A5009565744- Neonatal Respiratory Health Research
- Respiratory viral infections research
- Congenital Diaphragmatic Hernia Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Pneumonia and Respiratory Infections
- Neonatal Health and Biochemistry
- Crystallization and Solubility Studies
- Respiratory Support and Mechanisms
- Neonatal and fetal brain pathology
- Bacterial Infections and Vaccines
- Vaccine Coverage and Hesitancy
- Retinopathy of Prematurity Studies
- Neuroscience of respiration and sleep
- Epilepsy research and treatment
- Tracheal and airway disorders
- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Virology and Viral Diseases
- Tuberculosis Research and Epidemiology
- Influenza Virus Research Studies
- Glycogen Storage Diseases and Myoclonus
- Infectious Diseases and Tuberculosis
- Gestational Diabetes Research and Management
- Vascular Malformations and Hemangiomas
Meyer Children's Hospital
2014-2025
University of Florence
2003-2016
Regione Toscana
2016
Azienda Ospedaliero-Universitaria Careggi
2009-2015
Purpose: To investigate the feasibility of a study based on treatment with topiramate (TPM) added to moderate hypothermia in newborns hypoxic ischemic encephalopathy (HIE).Materials and methods: Multicenter randomized controlled trial. Term precocious metabolic, clinical electroencephalographic (EEG) signs HIE were selected according their amplified integrated EEG pattern receive either TPM (10 mg/kg once day for first three days life) plus or alone. Safety was assessed by monitoring...
Objective: Maternal diabetes increases the risk of perinatal mortality and morbidity, but maintenance antenatal normal glucose serum prevents majority neonatal complications. The aim our study is to compare metabolomic profile infants gestational diabetic mothers (IGDMs) that healthy evaluate if differences remain despite a strict control diabetes.Methods: We performed metabolomics in cord sampled from 30 term IGDMs 40 controls recording occurrence most frequent complications IGDMs.Results:...
To evaluate the performance of a non-contact infrared thermometer (NCIT) in comparison with digital axillary (DAT) and tympanic thermometers (ITT) population healthy at term preterm newborns nursed incubators.1 level III maternity hospital, its intensive neonatal care unit.119 70 incubators were consecutively enrolled. Exclusion criteria unstable/critical conditions, polymalformative congenital syndromes severe syndromes.Body temperature readings prospectively collected. Each participant...
Background: Oral propranolol reduces retinopathy of prematurity (ROP) progression, although not safely. Propranolol 0.1% eye micro-drops administered to newborns with stage 2 ROP are well-tolerated, but sufficiently effective. Methods: A multi-center open-label trial was conducted assess the safety and efficacy 0.2% in 1 ROP. The progression disease evaluated serial ophthalmologic examinations. Hemodynamic, respiratory, biochemical parameters, plasma levels were monitored. Demographic...
The possible correlation between the mean platelet volume (MPV) and occurrence of bronchopulmonary dysplasia (BPD) intraventricular hemorrhage (IVH) in a cohort preterm infants was assessed. We studied with gestational age <30 weeks. Enrolled were divided into BPD no-BPD groups IVH no-IVH groups. MPV evaluated at birth 24 to 48 hours life. measured similar groups, but life higher than group (11.1 ± 0.9 versus 10.8 fL, p = 0.033) multivariate analysis demonstrated that >11 fL increases...
Highlights•RSV seasonality in 2023/2024 aligned with pre-pandemic patterns but peaked earlier.•RSV hospitalization incidence was higher than levels•Severe RSV risk (e.g. ICU similar to seasons•Ongoing surveillance is important as new preventive tools are introducedAbstractBackgroundRSV epidemiology disrupted by the COVID-19 pandemic. This study investigates season Tuscany, Italy, assess trends and of RSV-associated hospitalizations compared prior post-pandemic seasons.MethodsWe analyzed...
To provide epidemiological data on pertussis in a highly vaccinated paediatric population, focusing the age of infected children.We analysed from regional hospital discharge database children hospitalised for Tuscany, Italy, January 2000 to December 2012.A total 279 cases were recorded. The majority infants (75.6%), who had highest rate complications (24.2%) any group and crude mortality 9.47 per 1000. overall hospitalisation decreased significantly during study period, 4.23 2.82 100 000,...
Immune-mediated pathogenesis has been suggested for idiopathic sensorineural hearing loss. Recent studies have investigated the relationship between loss and autoantibodies against inner ear antigens. We conducted a prospective, observational study in series of pediatric patients affected by Autoantibodies (anti-Cogan peptide, anti-connexin 26, anti-DEP1/CD148 anti-reovirus), previously described serum with Cogan's syndrome, were detected our population. The characteristics children whose...
A newborn with unresectable kaposiform hemangioendothelioma associated Kasabach Merritt phenomenon, unresponsive to vincristine and prednisone, received second‐line treatment propranolol at a dose of 2 mg/kg/day, starting months life continued for 13 months. There was only slight reduction in tumor mass, but measurement levels showed extremely low plasma concentrations. The progressively increased 3.5 leading substantial increase clinically relevant reduction. This case highlights the...
Background. Great variability in enteral feeding practices for very preterm (<32 weeks gestational age-GA) and low birth weight infants (VLBW; ≤1,500g) have been reported. We aimed to describe data on Tuscany (Italy), where a network of 6 donor milk banks is place. Methods. A 4-year (2012-2015) observational study was performed analyzing the database "TIN Toscane online" VLBW infants. The covers all 25 hospitals with neonatal unit. Results. Data concerning beginning nutrition were available...
Objectives: To assess the agreement of transcutaneous bilirubin (TcB) measurement with Bilicare™ System in comparison to TcB measured JM-103™ and total serum (TSB).Methods: Caucasian infants gestational age ≥35 weeks non-hemolytic jaundice received both devices. TSB was also obtained at risk phototherapy.Results: We studied 458 measuring JM-103™, correlating results TSB. The mean difference ± 2SD between 2.02 4.46 mg/dL decreased from 2.88 3.17 1.20 4.55, −0.95 4.58 mild, moderate high...
Abstract Aim The goal of this study was to compare the current guidelines on diagnosis and treatment paediatric community‐acquired pneumonia ( CAP ) in developing developed countries. Methods A literature search performed consulting M edline, E mbase, C urrent ontents, N ational G uideline learinghouse ochrane database, from J anuary 2000 arch 2013. Results Twelve were selected: six countries Major discrepancies between approaches recommended by covering revealed. also highlighted...
SUMMARY To evaluate measles incidence and its relevant changes over a 14-year period (2000–2014), we analysed data from the regional hospital discharge database on children adults hospitalized in Tuscany, Italy. A total of 181 paediatric 413 adult cases were identified. Despite all efforts towards elimination, observed that overall hospitalization rates for living Tuscany globally increased 0·45 to 0·85/100 000 during study ( P = 0·001) showing fluctuations due periodic outbreaks. Data...
Retinopathy of prematurity (ROP) still represents one the leading causes visual impairment in childhood. Systemic propranolol has proven to be effective reducing ROP progression preterm newborns, although safety was not sufficiently guaranteed. On contrary, topical treatment with eye micro-drops at a concentration 0.1% had an optimal profile newborns ROP, but disease if administered advanced stage (during 2). The aim present protocol is evaluate and efficacy 0.2% more precocious (stage 1). A...
Abstract Aim We surveyed care practices for critically ill very preterm infants admitted to neonatal intensive units (NICUs) in the International Network Evaluating Outcomes Neonates (iNeo) identify differences relevant outcome comparisons. Methods conducted an online survey on and with severe intracranial haemorrhage (ICH). The was distributed 2015 representatives of 390 NICUs 11 countries. Survey replies were compared network incidence death ICH born between 23 0/7 28 6/7 weeks gestation...