A5021390393- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Global Cancer Incidence and Screening
- BRCA gene mutations in cancer
- Forecasting Techniques and Applications
- Coral and Marine Ecosystems Studies
- Coastal and Marine Management
- Decision-Making and Behavioral Economics
- Cancer Genomics and Diagnostics
- Marine and fisheries research
- Asthma and respiratory diseases
- Temporomandibular Joint Disorders
- Poisoning and overdose treatments
- Complex Systems and Decision Making
- Cardiac Arrest and Resuscitation
- Gastric Cancer Management and Outcomes
- Risk Perception and Management
- Multiple and Secondary Primary Cancers
- Allergic Rhinitis and Sensitization
- Dermatological and COVID-19 studies
- Colorectal Cancer Surgical Treatments
- Opioid Use Disorder Treatment
- Global Health Workforce Issues
- Delphi Technique in Research
- Helicobacter pylori-related gastroenterology studies
The University of Melbourne
2011-2024
The Royal Melbourne Hospital
2011
Peter MacCallum Cancer Centre
2011
Cancer Council Victoria
1994-2011
Monash University
1988-2006
Royal Children's Hospital
1994
The Alfred Hospital
1988
University of California, San Francisco
1986
University of Colorado Boulder
1978-1980
Elicitation of expert opinion is important for risk analysis when only limited data are available. Expert often elicited in the form subjective confidence intervals; however, these prone to substantial overconfidence. We investigated influence elicitation question format, particular number steps procedure. In a 3-point procedure, an asked lower limit, upper and best guess, two limits creating interval some assigned level (e.g., 80%). our 4-step experts were also realistic but no was...
Expert judgements are essential when time and resources stretched or we face novel dilemmas requiring fast solutions. Good advice can save lives large sums of money. Typically, experts defined by their qualifications, track record experience [1], [2]. The social expectation hypothesis argues that more highly regarded experienced will give better advice. We asked to predict how they perform, peers on sets questions. results indicate the way regard each other is consistent, but unfortunately,...
<h3>Abstract</h3> <b>Objective</b>: To determine which factors measured in childhood predict asthma adult life. <b>Design</b>: Prospective study over 25 years of a birth cohort initially studied at the age 7. <b>Setting</b>: Tasmania, Australia. Subjects—1494 men and women surveyed 1991-3 when aged 29 to 32 (75% random stratified sample from 1968 Tasmanian survey children born 1961 school Tasmania). <b>Main outcome measures</b>: Self reported or wheezy breathing previous 12 months (current...
Expert judgments are a necessary part of environmental management. Typically, experts defined by their qualifications, track record, professional standing, and experience. We outline the limitations conventional definitions expertise describe how these requirements can sometimes exclude people with useful knowledge. The frailties biases in expert interact social status afforded to produce that both unassailable wrong. Several approaches may improve rigor judgments; they include widening set...
Abstract Metric data on 200 sacra of known sex, age and race are analyzed to determine the usefulness conventional observations for determining sex in this bone. Results univariate analysis show that significant differences sacrum involve primarily top portion bone both whites blacks. However, measurements curvature important sample A new index relating SI body sacral breadth is proposed as more useful classifying bones by than indices involving other measurements. Discriminant shows can be...
Tumor testing of colorectal cancers (CRC) for mismatch repair (MMR) deficiency is an effective approach to identify carriers germline MMR gene mutation (Lynch syndrome). The aim this study was in two cohorts population-based CRC utilizing a combination tumor and approaches.
Summary Background Asthma is more prevalent among males in childhood, but females report higher rates adulthood. The reasons are unknown; although it has been hypothesized that hormonal factors may explain this sex‐dependent risk of adult‐onset asthma. Objective To determine whether a woman's reproductive history or use oral contraceptives associated with Methods In 1991–1993, we surveyed 681 women aged 29–32 years randomly sampled from participants first at age 7 by the 1968 Tasmanian...
Summary. The aim of this analysis was to examine the degree which a life time prevalence asthma in 7‐year‐old child is statistically associated with atopic conditions child, and parental asthma, hay fever smoking. In 1968, 8585 children who were born 1961 attending school Tasmania surveyed. This comprised 99% eligible population. history 7‐year‐olds 16.2% (males 19.0%, females 13.2%). Multiple logistic regression showed that being male (odds ratio [OR] 1.56; confidence interval 1.30–1.86),...
A pilot study was conducted to determine whether any relationship exists between mutagenicity of a women's uterine cervical mucus and her current smoking status. Cervical fluids obtained from 78 premenopausal women seen July 1983 March 1984 at the University California, San Francisco Dysplasia (and diethylstilbestrol) Clinic or in private practice were tested for by means Ames-Salmonella microsomal test. Of 36 smokers, 14 (39%) had positive tests as compared 5 42 nonsmokers (12%). The odds...
A risk-stratified approach to colorectal cancer (CRC) screening could result in a more acceptable balance of benefits and harms, be cost-effective.To determine the effect consultation general practice using computerised risk assessment decision support tool (Colorectal RISk Prediction, CRISP) on risk-appropriate CRC screening.Randomised controlled trial 10 practices Melbourne, Australia, from May 2017 2018.Participants were recruited consecutive sample patients aged 50-74 years attending...
Our objective was to determine screening practices of unaffected people in the general population at moderately increased and potentially high risk colorectal cancer (CRC) because their family history disease. A total 1,627 participants Australasian Colorectal Cancer Family Registry study were classified into two CRC categories, according strength We calculated proportion that adhered national guidelines by age group for each familial category. carried out a multinomial logistic regression...
Management responsibilities for the system of marine national parks and sanctuaries declared in Victoria, Australia 2002 have created imperatives robust, scientifically defendable approaches to identifying threats valued ecological attributes parks, setting management priorities, developing monitoring systems. We are a protocol risk assessment that has due regard perception risks by individuals, ensures stakeholder values an intrinsic part decision making. The inclusive transparent provides...
Protected area management effectiveness (PAME) evaluation is increasingly undertaken to evaluate governance, assess conservation outcomes and inform evidence-based of protected areas (PAs). Within PAME, quantitative approaches biodiversity are now emerging, where biological monitoring data directly assessed against (numerically defined) condition categories (termed assessments). However, more commonly qualitative assessments employed in which use descriptive evaluated largely with expert...
Many Australians at average risk of colorectal cancer (CRC) are undergoing unnecessary colonoscopic screening, while many increased getting inadequate screening. The aim this study was to test different ways communicating the risks and benefits CRC as part development a prediction (CRISP) tool.General practice patients were shown five presentations for hypothetical ‘average’ ‘increased’ cases asked choose screening method they would undergo. Associations explored between presentation type...
Abstract The great variability and complexity of sacral morphology has led to some confusion over the separate influences phylogeny, population differences, sexual dimorphism. Principal component analysis Cartesian coordinates taken on alae one hundred human sacra reveals that allometric growth accounts for most variation in extent orientation this region (termed basality). Sex differences related functional contribution pelvic cavity account remainder variability. requirement extrastability...
Abstract We asked if twin birth influences the DNA methylation of subsequent siblings. measured whole blood using HumanMethylation450 array for siblings from two and family studies in Australia Korea. compared means correlations between pairs born before a (BT siblings), on either side (B/AT pairs) after (AT siblings). For genome-wide average methylation, correlation AT (r ) was larger than BT both studies, meta-analysis, r = 0.46 (95% CI: 0.26, 0.63) −0.003 −0.30, 0.29) ( P 0.02). B/AT were...
Australia and New Zealand have the highest incidence rates of colorectal cancer worldwide. In there is significant unwarranted variation in screening due to low uptake immunochemical faecal occult blood test, poor identification individuals at increased risk cancer, over-referral average for colonoscopy. Our pre-trial research has developed a novel Colorectal RISk Prediction (CRISP) tool, which could be used implement precision primary care. This paper describes protocol phase II multi-site...