A5081318399- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Carcinogens and Genotoxicity Assessment
- Metabolomics and Mass Spectrometry Studies
- Bacterial Identification and Susceptibility Testing
- Microbial Community Ecology and Physiology
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- Helicobacter pylori-related gastroenterology studies
- Hip disorders and treatments
- CRISPR and Genetic Engineering
- Orthopaedic implants and arthroplasty
- Dental materials and restorations
- Cancer-related molecular mechanisms research
- Hip and Femur Fractures
- Bacteriophages and microbial interactions
- Microbial Natural Products and Biosynthesis
- Additive Manufacturing and 3D Printing Technologies
- RNA and protein synthesis mechanisms
- Probiotics and Fermented Foods
- Bone Tissue Engineering Materials
- Biosensors and Analytical Detection
- Gene expression and cancer classification
- Inflammatory Bowel Disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
Pennsylvania State University
2022-2025
Nanjing Medical University
2017-2021
Litron Laboratories (United States)
2020
Rochester Institute of Technology
2019
Clostridioides difficile, a major cause of antibiotic-associated diarrhea, is suppressed by the gut microbiome, but precise mechanisms are not fully described. Through meta-analysis 12 human studies, we designed synthetic fecal microbiota transplant (sFMT1) reconstructing microbial networks negatively associated with C. difficile colonization. This lab-built 37-strain consortium formed functional community suppressing in vitro and animal models. Using sFMT1 as tractable model system, find...
<title>Abstract</title> Glucuronidation is an important detoxification pathway that operates in balance with gastrointestinal microbial β-glucuronidase (GUS) enzymes can regenerate active metabolites from their glucuronidated forms. Although significant progress has been made characterizing GUS enzymes, methods to comprehensively define the glucuronidome – collection of remain limited. In this study we employed pattern-filtering data science approaches alongside untargeted LC-MS/MS...
The aim of the present study was to investigate application 3D printing (3DP) rapid prototyping (RP) technique‑assisted percutaneous fixation in treatment femoral intertrochanteric fracture (ITF) using proximal nail anti‑rotation (PFNA). A total 39 patients with unstable ITF were included current study. Patients divided into two groups: 19 examined computed tomography scanning and underwent PFNA SDP‑RP whereas other 20 conventional treatment. Anatomical data converted from Digital Imaging...
MultiFlow® DNA Damage-p53, γH2AX, Phospho-Histone H3 is a miniaturized, flow cytometry-based assay that provides genotoxic mode of action information by distinguishing clastogens, aneugens, and nongenotoxicants. Work to date has focused on the p53-competent human cell line TK6. While mammalian genotoxicity assays typically supply exogenous metabolic activation in form concentrated rat liver S9, this less-than-ideal approach for several reasons, including 3Rs considerations. Here, we describe...
Are touchscreen devices a public health risk for the transmission of pathogenic bacteria, especially those that are resistant to antibiotics? To investigate this, we embarked on project aimed at isolating and identifying bacteria antibiotics from screens smartphones. Touchscreen have become ubiquitous in society, it is important evaluate potential risks they pose towards health, as pertains harboring antibiotics. Sixteen were initially isolated which five unique (four Staphylococcus species...
Abstract Titanium alloy is a clinically approved material for bone substitution. Although three‐dimensional printing (3DP) fabrication technique can build up porous Ti scaffolds with the designed shape and microstructure, biomechanical performance of 3DP still need to be improved increase reliability osseointegration capacity. To address this issue, rabbit marrow clot (MC) used modify by stem cell delivery microenvironment decoration inside pores these scaffolds. Moreover, were built using...
Abstract Nasopharyngeal carcinoma (NPC) is a rare malignancy, with the unique geographical and ethnically characteristics of distribution. Gene chip bioinformatics have been employed to reveal regulatory mechanisms in current functional genomics. However, practical solution addressing unresolved aspects microarray data processing analysis long pursuit. This study developed new method improve accuracy identifying key biomarkers, namely Unit Gamma Measurement (UGM), accounting for multiple...
ABSTRACT Background Synthetic microbial communities offer an opportunity to conduct reductionist research in tractable model systems. However, deriving abundances of highly related strains within these is currently unreliable. 16S rRNA gene sequencing does not resolve abundance at the strain level, standard methods for analysis shotgun metagenomic do account ambiguous mapping between closely strains, and other such as quantitative PCR (qPCR) scale poorly are resource prohibitive complex...
Inflammatory bowel disease (IBD) is an important risk factor for gastrointestinal cancers. Inflammation and other carcinogenesis-related effects at distal, tissue-specific sites require further study. In order to better understand if systemic genotoxicity associated with IBD, we exposed mice dextran sulfate sodium salt (DSS) measured the incidence of micronucleated cells (MN) Pig-a mutant phenotype in blood erythrocyte populations. one study, 8-week-old male CD-1 were 0, 1, 2, 3 or 4% w/v...
Clostridioides difficile, a major cause of antibiotic associated diarrhea, is suppressed by the gut microbiome, but precise mechanisms are not fully described. Through meta-analysis 12 human studies, we designed synthetic fecal microbiota transplant (sFMT1) reconstructing microbial networks negatively with C. difficile colonization. This lab-built 37 strain consortia formed functional community suppressing in vitro and animal models. Using sFMT1 as tractable model system, find that bile acid...