A5092560353- Carbon dioxide utilization in catalysis
- Enzyme Catalysis and Immobilization
- Analytical Chemistry and Chromatography
- Free Radicals and Antioxidants
- Chemical synthesis and alkaloids
- Chemistry and Chemical Engineering
- Synthesis of Indole Derivatives
University of Milan
2023-2025
Natural hydroxycinnamic acid amides (HCAAs) and riparins offer significant health benefits. However, their extraction from natural sources is difficult, traditional synthetic methods remain wasteful, raising the need for more efficient alternatives. In this work, a two-step chemo-enzymatic flow method esterification amidation of phenolic acids was developed successfully applied to synthesis riparin derivatives HCAAs. The Fischer optimized using vanillic as model starting material SiliaBond...
A series of carbonate and carbamate derivatives natural phenols, tyrosol hydroxytyrosol, were synthetized through a chemo-enzymatic flow approach. First, the chemoselective synthesis hydroxytyrosol carbonates was performed using immobilized lipase B from Candida antarctica as catalyst in tert-amyl alcohol, non-conventional green solvent. Then, two selected reacted with appropriate amine to obtain desired carbamates. All compounds isolated moderate good yields. The showed increased...
A facile and convenient lipase-catalyzed flow approach for the chemoselective synthesis of tyrosol hydroxytyrosol methyl carbonates has been developed. Then, value-added symmetrical were prepared.