A5076545274- Iron Metabolism and Disorders
- Trace Elements in Health
- Erythrocyte Function and Pathophysiology
- Neuroscience and Neuropharmacology Research
- Occupational and environmental lung diseases
- Ion channel regulation and function
- Microtubule and mitosis dynamics
- Organic Electronics and Photovoltaics
- Eosinophilic Disorders and Syndromes
- Semiconductor materials and devices
- Occupational exposure and asthma
- Cellular Mechanics and Interactions
- Folate and B Vitamins Research
- Semiconductor materials and interfaces
- Mast cells and histamine
University of Bologna
2025
AREA Science Park
2024
Elettra-Sincrotrone Trieste S.C.p.A.
2024
University of Trieste
2023-2024
Asbestos fibers interact with many different proteins and may affect either their structure or functions. The aim of this study was to determine whether ferritin absorbed onto might modify its ferroxidase activity. By measuring apo-ferritin activity, data demonstrated that in the presence did not significantly enzymatic However, absence promoted ferrous iron oxidation. Evidence suggests asbestos promote oxidation subsequently cellular homeostatic mechanisms.
Background: The interaction of asbestos fibers with target cell membranes is still poorly investigated. Here, we detected and characterized an enhancement chloride conductance in Xenopus oocyte induced by exposure to crocidolite (Croc) fibers. Methods: A two-microelectrode voltage clamp technique was used test the effect Croc fiber suspensions on outward currents evoked step membrane depolarization. Calcium imaging experiments were also performed investigate variation ‘resting’ [Ca2+]i...
One of the main problems related to ferruginous-asbestos bodies (ABs) exposure is their potential pathogenetic role in asbestos-related diseases. The aim this study was examine whether purified ABs, might stimulate inflammatory cells. ABs were isolated by exploiting magnetic properties, therefore avoiding strong chemical treatment usually employed for purpose. This latter treatment, which based upon digestion organic matter with concentrated hypochlorite, may markedly modify AB structure and...
Many years ago, asbestos fibers were banned and replaced by synthetic vitreous because of their carcinogenicity. However, the toxicity latter is still under debate, especially when it concerns early fiber interactions with biological cell membranes. Here, we aimed to investigate effects a named FAV173 on Xenopus laevis oocyte membrane, model have already used characterize effect crocidolite exposure. Using an electrophysiological approach, found that, similarly asbestos, was able stimulate...