A5007572667- Retinal Diseases and Treatments
- Retinopathy of Prematurity Studies
- Neonatal Respiratory Health Research
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Retinal and Macular Surgery
- Retinal Imaging and Analysis
- Neonatal Health and Biochemistry
- Neonatal and fetal brain pathology
- Optical Coherence Tomography Applications
- melanin and skin pigmentation
- Glaucoma and retinal disorders
- Genomic variations and chromosomal abnormalities
- Glioma Diagnosis and Treatment
- Genomics and Rare Diseases
- Reconstructive Facial Surgery Techniques
- Ocular Disorders and Treatments
- Neuroblastoma Research and Treatments
- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Corneal Surgery and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Ocular Surface and Contact Lens
- Ocular Oncology and Treatments
- Autoimmune Neurological Disorders and Treatments
Meyer Children's Hospital
2010-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2022-2024
University of Florence
2003-2022
Azienda Ospedaliero-Universitaria Careggi
2008-2022
Ghent University Hospital
2022
Azienda Sanitaria Unità Locale di Reggio Emilia
2022
Children's Hospital of Philadelphia
2022
Uniwersytecki Szpital Dziecięcy
2018
Children's Clinical University Hospital
2018
Camera di Commercio di Firenze
2008
Oxygen-induced retinopathy (OIR) is a model for human of prematurity (ROP). In OIR mice, this study determined whether blockade β-adrenergic receptors (β-ARs) with propranolol influences retinal levels proangiogenic factors, vascularization, and blood-retinal barrier (BRB) breakdown.Propranolol was administered subcutaneously picropodophyllin (PPP) intraperitoneally. Intravitreal injections vascular endothelial growth factor (VEGF) were performed. Messengers β-ARs, VEGF, its receptors, IGF-1...
Despite new therapeutic approaches have improved the prognosis of newborns with retinopathy prematurity (ROP), an unfavourable structural and functional outcome still remains high. There is high pressure to develop drugs prevent treat ROP. increasing enthusiasm for anti-VEGF drugs, but angiogenic inhibitors selective abnormal blood vessels would be considered as optimal treatment. In animal experimental model proliferative retinopathy, we recently demonstrated that pharmacological blockade...
Background: Oral propranolol reduces retinopathy of prematurity (ROP) progression, although not safely. Propranolol 0.1% eye micro-drops administered to newborns with stage 2 ROP are well-tolerated, but sufficiently effective. Methods: A multi-center open-label trial was conducted assess the safety and efficacy 0.2% in 1 ROP. The progression disease evaluated serial ophthalmologic examinations. Hemodynamic, respiratory, biochemical parameters, plasma levels were monitored. Demographic...
Monocentric retrospective case series to describe clinical and molecular peculiarities in a of pediatric patients attempting possible genotype-phenotype correlation. We included 13 from 7 unrelated families (ages 1-18) with biallelic pathogenic likely variants RDH12 gene. For all our segregation analyses were performed their parents affected siblings. According cooperation, underwent complete ophtalmic examination imaging full field standard electroretinography (ffERG), spectral domain...
In Brief Purpose: To report the evolution of diabetic macular edema (DME) after extensive panretinal photocoagulation in patients with Type 1 diabetes exhibiting florid proliferative retinopathy (FPDR). Methods: This retrospective observational case series comprised 17 eyes 10 consecutive (8 women and 2 men). All exhibited FPDR combined severe DME, all underwent photocoagulation. The visual acuity progression were evaluated. DME during follow-up was assessed by fluorescein angiography...
Abstract Background Treatment strategies for Retinoblastoma (RB), the most common primary intraocular tumor in children, have evolved over past few decades and chemoreduction is currently popular treatment strategy. Despite success, systemic chemotherapeutic has relevant toxicity, especially pediatric population. Antiangiogenic therapy thus been proposed as a valuable alternative malignancies, particolar RB. Indeed, it shown that vessel density correlates with both local invasive growth...
Objectives: Laser therapy is effective in the treatment of severe forms retinopathy prematurity (ROP), and aggressive posterior ROP (APROP), but always damages retina. We report our preliminary findings seven premature infants with complicated or APROP who were treated intravitreal bevacizumab (IVB) as first line monotherapy rescue combined laser treatment. Methods: studied retrospectively preterm infants, affected by (n = 4) pre-threshold 3). Infants IVB (0.625 mg; Avastin®, Roche, Basel,...
Background: Biallelic pathogenic variants in MFRP and PRSS56 genes can be responsible for nanophthalmos (NO) or posterior microphthalmos (PM). This study describes detailed clinical molecular findings a series of five patients affected by PM from four unrelated families.Materials Methods: All underwent complete ophthalmological genetic evaluation. For proper deep phenotyping multimodal instrumental approach was used all cases: B-scan ultrasound, spectral domain optical coherence tomography...
Introduction BRPF1 gene on 3p26-p25 encodes a protein involved in epigenetic regulation, through interaction with histone H3 lysine acetyltransferases KAT6A and KAT6B of the MYST family. Heterozygous pathogenic variants are associated Intellectual Developmental Disorder Dysmorphic Facies Ptosis (IDDDFP), characterized by global developmental delay, intellectual disability, language dysmorphic facial features. The reported ocular involvement includes strabismus, amblyopia, refraction errors....
Retinopathy of prematurity (ROP) still represents one the leading causes visual impairment in childhood. Systemic propranolol has proven to be effective reducing ROP progression preterm newborns, although safety was not sufficiently guaranteed. On contrary, topical treatment with eye micro-drops at a concentration 0.1% had an optimal profile newborns ROP, but disease if administered advanced stage (during 2). The aim present protocol is evaluate and efficacy 0.2% more precocious (stage 1). A...
Aim of the present study is to evaluate relationship between genetic and phenotypic data in a series patients affected by grade I II foveal hypoplasia with stable fixation good visual acuity using multimodal imaging techniques. All underwent complete clinical instrumental assessment including structural Optical Coherence Tomography (OCT), OCT Angiography Adaptive Optics (AO) imaging. Central macular thickness (CMT), inner nuclear layer (INL), vessel density superficial capillary plexus were...
To evaluate retinal reperfusion, anastomosis, and compensation following radial optic neurotomy for ischemic nonperfused central vein occlusion.
Studies performed in animal models of corneal neovascularization suggested the possible efficacy a treatment with propranolol. Corneal is one most feared complications Stevens-Johnson syndrome that frequently involves ocular surface. We report first 2 patients severe neo-vascularization treated different degrees success, propranolol eye drops.Two complicating syndrome, not responsive to steroids and cyclosporine, were drops.Corneal was detected by ophthalmoscopic evaluation.Topical drops at...
Background. Recent explorative studies suggest that propranolol reduces retinopathy of prematurity (ROP) progression, but the short-term effects treatment at one year corrected age have not been extensively evaluated. Methods. A multi-center retrospective observational cohort study was conducted to assess physical development and refractive outcome infants with prior ROP treated propranolol. Forty-nine were compared an equal number patients who did receive any therapy represent control...
Background Congenital Stationary Night Blindness (CSNB) constitutes a group of non-progressive retinal disorders characterized by disturbances in scotopic vision and/or delay adaptation to darkness, as well low visual acuity, myopia, nystagmus, and strabismus. Color fundus appearance tend be normal. To date, several CACNA1F gene variants have been linked CSNB phenotype but only few reports focused on the optic nerve this disease.Materials Methods Twelve patients underwent standard...
Purpose of this course is to review the principles that guide diagnosis and classification macular diseases, new options available for purpose. Among treatments modalities, photodynamic therapy (PDT) has been recently introduced in clinical practice treating subfoveal choroidal neovascularization (CNV). In age-related degeneration (AMD), eyes which classic CNV components covers at least 50% entire lesion, called predominantly lesions, benefit from a substantial reduction rate moderate visual...