A5055207195- Analytical chemistry methods development
- Analytical Chemistry and Chromatography
- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Adsorption and biosorption for pollutant removal
- HER2/EGFR in Cancer Research
- Hydrogels: synthesis, properties, applications
- Quinazolinone synthesis and applications
- Synthesis and Biological Evaluation
- Advanced Drug Delivery Systems
- Mass Spectrometry Techniques and Applications
- Asymmetric Hydrogenation and Catalysis
- Extraction and Separation Processes
- Nanomaterials for catalytic reactions
- Dyeing and Modifying Textile Fibers
- Advanced Chemical Sensor Technologies
- Forensic Toxicology and Drug Analysis
- Ammonia Synthesis and Nitrogen Reduction
- Lung Cancer Treatments and Mutations
- Click Chemistry and Applications
- Radioactive element chemistry and processing
- Cancer therapeutics and mechanisms
- Carbon and Quantum Dots Applications
- Supramolecular Self-Assembly in Materials
- Crystallization and Solubility Studies
Taibah University
2023-2025
Newcastle University
2021-2022
New phenyldiazene scaffold-linked heterocyclic pyrazole, pyrimidinone, pyrimidinthione, and/or triazine rings have been developed and synthesized. Cytotoxicity of our derivatives was estimated on four cancer VERO normal cell lines targeting EGFRT790M (epidermal growth factor receptor) VEGFR-2 (vascular endothelial receptor-2) enzymes. Our new selectively inhibited both EGFR as they the essential structural requirements for inhibitors receptors. Derivative 14 most active A549, HCT116, HepG2,...
This study explores the pharmacological potential of chalcones through a multidisciplinary approach, including synthesis, quantum theory, molecular electrostatics, and density functional theory (DFT) calculations. The synthesized compound, analyzed via single crystal X-ray diffraction, crystallized in triclinic system (space group P-1) with C–H⋯O interactions stabilizing its structure. Hirshfeld surface analysis confirms these interactions, H–H contacts dominating (45.1 %). Molecular...
Fifteen new iodoquinazoline derivatives, 5a,b to 18, are reported in this study and their anticancer evaluation as dual inhibitors of EGFR WT T790M .
Phosphine oxide-decorated polymer immobilized ionic liquid stabilized RuNPs catalyse the hydrogenation of aryl ketones with remarkable selectivity for CO bond, complete to cyclohexylalcohol and levulinic acid γ-valerolactone.
Abstract Platinum nanoparticles stabilized by imidazolium‐based phosphine‐decorated Polymer Immobilized Ionic Liquids (PPh 2 ‐PIIL) catalyze the hydrolytic evolution of hydrogen from sodium borohydride with remarkable efficiency, under mild conditions. The composition polymer influences efficiency catalyst based on a polyethylene glycol modified imidazolium monomer (PtNP@PPh ‐PEGPIILS) more active than its N‐alkylated counterpart ‐ N ‐decylPIILS). maximum initial TOF 169 moleH .molcat −1...
Overall, drug design is a dynamic and evolving field, with researchers constantly working to improve their understanding of molecular interactions, develop new computational methods, explore innovative techniques for creating effective safe medications. The process can involve steps such as the identification targets, discovery lead compounds, optimization, preliminary testing, human trials, regulatory approval finally post-marketing surveillance, all aimed at bringing from concept market....