A5065737997- Cancer Mechanisms and Therapy
- Estrogen and related hormone effects
- Peptidase Inhibition and Analysis
- Phagocytosis and Immune Regulation
- Galectins and Cancer Biology
- PI3K/AKT/mTOR signaling in cancer
- Advanced Breast Cancer Therapies
- Gut microbiota and health
- Cancer Cells and Metastasis
- FOXO transcription factor regulation
- Cancer Treatment and Pharmacology
- Mechanisms of cancer metastasis
- Glutathione Transferases and Polymorphisms
- Diet and metabolism studies
- Synthesis and biological activity
- Nutritional Studies and Diet
- Bioinformatics and Genomic Networks
- Salivary Gland Disorders and Functions
- Global Maritime and Colonial Histories
- Cytokine Signaling Pathways and Interactions
- Gene expression and cancer classification
- Health and Medical Research Impacts
- Genomics and Phylogenetic Studies
- Global trade and economics
- Liver Disease Diagnosis and Treatment
Western University
2016-2018
Hospital for Sick Children
2011-2015
University Health Network
2011
University of Toronto
2011
University of California, Los Angeles
2011
Abstract PIK3CA, which codes for the p110α catalytic subunit of phosphatidylinositol 3-kinase, is one most frequently mutated genes in human breast cancer. Here, we describe a mouse model PIK3CA-induced cancer by using ROSA26 (R26) knock-in system, targeted Pik3ca alleles can be activated through transgenic expression Cre recombinase. We mated Pik3caH1047R and Pik3cawt lines with MMTV-Cre transgenics, express mammary epithelium. Starting at approximately 5 months age, female...
The UniFrac distance metric is often used to separate groups in microbiome analysis, but requires a constant sequencing depth work properly. Here we demonstrate that unweighted highly sensitive rarefaction instance and uniform data sets with no clear structure or separation between groups. We show this arises because of subcompositional effects. introduce information ratio UniFrac, two new weightings are not as allow greater outliers than classic weighted UniFrac. With expansion the toolbox,...
Abstract Breast cancer is associated with alterations in a number of growth factor and hormone-regulated signaling pathways. Mouse models metastatic breast typically feature mutated oncoproteins that activate PI3K, Stat3, Ras signaling, but the individual combined roles these pathways progression are poorly understood. In this study, we examined relationship between oncogenic pathway activation subtype by analyzing mouse mammary tumor formation which each was activated singly or pairwise....
This work was conducted to characterize the 16S rRNA gene profile of a cohort patients with traditional risk factors for developing atherosclerosis. The in were divided into two extremes; those predicted develop extreme atherosclerosis who did not (Protected), and (Unexplained). Bacterial DNA isolated from stool saliva this used determine V4 variable region sequence composition samples triplicate.
<p>Supplementary Figures 1-5. Supplementary Fig. 1. Kaplan-Meier overall survival curves and cause of death data for control experimental female mice. 2. Mammary pathology analysis estrogen receptor α staining 3. Activation Stat3 Mapk signaling in mouse mammary tumors. 4. Ras pathway activation is associated with relapse breast cancer patients independent PI3K activation. 5. Basal-like cancer.</p>
<p>Supplementary Figure Legends 1-5</p>
<div>Abstract<p>Breast cancer is associated with alterations in a number of growth factor and hormone-regulated signaling pathways. Mouse models metastatic breast typically feature mutated oncoproteins that activate PI3K, Stat3, Ras signaling, but the individual combined roles these pathways progression are poorly understood. In this study, we examined relationship between oncogenic pathway activation subtype by analyzing mouse mammary tumor formation which each was activated...
<div>Abstract<p>Breast cancer is associated with alterations in a number of growth factor and hormone-regulated signaling pathways. Mouse models metastatic breast typically feature mutated oncoproteins that activate PI3K, Stat3, Ras signaling, but the individual combined roles these pathways progression are poorly understood. In this study, we examined relationship between oncogenic pathway activation subtype by analyzing mouse mammary tumor formation which each was activated...
Supplementary Figure 3 from Cooperation between <i>Pik3ca</i> and p53 Mutations in Mouse Mammary Tumor Formation
Supplementary Figure 9 from Cooperation between <i>Pik3ca</i> and p53 Mutations in Mouse Mammary Tumor Formation
Supplementary Figure Legends from Cooperation between <i>Pik3ca</i> and p53 Mutations in Mouse Mammary Tumor Formation
Supplementary Figure 2 from Cooperation between <i>Pik3ca</i> and p53 Mutations in Mouse Mammary Tumor Formation
Supplementary Figure 7 from Cooperation between <i>Pik3ca</i> and p53 Mutations in Mouse Mammary Tumor Formation
Supplementary Figure 4 from Cooperation between <i>Pik3ca</i> and p53 Mutations in Mouse Mammary Tumor Formation
Supplementary Figure 8 from Cooperation between <i>Pik3ca</i> and p53 Mutations in Mouse Mammary Tumor Formation
Supplementary Figure 5 from Cooperation between <i>Pik3ca</i> and p53 Mutations in Mouse Mammary Tumor Formation
Supplementary Figure 6 from Cooperation between <i>Pik3ca</i> and p53 Mutations in Mouse Mammary Tumor Formation
Supplementary Figure 1 from Cooperation between <i>Pik3ca</i> and p53 Mutations in Mouse Mammary Tumor Formation
<p>Supplementary Figures 1-5. Supplementary Fig. 1. Kaplan-Meier overall survival curves and cause of death data for control experimental female mice. 2. Mammary pathology analysis estrogen receptor α staining 3. Activation Stat3 Mapk signaling in mouse mammary tumors. 4. Ras pathway activation is associated with relapse breast cancer patients independent PI3K activation. 5. Basal-like cancer.</p>