A5040683204- Metabolism and Genetic Disorders
- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- Metabolomics and Mass Spectrometry Studies
- Renal and related cancers
- Adipokines, Inflammation, and Metabolic Diseases
- Erythropoietin and Anemia Treatment
- Pluripotent Stem Cells Research
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Renal cell carcinoma treatment
- Biochemical and Molecular Research
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Hypoxia, and Metabolism
- Diet and metabolism studies
- Adenosine and Purinergic Signaling
- Renal Diseases and Glomerulopathies
- Alcohol Consumption and Health Effects
- Neurological and metabolic disorders
- Drug Transport and Resistance Mechanisms
University of Pittsburgh
2023-2025
Children's Hospital of Pittsburgh
2023
University of Utah
1963
Vascularization plays a critical role in organ maturation and cell type development. Drug discovery, mimicry, ultimately transplantation hinge on achieving robust vascularization of vitro engineered organs. Here, focusing human kidney organoids, we overcame this hurdle by combining induced pluripotent stem (iPSC) line containing an inducible ETS translocation variant 2 (ETV2) (a transcription factor playing endothelial development) that directs differentiation vitro, with non-transgenic iPSC...
The renal tubular epithelial cells (RTECs) are particularly vulnerable to acute kidney injury (AKI). While fatty acids the preferred energy source for RTECs via acid oxidation (FAO), FAO-mediated H2O2 production in mitochondria has been shown be a major of oxidative stress. We have previously that mitochondrial flavoprotein, long-chain acyl-CoA dehydrogenase (LCAD), which catalyzes key step FAO, directly produces vitro. Further, we showed LCAD becomes hyposuccinylated during AKI. Here,...
Significance Statement In this study, we demonstrate that a common, low-cost compound known as octanedioic acid (DC 8 ) can protect mice from kidney damage typically caused by ischemia-reperfusion injury or the chemotherapy drug cisplatin. This seems to enhance peroxisomal activity, which is responsible for breaking down fats, without adversely affecting mitochondrial function. DC not only affordable and easy administer but also effective. These encouraging findings suggest could potentially...
ABSTRACT Proximal tubular epithelial cells (PTECs) are particularly vulnerable to acute kidney injury (AKI). While fatty acids the preferred energy source for PTECs via acid oxidation (FAO), FAO-mediated H 2 O production in mitochondria has been shown be a major of oxidative stress. We have previously that mitochondrial flavoprotein, long-chain acyl-CoA dehydrogenase (LCAD), which catalyzes key step FAO, directly produces vitro . Further we established loss lysine deacylase, Sirtuin 5 (...
Journal of the American Society Nephrology 34(11S):p 116-117, November 2023. | DOI: 10.1681/ASN.20233411S1116d