studies reported MLH1 some cases. We determined the prevalence mutations large cohort CRC demonstrating expression. Design This study included 88 affected PMS2-deficient from Colon Cancer Family Registry Cohort. Germline analysis (long-range PCR and...