A5074855325- Alzheimer's disease research and treatments
- Graphene and Nanomaterials Applications
- Supramolecular Self-Assembly in Materials
- Molecular Biology Techniques and Applications
- Genomics and Chromatin Dynamics
- Monoclonal and Polyclonal Antibodies Research
- Dementia and Cognitive Impairment Research
- Science, Research, and Medicine
- Breast Cancer Treatment Studies
- Neuroscience and Neuropharmacology Research
- Cancer Genomics and Diagnostics
- Brain Metastases and Treatment
- Genomics and Phylogenetic Studies
- HER2/EGFR in Cancer Research
Stanford University
2024-2025
Stratford University
2024
Northwestern University
2020
Breast cancer is a highly heterogeneous disease whose prognosis and treatment as defined by the expression of three receptors—oestrogen receptor (ER), progesterone human epidermal growth factor 2 (HER2; encoded ERBB2)—is insufficient to capture full spectrum clinical outcomes therapeutic vulnerabilities. Previously, we demonstrated that transcriptional genomic profiles define eleven integrative subtypes with distinct outcomes, including four ER+ increased risk relapse decades after...
Abstract Breast cancer, characterized by considerable heterogeneity, showcases genetic and epigenetic variability among individual tumors their constituent cells. Notably, this intratumoral heterogeneity (ITH) can drive clonal evolution therapy resistance, particularly in Human Epidermal Growth Factor Receptor 2 (HER2)-positive cancers. Despite the efficacy of HER2-targeted therapies, many patients develop resulting poor prognosis. This study aims to elucidate dynamic interplay between...
Abstract Extrachromosomal DNA (ecDNA) are circular, megabase-scale regions of the genome found outside canonical chromosomes and characterized by high copy-number frequent oncogene amplification. They implicated in tumorigenesis, therapeutic resistance, shortened survival for patients across multiple cancer types. Existing tools to identify predict ecDNA structures limited low throughput, sensitivity enrichment-based assays or computational methods using whole-genome sequencing data. Recent...
Abstract The four breast cancer subtypes—luminal A, luminal B, HER2-overexpressing, and triple-negative (TNBC) – are classified based on gene expression profiles of hormone receptors (HRs) (estrogen receptor (ER) progesterone (PR)) human epidermal growth factor 2 (HER2/ERBB2). Negative status is known to be associated with more aggressive cancer. Compared other subtypes, the HR-negative TNBC HER2-overexpressing subtypes characterized by high rates recurrence a notable increase in brain...
Abstract Introduction Amyloid‐beta oligomers (AβOs) accumulate in Alzheimer's disease and may instigate neuronal pathology cognitive impairment. We examined the ability of a new probe for molecular magnetic resonance imaging (MRI) to detect AβOs vivo, we tested behavioral impact injected rabbits, species with an amino acid sequence that is nearly identical human sequence. Methods Intracerebroventricular (ICV) injection stabilized was performed. Rabbits were probed AβO accumulation using...