Luca Castelli
A5065844156- Particle physics theoretical and experimental studies
- Particle Detector Development and Performance
- Dark Matter and Cosmic Phenomena
- Legal and Labor Studies
- Multiple Sclerosis Research Studies
- T-cell and B-cell Immunology
- Bone and Dental Protein Studies
- Superconducting Materials and Applications
- Bone Metabolism and Diseases
- Muscle metabolism and nutrition
- Peripheral Neuropathies and Disorders
- Galectins and Cancer Biology
- Immune Response and Inflammation
- Taxation and Legal Issues
- Hematopoietic Stem Cell Transplantation
- Virus-based gene therapy research
- RNA regulation and disease
- Immune Cell Function and Interaction
- International Science and Diplomacy
- Systemic Lupus Erythematosus Research
- Muon and positron interactions and applications
- Autophagy in Disease and Therapy
- Phagocytosis and Immune Regulation
- Cross-Border Cooperation and Integration
- Cell death mechanisms and regulation
Istituto Nazionale di Fisica Nucleare, Sezione di Roma I
2023-2025
Sapienza University of Rome
2024-2025
University of Trieste
2022-2024
Istituto Nazionale di Fisica Nucleare, Sezione di Trieste
2022-2024
Istituto Nazionale di Fisica Nucleare, Sezione di Padova
2022-2024
University of Padua
2022-2024
Stockholm University
2024
European Organization for Nuclear Research
2024
LIP - Laboratory of Instrumentation and Experimental Particle Physics
2024
University of Birmingham
2024
Abstract The Muon Collider is one of the most promising future collider facilities with potential to reach multi-TeV center-of-mass energy and high luminosity. Due significant Higgs boson production cross section in muon-antimuon collisions at such energies, offers an excellent opportunity for in-depth exploration properties. It holds capability significantly advance our understanding sector a very level precision. However, presence beam-induced background resulting from decay beam muons...
Arachidonic acid metabolites, the eicosanoids, are key mediators of allergen-induced airway inflammation and remodeling in asthma. The availability free arachidonate cells for subsequent eicosanoid biosynthesis is controlled by phospholipase A(2)s (PLA(2)s), most notably cytosolic PLA(2)-alpha. 10 secreted PLA(2)s (sPLA(2)s) have also been identified, but their function generation poorly understood. We investigated role group X sPLA(2) (sPLA(2)-X), with highest vitro cellular...
Abstract Objective To test the association of osteopontin (OPN) polymorphisms with systemic lupus erythematosus (SLE). Methods The coding 5′ and 3′ flanking regions OPN gene were scanned for by denaturing high‐performance liquid chromatography. A case–control study was performed in 394 Italian SLE patients 479 matched controls. serum levels determined enzyme‐linked immunosorbent assay 40 124 controls, mean compared between different genotypes. Results Among 13 detected single‐nucleotide...
In the path towards a muon collider with center of mass energy 10 TeV or more, stage at 3 emerges as an appealing option. Reviewing physics potential such is main purpose this document. order to outline progression performances across stages, few sensitivity projections for higher are also presented. There many opportunities probing new collider. Some them in common extensively documented case CLIC stage, and include measuring Higgs trilinear coupling testing possible composite nature boson...
To counteract muscle mass, strength and power loss during aging, to study age-related change of neuromuscular manifestation fatigue in relation nutritional supplementation. randomized controlled double-blind study. Twice-daily consumption for 12 weeks an Essential Amino Acids (EAA)-based multi-ingredient supplement containing EAA, creatine, vitamin D Muscle Restore Complex®. 38 healthy elderly subjects (8 male, 30 female; age: 68.91±4.60 years; body weight: 69.40±15.58 kg; height: 1.60±0.09...
A multi-TeV Muon Collider produces a significant amount of Higgs bosons allowing precise measurements its couplings to Standard Model fundamental particles. Moreover, boson pairs are produced with relevant cross-section, the determination second term potential by measuring double production cross section and therefore trilinear self-coupling term. This contribution aims give an overview accuracies expected for initial stage at s=3TeV integrated luminosity 1ab−1 target center-of-mass energy...
Muon collisions are considered a promising mean for exploring the energy frontier, leading to detailed study of possible feasibility issues. Beam intensities order 1012 muons per bunch needed achieve necessary luminosity, generating high flux secondary and tertiary particles from decay that reach both machine elements detector region. To limit impact this background on physics performance tungsten shieldings have been studied. A learning-based approach geometry optimization these will be discussed.
Muon collisions are considered a promising means for exploring the energy frontier, leading to detailed study of possible feasibility challenges. Beam intensities order 1012 muons per bunch needed achieve necessary luminosity, generating high flux secondary and tertiary particles from decay that reach both machine elements detector region. To limit impact this background on physics performance, tungsten shieldings have been studied. A learning-based approach geometry optimization these will...
A multi-TeV muon collider produces a significant amount of Higgs bosons allowing for precise measurements its couplings to Standard Model fundamental particles. Moreover, boson pairs are produced with relevant cross-section, the determination second term potential by measuring double production cross-section and therefore trilinear self-coupling term. This contribution aims give an overview measurement accuracies expected initial stage at s=3TeV integrated luminosity 1ab−1 target...
One of the challenges multi-TeV muon collider is mitigating effects beam-induced background. The primary contribution to this background has been identified as decay products beams. If not properly managed, these decays arriving at detector could limit its performance. This paper presents sources, strategies currently for mitigation, and ongoing activities in regard.
This document is comprised of a collection updated preliminary parameters for the key parts muon collider. The follow on from October 2023 Tentative Parameters Report. Particular attention has been given to regions facility that are believed hold greater technical uncertainty in their design and have strong impact cost power consumption facility. data collected collaborative spreadsheet transferred overleaf.
Abstract Several sets of data indicate that ICOS regulates cytokine production in activated T cells, but is less effective on naïve cells. This work evaluates function human CD4 + cells through an assessment the effect soluble forms and CD28 physiological ligands activation driven by anti‐CD3 mAb. strikingly potentiated secretion IL‐2, IFN‐γ, IL‐10, TNF‐α, not IL‐4, promoted optimal stimulation CD3+CD28, it was key switching‐factor when received suboptimal CD3+CD28 or CD3 alone presence...
A muon collider would enable the big jump ahead in energy reach that is needed for a fruitful exploration of fundamental interactions. The challenges producing collisions at high luminosity and 10 TeV centre mass are being investigated by recently-formed International Muon Collider Collaboration. This Review summarises status recent advances on colliders design, physics detector studies. aim to provide global perspective field outline directions future work.
Abstract The Fas death receptor is expressed by activated lymphocytes and involved in switching‐off the immune response. Its inherited defects cause auto‐immune lymphoproliferative syndrome. Impaired function may also play a role other diseases, such as multiple sclerosis type 1 diabetes mellitus. aim of this work was to evaluate T cells from patients with chronic inflammatory demyelinating polyneuropathy (CIDP). We evaluated Fas‐induced apoptosis T‐cell lines 27 CIDP, 12 acute (AIDP), 110...