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Veda Bojar

ORCID: 0009-0009-0321-143X
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About
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A5081332547
Research Areas
  • Bacterial Genetics and Biotechnology
  • Protist diversity and phylogeny
  • Genomics and Phylogenetic Studies
  • Protein Structure and Dynamics
  • Bacteriophages and microbial interactions

Lund University
 2023

 The structural basis of hyperpromiscuity in a core combinatorial network of type II toxin–antitoxin and related phage defense systems
OPENALEX - Publications 
Karin Ernits Chayan Kumar Saha Tetiana Brodiazhenko Bhanupratap Singh Chouhan Aditi Shenoy and 17 more Jessica A. Buttress Julián J. Duque-Pedraza Veda Bojar Jose A. Nakamoto Tatsuaki Kurata Artyom A. Egorov Lena Shyrokova Marcus Johansson Toomas Mets Aytan Rustamova Jelisaveta Džigurski Tanel Tenson Abel Garcia‐Pino Henrik Strahl Arne Elofsson Vasili Hauryliuk Gemma C. Atkinson

Toxin-antitoxin (TA) systems are a large group of small genetic modules found in prokaryotes and their mobile elements. Type II TAs encoded as bicistronic (two-gene) operons that encode two proteins: toxin neutralizing antitoxin. Using our tool NetFlax (standing for Network-FlaGs toxins antitoxins), we have performed large-scale bioinformatic analysis proteinaceous TAs, revealing interconnected clusters constituting core network TA-like gene pairs. To understand the structural basis...

10.1073/pnas.2305393120 article EN cc-by Proceedings of the National Academy of Sciences 2023-08-09
 The structural basis of hyperpromiscuity in a core combinatorial network of Type II toxin-antitoxin and related phage defence systems
OPENALEX - Publications 
Karin Ernits Chayan Kumar Saha Tetiana Brodiazhenko Bhanupratap Singh Chouhan Aditi Shenoy and 15 more Julian J Duque-Pedraza Veda Bojar Jose A. Nakamoto Tatsuaki Kurata Artyom A. Egorov Lena Shyrokova Marcus Johansson Toomas Mets Aytan Rustamova Jelisaveta Džigurski Tanel Tenson Abel Garcia‐Pino Arne Elofsson Vasili Hauryliuk Gemma C. Atkinson

Toxin-antitoxin (TA) systems are a large group of small genetic modules found in prokaryotes and their mobile elements. Type II TAs encoded as bicistronic (two-gene) operons that encode two proteins: toxin neutralising antitoxin. Using our tool NetFlax (standing for Network-FlaGs toxins antitoxins) we have performed large-scale bioinformatic analysis proteinaceous TAs, revealing interconnected clusters constituting core network TA-like gene pairs. To understand the structural basis...

10.1101/2023.03.22.533649 preprint EN cc-by bioRxiv (Cold Spring Harbor Laboratory) 2023-03-22
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