A5102814816- Mast cells and histamine
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Eosinophilic Disorders and Syndromes
- Advanced Breast Cancer Therapies
- Cell Adhesion Molecules Research
- Pediatric health and respiratory diseases
- Chronic Lymphocytic Leukemia Research
- Lysosomal Storage Disorders Research
- Urticaria and Related Conditions
- Lung Cancer Research Studies
- Asthma and respiratory diseases
- Immunodeficiency and Autoimmune Disorders
- Respiratory Support and Mechanisms
- Diabetes Treatment and Management
- Respiratory viral infections research
- Antibiotics Pharmacokinetics and Efficacy
- Neonatal Respiratory Health Research
- Allergic Rhinitis and Sensitization
- Metabolism, Diabetes, and Cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Metabolism and Genetic Disorders
- PI3K/AKT/mTOR signaling in cancer
- Click Chemistry and Applications
Indiana University – Purdue University Indianapolis
2009-2024
Eli Lilly (United States)
2019-2024
Richard L. Roudebush VA Medical Center
2022-2024
Quality Enhancement Research Initiative
2024
Tulane University
2019
Children's Hospital of New Orleans
2019
Ochsner Medical Center
2019
Indiana University School of Medicine
2009-2016
University of North Carolina at Chapel Hill
2008-2013
Indiana University
2013
Metachromatic leukodystrophy (MLD) is an inherited demyelinating disease that causes progressive neurologic deterioration, leading to severe motor disability, developmental regression, seizures, blindness, deafness, and death. The presents as a late-infantile, juvenile, or adult form. Hematopoietic stem cell transplantation has been shown slow progression. purpose of this longitudinal study was evaluate long-term treatment outcomes after unrelated donor umbilical cord blood (UCB) in...
A structural and biochemical study is presented concerning the agglutination of gametic flagella, initial step in mating reaction Chlamydomonas reinhardtii. An alteration distribution intramembranous particles revealed by freeze-fracturing flagella membranes shown to accompany differentiation both types. The isolation electrophoretic analysis flagellar mastigonemes are reported; no differences can be detected when membrane or mastigoneme glycoproteins from vegative cells compared, nor two...
Abstract In MONARCH 3, continuous dosing of abemaciclib with an aromatase inhibitor (AI) conferred significant clinical benefit to postmenopausal women HR+, HER2− advanced breast cancer. We report data for clinically prognostic subgroups: liver metastases, progesterone receptor status, tumor grade, bone-only disease, ECOG performance and treatment-free interval (TFI) from additional 12-month follow-up (after final progression-free survival [PFS] readout). the intent-to-treat population,...
Infantile Krabbe disease, a rare neurodegenerative disorder that leads to rapid demyelination, dysmyelination, and death in the first 2 years of life, is responsive treatment with umbilical cord blood transplantation provided patient treated weeks life. At present, family history only way identify patients are asymptomatic most being diagnosed after onset symptoms. We hypothesized staging system based on clinical indicators neurophysiological neuroimaging measures can predict posttreatment...
Two proteins having nominal molecular weights of 35,000 and 10,000 daltons are found in pulmonary surfactant. Although experiments on their immunological properties suggest that they share antigenic determinants, metabolic relationship is unknown. To study this question we injected [14C]palmitic acid or L-[3H]leucine into the femoral vein 59 puppies. We killed animals 30 min to 68 h after injection purified surface-active material from endobronchial lavage fluid. isolated apoprotein,...
Oncogenic mutations of FLT3 and KIT receptors are associated with poor survival in patients acute myeloid leukemia (AML) myeloproliferative neoplasms (MPNs), currently available drugs largely ineffective. Although Stat5 has been implicated regulating several lymphoid malignancies, how precisely regulates leukemogenesis, including its nuclear translocation to induce gene transcription, is poorly understood. In leukemic cells, we show constitutive activation focal adhesion kinase (FAK) whose...
We studied the metabolic turnover of major apoproteins pulmonary surfactant from rat lung and compared it with similar studies on metabolism dipalmitoyl phosphatidylcholine (DPPC). At varying times after injection tritiated leucine or palmitate we isolated alveolar cells fluid measured incorporation radioactive into 35,000-dalton (apoprotein A) 10,000-dalton B) DPPC. Maximum labeling apoprotein A in type II occurred within 1 h precursor declined next 19 h. The intracellular DPPC followed...
An acquired somatic mutation at codon 816 in the KIT receptor tyrosine kinase is associated with poor prognosis patients systemic mastocytosis and acute myeloid leukemia (AML). Treatment of leukemic cells bearing this an allosteric inhibitor p21-activated (Pak) or its genetic inactivation results growth repression due to enhanced apoptosis. Inhibition upstream effector Rac abrogates oncogene-induced activity Pak. Although both Rac1 Rac2 are constitutively activated via guanine nucleotide...
Methylosinus trichosporium OB3b synthesizes a soluble cytoplasmic methane monooxygenase when grown in copper-depleted medium and membrane-bound particulate under copper-replete conditions. The genes encoding the hydroxylase component of monooxygenase, carried on plasmid Escherichia coli, were insertionally inactivated using kanamycin cassette transferred back into M. by conjugation. Marker-exchange mutagenesis, via double homologous recombination event, yielded monooxygenase-negative mutant...
// Reuben Kapur 1, 2 , Jianjian Shi 1 Joydeep Ghosh Veerendra Munugalavadla 3 Emily Sims Holly Martin Lei Wei Raghuveer Singh Mali Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School Medicine, Indianapolis, IN, USA Microbiology and Immunology, Gilead Sciences, Inc., Foster City, CA, Correspondence to: Mali, e-mail: rsmali@iupui.edu Keywords: mast cells, Rho kinase, LIM cell growth, anaphylaxis Received: October 21, 2015 Accepted: January 29, 2016...
We examined the phylogeography of Least Brook Lamprey (Lampetra aepyptera) to recognize phylogenetically distinct clades within this species and estimate relative contributions vicariance dispersal distribution genetic variation. A combined data set from mitochondrial ND3 control region sequences identified 23 unique haplotypes among 21 populations. Eleven highly differentiated L. aepyptera were detected. Their distributions correspond different drainages and/or locations drainage. Clades...
Enteric fever (formerly typhoid fever) is a bacterial illness caused by fecal-oral transmission of Salmonella typhi or paratyphi. In early 2018, an outbreak resistant to third-generation cephalosporins, ampicillin, ciprofloxacin, trimethroprim-sulfamethoxazole, and chloramphenicol was reported in Pakistan. This strain, termed “extensively typhi,” has infected more than 5000 patients endemic areas South Asia, as well travelers from these areas, including 5 cases the United States. We present...
Real-world data are limited for patients with brain metastases secondary to metastatic breast cancer (MBC) and treated cyclin-dependent kinase 4/6 inhibitors (CDK4/6i). This study describes real-world outcomes in hormone receptor-positive, human epidermal growth factor 2-negative (HR+/HER2-) MBC diagnosis before abemaciclib initiation.