A5074306630- Cardiomyopathy and Myosin Studies
- Congenital heart defects research
- Genomics and Rare Diseases
- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- Traditional Chinese Medicine Analysis
- Plant-based Medicinal Research
- Cardiovascular Health and Disease Prevention
- Adipokines, Inflammation, and Metabolic Diseases
- Williams Syndrome Research
- Nitric Oxide and Endothelin Effects
- Traditional Chinese Medicine Studies
- Genetics, Bioinformatics, and Biomedical Research
- Lipoproteins and Cardiovascular Health
- Blood properties and coagulation
- Cardiovascular Function and Risk Factors
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Peking Union Medical College Hospital
2024
National Heart Centre Singapore
2020-2021
Abstract Background Emerging data suggested that lipoprotein(a) [Lp(a)] is an independent risk factor for atherosclerotic cardiovascular disease. Previous studies indicated fibrinogen (Fib) had synergetic effect on Lp(a)‐induced events. However, combined impact of Fib and Lp(a) ischemic stroke has not been elucidated. Methods In this prospective study, we consecutively enrolled 8263 patients with stable coronary artery diseases (CAD) from 2011 to 2017. Patients were categorized into three...
Abstract Background Family history has traditionally been an essential part of clinical care to assess health risks. However, declining sequencing costs have precipitated a shift towards genomics-first approaches in population screening programs rendering the value family unknown. We evaluated utility incorporating information for genomic selection. Methods To ascertain relationship between histories on such population-level initiatives, we analysed whole genome sequences 1750 research...
To assess the genetic architecture of hypertrophic cardiomyopathy (HCM) in patients predominantly Chinese ancestry.We sequenced HCM disease genes Singaporean (n=224) and controls (n=3634), compared findings with additional populations White cohorts (n=6179), performed vitro functional studies.Singaporean had significantly fewer confidently interpreted variants (pathogenic/likely pathogenic: 18%, P<0.0001) but an excess uncertain significance (24%, P<0.0001), as to Whites 31%, significance:...
Endothelin-1 (ET-1) is an endogenous vasoconstrictor implicated in coronary artery disease (CAD) and diabetes. This study aimed to determine the prognostic value of ET-1 patients with stable CAD under different glucose metabolism states.
Bioinformatics is an interdisciplinary field that develops methods and software tools for understanding biological data, in particular when the data sets are large complex. As of science, bioinformatics combines biology, computer information engineering, mathematics statistics to analyze interpret data. has been used silico analyses queries using mathematical statistical techniques. includes studies use programming as part their methodology, well a specific analysis pipelines repeatedly...