A5025689455- Luminescence and Fluorescent Materials
- Innovative Microfluidic and Catalytic Techniques Innovation
- Methane Hydrates and Related Phenomena
- Diabetes Management and Research
- Hepatitis C virus research
- Nanoplatforms for cancer theranostics
- CO2 Sequestration and Geologic Interactions
- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Supramolecular Chemistry and Complexes
- Boron Compounds in Chemistry
- Hepatitis B Virus Studies
- Photoreceptor and optogenetics research
- Advanced Photocatalysis Techniques
- Carbon Dioxide Capture Technologies
- Covalent Organic Framework Applications
- Advancements in Transdermal Drug Delivery
- Liver Disease Diagnosis and Treatment
Nanjing University of Science and Technology
2024-2025
Four 2,9-aryl substituted 6,13-bis(triisopropylsilylethynyl)pentacene derivatives were synthesized as sonosensitizers. Their extensive delocalized π-electron conjugation system facilitated the generation of reactive oxygen species (ROS) under ultrasound irradiation. Therapeutic results validate that as-prepared compounds have significant advantages in sonodynamic therapy.
Recent insights into covalent organic frameworks (COFs) provide an opportunity for developing new sonosensitizers with the advantages of both small molecules and inorganic nanoagents. Herein, we synthesize two benzotrithiophene-based imine-linked COFs (BTT-DPh-COF BTT-DPy-COF) through density-functional-theory-guided structure editing. The tailored donor-acceptor (D-A) structures optimize band position endow them good intrinsic sonodynamic activity, which can efficiently kill cancer cells,...
Despite the therapeutic benefits of insulin-pramlintide dual-hormone therapy in diabetes, its application potential has been limited due to a lack efficient delivery routes. Here, we developed temperature-responsive foam nanoengine (HormFoam) and combined it with customized spraying device further construct an situ foam-generating system for improving rectal bioavailability therapy. To support rapid clinical translation, continuous microfluidic preparation HormFoam was proposed, including...