A5022104264- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Macrophage Migration Inhibitory Factor
- Transplantation: Methods and Outcomes
- RNA modifications and cancer
Zhengzhou University
2020-2023
Henan Provincial People's Hospital
2020-2023
Henan University
2021
CircPVT1 is demonstrated to promote cancer progression in esophageal squamous cell carcinoma (ESCC). However, the role and potential functional mechanisms of circPVT1 regulating 5-fluorouracil (5-FU) chemosensitivity remain largely unknown.ESCC cells resistant 5-FU were induced with continuous increasing concentrations step-wisely. A counting kit-8 assay was used analyze viability ESCC cells. LDH release kit evaluate cytotoxicity. RT-qPCR assess expression level non-coding RNAs cDNAs....
In recent years, increasing evidence indicates the significant roles of circRNAs in carcinogenesis. However, their lung cancer remain largely unclear. We profiled circRNA expression 10 paired non-small cell (NSCLC) and adjacent non-cancer tissues using high-throughput sequencing. A total 183 up-regulated 428 down-regulated were identified NSCLC (fold change ≥ 2, P < 0.05). Circ_0089823, an (5.4-fold, = 0.0017), was further investigated through loss-of-function gain-of-function. The...
The present study aims to elucidate the possible involvement of H19 in primary graft dysfunction (PGD) following lung transplantation (LT) and underlying mechanism. transcriptome data were obtained through high-throughput sequencing analysis, differential long noncoding RNAs messenger screened for coexpression analysis. interaction among H19, KLF5 CCL28 was analyzed. A hypoxia-induced human pulmonary microvascular endothelial cell injury model established, which knocked down its effect on...
Objective To explore the molecular mechanism by which long non-coding RNA (lncRNA) migration inhibitory factor antisense RNA1 (MIF-AS1)/microRNA (miRNAM miR)-370-3p/mitogen activated protein kinase 9 (MAP3K9) axis regulates proliferation, invasion and of non-small cell lung cancer (NSCLC). Methods Twenty samples NSCLC patients were collected from Henan Provincial People’s Hospital May 2017 to January 2019. There 12 males 8 females, aged (52.37±10.34) years. Real-time quantitative...