A5009165843- Hepatitis Viruses Studies and Epidemiology
- Hepatitis C virus research
- Viral gastroenteritis research and epidemiology
- Liver Disease and Transplantation
- Systemic Lupus Erythematosus Research
- Endoplasmic Reticulum Stress and Disease
- Hepatitis B Virus Studies
- Viral Infections and Immunology Research
- RNA regulation and disease
Paul Ehrlich Institut
2018-2024
Every year, there are about 20 Mio hepatitis E virus (HEV) infections and 60,000 deaths that associated with HEV worldwide. At the present, exists no specific therapy for HEV. The natural compound silvestrol has a potent antiviral effect against (−)-strand RNA-virus Ebola virus, also (+)-strand RNA viruses Corona-, Picorna-, Zika virus. inhibitory on spread is due to an inhibition of DEAD-box helicase eIF4A, which required unwind structured 5′-untranslated regions (UTRs). This leads impaired...
Background and aimsThe Hepatitis E virus hijacks the endosomal system for its release. These structures are highly dependent on cholesterol. Hence, this study investigates impact of HEV cholesterol-metabolism, effect intracellular cholesterol content HEV-release potential cholesterol-modulators to serve as antivirals.MethodsIntracellular cholesterol-content cells was modulated impacts were monitored using qPCR, Western blot, microscopy, virus-titration density-gradient centrifugation....
Although HEV represents a worldwide public health problem with 20 million infections and 44,000 deaths per year, there are still no specific antivirals available many aspects of the viral life cycle not well understood. Here, we identify guanylate binding protein 1 (GBP1) as restriction factor affecting HEV.
A peculiar feature of the hepatitis E virus (HEV) is its reliance on exosomal route for viral release. Genomic replication mediated via polyprotein pORF1, yet little known about subcellular localization.
ABSTRACT Hepatitis E virus (HEV) poses a global threat, which currently remains understudied in terms of host interactions. Epidermal growth factor receptor (EGFR) plays multifaceted roles viral pathogenesis, impacting host-cell entry, replication, and host-defense modulation. On the one hand, EGFR signaling emerged as major driver innate immunity; on other crosstalk between HEV requires deeper analysis. We therefore aimed to dissect receptor’s involvement life cycle. In persistently...