A5001698068- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Distributed systems and fault tolerance
- Advanced Database Systems and Queries
- Contact Dermatitis and Allergies
- Advanced Data Storage Technologies
- Distributed and Parallel Computing Systems
- Asthma and respiratory diseases
- Parallel Computing and Optimization Techniques
- Monetary Policy and Economic Impact
- Data Management and Algorithms
- Gear and Bearing Dynamics Analysis
- Business Process Modeling and Analysis
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Physics and Engineering Research Articles
- Digital Innovation in Industries
- Corporate Governance and Management
- Italy: Economic History and Contemporary Issues
- Real-Time Systems Scheduling
- Network Security and Intrusion Detection
- Optimization and Search Problems
- Digitalization, Law, and Regulation
- Tribology and Lubrication Engineering
- Scientific Computing and Data Management
Paul Ehrlich Institut
2015-2025
Fraunhofer Institute for Wind Energy Systems
2011-2022
The University of Adelaide
2022
Leibniz University Hannover
2019-2020
University of Münster
1994-2019
Fraunhofer Society
2012-2018
Global Climate Forum
2017-2018
Freie Universität Berlin
2015-2018
European Commission
2015-2018
European Media Laboratory (Germany)
2001-2018
Myeloid blood cells are largely resistant to infection with human immunodeficiency virus type 1 (HIV-1). Recently, it was reported that Vpx from HIV-2/SIVsm facilitates of these by counteracting the host restriction factor SAMHD1. Here, we independently confirmed interacts SAMHD1 and targets for ubiquitin-mediated degradation. We found Vpx-mediated degradation rendered primary monocytes highly susceptible HIV-1 infection; a T17A mutation, defective binding degradation, did not show this...
A DNA aptamer structure is the basis of a molecular machine that can be instructed to grab or release human blood-clotting factor α-thrombin, depending on operator sequence addressing it. In picture structure, which assumes conformation characterized by two stacked guanine quadruplex structures, linked thrombin (gray ellipse).
We studied the influence of eight nonleguminous grassland plant species belonging to two functional groups (grasses and forbs) on composition soil denitrifier communities in experimental microcosms over consecutive years. Denitrifier community was analyzed by terminal restriction fragment length polymorphism (T-RFLP) PCR-amplified nirK gene fragments coding for copper-containing nitrite reductase. The impact factors (plant group, species, sampling time, interactions between them) structure...
Abstract Allergen detection and quantification is an essential part of allergen management as practiced by food manufacturers. Recently, protein MS methods (in particular, multiple reaction monitoring experiments) have begun to be adopted the community provide alternative technique ELISA PCR methods. analysis proteins in foods provides additional challenges analyst, both terms experimental design methodology: (1) choice analyte, including multiplexing simultaneously detect several...
Laboratory measurements of the response Particle Measuring Systems, Inc., 2DC probe have been conducted to characterize counting and sizing errors for spherical particles. Measurements shadow threshold intensity a Meteorological Service Canada (MSC) varied from approximately 30% 51%, depending on photodiode, averaged 46% central 16 photodiodes. Depth-of-field are quite sensitive this threshold, which is nominally considered as 50% probe. Response times also significantly, 0.44 0.90 μs. depth...
Exported proteases of Helicobacter pylori (H. pylori) are potentially involved in pathogen-associated disorders leading to gastric inflammation and neoplasia. By comprehensive sequence screening the H. proteome for predicted secreted proteases, we retrieved several candidate genes. We detected caseinolytic activities such which released independently from type IV secretion system encoded by cag pathogenicity island (cagPAI). Among these, found serine protease HtrA (Hp1019), was previously...
Abstract SAMHD1 is a critical restriction factor for HIV-1 in non-cycling cells and its antiviral activity regulated by T592 phosphorylation. Here, we show that dephosphorylation at controlled during the cell cycle, occurring M/G 1 transition proliferating cells. Using several complementary proteomics biochemical approaches, identify phosphatase PP2A-B55α responsible rendering antivirally active. specifically targeted holoenzymes mitotic exit, line with observations key exit mammalian...
This paper presents three survey-based uncertainty indicators, which constitute further developments of similar, already existing measures. Their main merits are that they can be computed on the basis publicly available time series, rather than hard-to-acquire micro data, and derived from assessments actors in a multitude economic sectors, just single one, makes them particularly suitable to assess more comprehensively impact activity. Empirical analysis shows indicators counter-cyclical...
Every year, there are about 20 Mio hepatitis E virus (HEV) infections and 60,000 deaths that associated with HEV worldwide. At the present, exists no specific therapy for HEV. The natural compound silvestrol has a potent antiviral effect against (−)-strand RNA-virus Ebola virus, also (+)-strand RNA viruses Corona-, Picorna-, Zika virus. inhibitory on spread is due to an inhibition of DEAD-box helicase eIF4A, which required unwind structured 5′-untranslated regions (UTRs). This leads impaired...
The amplitude, frequency and number of oscillating movements have a significant impact on the possible damage modes rolling bearings. Changes in amplitude change both fatigue wear risk raceways. In order to properly calculate lifetime an bearing, estimate surface-induced design test programs for such bearings, it is necessary understand characteristics movements. This paper presents comprehensive method analysis time series data including position loads. applied simulated time-series IWT...
Abstract The power control of wind turbines is usually realized via a change in the pitch angle rotor blades. Pitching facilitates exact and reliable deceleration when required. Pitch movements can moreover be used for load control. One these methods called individual (IPC). IPC controls blades individually brings about significant reduction fatigue loads extreme placed on structural components, while at same time reducing yield turbine only slightly. lower reduce material costs, thus, cost...
Allergen detection methods support food labeling and quality assessment at the allergen component level of preparations used for allergy diagnosis immunotherapy (AIT). Commonly applied enzyme-linked immunosorbent assay (ELISA) requires animal antibodies but potentially shows batch variations. We developed synthetic aptamers as alternative binders in to meet replacement, reduction, refinement (3R) principle on protection science. ssDNA were specifically selected against major peanut Ara h 1...
The self-assembly properties of DNA make it an ideal choice for the construction nanomachines such as tweezers. Because function individual units, they need to be studied on single-molecule level. From single-pair FRET investigations, we show that "open" tweezers exist in a single conformation with minimal efficiency, whereas upon addition "closing strand", three conformations are observed, which averaged out ensemble measurements.
Summary Background Food allergy to cherry occurs throughout Europe, typically with restricted oral reactions in the central and northern parts but frequent systemic Mediterranean region. Previous studies have demonstrated insufficient sensitivity of commercially available extract reagents diagnosis allergy. Objective To assess diagnostic performance specific IgE tests based on recombinant allergens comparison an extract‐based assay skin prick test (SPT). A secondary objective was analyse...
Various logging and recovery techniques for centralized transaction-oriented database systems under performance aspects are described discussed. The classification of functional principles that has been developed in a companion paper is used as terminological basis. In the main sections, set analytic models introduced evaluated order to compare characteristics nine different with respect four key parameters other less influence. Finally, results model evaluation well limitations themselves
Food allergy to pea (Pisum sativum) has been rarely studied in children at the clinical and molecular levels.