A5111221992- Congenital heart defects research
- Cardiovascular Function and Risk Factors
- Single-cell and spatial transcriptomics
- Advanced Fluorescence Microscopy Techniques
- Birth, Development, and Health
Wellcome Sanger Institute
2024
Wellcome/MRC Cambridge Stem Cell Institute
2024
University of Cambridge
2024
Abstract Developmental dynamics encompass both the specification of cell types and their spatial organisation into multicellular niches. Here we harness power single-cell multiomics to unravel embryonic foetal cardiac tissue niches, which lead development a new tool, TissueTypist. We reveal that cardiac-resident macrophages likely originate from yolk sac, forming heterogeneous subsets. CX3CR1 + with microglia-like profile localise in sinoatrial node, may contribute axon guidance for...
Throughout our lifetime, each beat of the heart requires coordinated action multiple cardiac cell types. Understanding biology, its intricate microenvironments, and mechanisms that govern their function in health disease are crucial to designing novel therapeutical behavioral interventions. Recent advances single-cell spatial omics technologies have significantly propelled this understanding, offering insights into cellular diversity complex interactions tissue. This review provides a...