A5101514404- Escherichia coli research studies
- Viral gastroenteritis research and epidemiology
- Plant Pathogens and Fungal Diseases
- Mycotoxins in Agriculture and Food
- Vibrio bacteria research studies
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Antibiotic Resistance in Bacteria
- Probiotics and Fermented Foods
- Plant Reproductive Biology
- Blood groups and transfusion
- Plant Genetic and Mutation Studies
- Glycosylation and Glycoproteins Research
- Toxin Mechanisms and Immunotoxins
- Microbial infections and disease research
- Monoclonal and Polyclonal Antibodies Research
- Photosynthetic Processes and Mechanisms
- Diabetes and associated disorders
- Erythrocyte Function and Pathophysiology
- Animal Diversity and Health Studies
- Antibiotic Use and Resistance
- Bee Products Chemical Analysis
- Bioactive natural compounds
- Antimicrobial Peptides and Activities
- Protease and Inhibitor Mechanisms
Washington University in St. Louis
2011-2024
Shah Abdul Latif University
2012-2021
Tamil Nadu Veterinary and Animal Sciences University
2020
Plant (United States)
2017
National Quarantine Station
2017
ABSTRACT Enterotoxigenic Escherichia coli (ETEC) is a leading cause of death due to diarrheal illness among young children in developing countries, and there currently no effective vaccine. Many elements ETEC pathogenesis are still poorly defined. Here we demonstrate that YghJ, secreted antigen identified immunoproteomic studies using convalescent patient sera, required for efficient access small intestinal enterocytes the optimal delivery heat-labile toxin (LT). Furthermore, YghJ highly...
Enterotoxigenic Escherichia coli (ETEC) is a major cause of morbidity and mortality due to infectious diarrhea in developing countries for which there presently no effective vaccine. A central challenge ETEC vaccinology has been the identification conserved surface antigens formulate broadly protective Here, we demonstrate that EatA, an immunogenic secreted serine protease ETEC, contributes virulence by degrading MUC2, protein present small intestinal mucous layer, removal this barrier vitro...
Enterotoxigenic Escherichia coli (ETEC) infections are highly prevalent in developing countries, where clinical presentations range from asymptomatic colonization to severe cholera-like illness. The molecular basis for these varied presentations, which may involve strain-specific virulence features as well host factors, has not been elucidated. We demonstrate that, when challenged with ETEC strain H10407, originally isolated a case of illness, blood group A human volunteers developed...
Because O blood group has been associated with more severe cholera infections, it hypothesized that toxin (CT) may bind non-O antigens of the intestinal mucosae, thereby preventing efficient interaction target GM1 gangliosides required for uptake and activation cyclic adenosine monophosphate (cAMP) signaling in epithelia. Herein, we show after exposure to CT, human enteroids expressing exhibited marked increase cAMP relative cells derived from A individuals. Likewise, using CRISPR/Cas9...
Enterotoxigenic Escherichia coli (ETEC) cause hundreds of millions cases infectious diarrhea annually, predominantly in children from low-middle income regions. Notably, children, as well volunteers challenged with ETEC, diarrheal severity is significantly increased blood group A (bgA) individuals. EtpA, a secreted glycoprotein adhesin that functions lectin to promote critical interactions between ETEC and glycans on intestinal epithelia for effective bacterial adhesion toxin delivery. EtpA...
ABSTRACT Enterotoxigenic Escherichia coli (ETEC) strains are among the most common causes of diarrheal illness worldwide. These pathogens disproportionately afflict children in developing countries, where they cause substantial morbidity and responsible for hundreds thousands deaths each year. Although these organisms important targets enteric vaccines, development efforts to date have centered on a subset plasmid-encoded fimbrial adhesins known as colonization factors heat-labile toxin...
ABSTRACT At present, there is no vaccine for enterotoxigenic Escherichia coli (ETEC), an important cause of diarrheal illness. Nevertheless, recent microbial pathogenesis studies have identified a number molecules produced by ETEC that contribute to its virulence and are novel antigenic targets complement canonical approaches. EtpA secreted two-partner adhesin conserved within the pathovar. interacts with tips flagella promote bacterial adhesion, toxin delivery, intestinal colonization...
ABSTRACT The cryptococcal capsule is a critical virulence factor of an important pathogen, but little known about how it associated with the cell or released into environment. Two mutants lacking PBX1 and PBX2 were found to shed reduced amounts polysaccharide glucuronoxylomannan (GXM). Nuclear magnetic resonance, composition, physical analyses showed that material was normal mass slightly enriched in xylose. In contrast previous reports, this contained no glucose. Notably, fibers pbx Δ...
Enterotoxigenic
This study investigated oxyclozanide, a salicylanilide anthelmintic, as an alternative treatment for Methicillin-resistant Staphylococcus aureus (MRSA) in bovine mastitis. With conventional treatments facing challenges due to antibiotic resistance, oxyclozanide demonstrated promising vitro antimicrobial effect against MRSA isolates. The minimal inhibitory concentration (MIC) ranged from 0.5 1.0 μg/ml, indicating its efficacy. Oxyclozanide’s mechanism involved disrupting the transmembrane...
The present study was conducted to prepare and evaluate the herbo-mineral emulgel formulation containing Curcuma longa, Datura metel, Aloe vera calcium hydroxide against bovine clinical mastitis. Extracts of selected plants were screened for phytochemicals. In Vitro antimicrobial screening herbal extracts isolated bacterial strains performed by Agar disc-diffusion method. activities polyherbals (Curcuma metel vera) gentamicin sulphate (antibiotic agent) Staphylococcus aureus, Streptococcus...
Aim: Multidrug resistance (MDR) is a major public health problem worldwide. The aim of this study was to assess the prevalence, levels antimicrobial susceptibility and extended-spectrum beta lactamase (ESBL) production by Escherichia coli O157: H7.
 Methodology: A cross sectional performed total 116 stool samples were collected from children aged ≤ 5 years presenting diarrhoea hospital located at district Khairpur. E. H7 isolated on Sorbitol MacConkey agar isolates initially...