A5054021532- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular and exercise physiology
- Physical Activity and Health
- Heart Rate Variability and Autonomic Control
- Peripheral Artery Disease Management
- Optical Imaging and Spectroscopy Techniques
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Liver Diseases and Immunity
- Cardiovascular Disease and Adiposity
- Sleep and related disorders
- Nutritional Studies and Diet
- Menopause: Health Impacts and Treatments
- Cardiac Imaging and Diagnostics
- Sports Performance and Training
- Tea Polyphenols and Effects
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Blood Pressure and Hypertension Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Pediatric Hepatobiliary Diseases and Treatments
- Cardiovascular Issues in Pregnancy
- Stroke Rehabilitation and Recovery
- Sleep and Wakefulness Research
- Traumatic Brain Injury Research
Royal Liverpool University Hospital
2024
University of Liverpool
2024
Liverpool John Moores University
2016-2021
Radboud University Nijmegen
2017-2019
Radboud University Medical Center
2017-2019
York St John University
2019
Unilever (Netherlands)
2016
Gloucestershire Hospitals NHS Foundation Trust
2015
Gloucestershire Royal Hospital
2015
Texas A&M University – Commerce
2001
Endothelial dysfunction is involved in the development of atherosclerosis, which precedes asymptomatic structural vascular alterations as well clinical manifestations cardiovascular disease (CVD). function can be assessed non-invasively using flow-mediated dilation (FMD) technique. Flow-mediated represents an endothelium-dependent, largely nitric oxide (NO)-mediated dilatation conduit arteries response to imposed increase blood flow and shear stress. affected by (CV) risk factors, relates...
ObjectiveTreatment of juxtarenal and complex neck abdominal aortic aneurysms (AAAs) is now commonly by endovascular rather than open surgical repair (OSR). Published comparisons show poor validity scientific precision. UK-COMPASS a comparative cohort study treatments vs. OSR for patients with an AAA unsuitable standard on label aneurysm (EVAR).MethodsAll procedures in England (November 2017 to October 2019) were identified, anatomy assessed Corelab, peri-operative risk scores determined,...
Decreased cerebrovascular blood flow and function are associated with lower cognitive functioning increased risk of neurodegenerative diseases. Prolonged sitting impairs peripheral function, but its effects on the cerebrovasculature unknown. This study explored effect uninterrupted breaking up time healthy desk workers. Fifteen participants (10 male, 35.8 ± 10.2 yr, body mass index: 25.5 3.2 kg/m 2 ) completed, separate days, three 4-h conditions in a randomized order: 1) (SIT), 2) 2-min...
Endothelial function, assessed using brachial artery flow-mediated dilation (FMD), predicts future cardiovascular disease (CVD) risk. This study established age- and sex-specific reference intervals for FMD in healthy individuals examined the relation with CVD risk factors. In a retrospective design, we pooled (acquired according to expert-consensus guidelines protocol analysis) participant characteristics/medical history from 5362 (4–84 years; 2076 females). Healthy (n=1403 [582 females])...
Breaking up prolonged sitting with physical activity (PA) breaks prevents conduit artery dysfunction. However, the optimal break strategy to achieve this, in terms of frequency or duration PA, is not known. This study assessed effect breaking different PA strategies on lower limb peripheral endothelial function. Fifteen participants (10 male, 35.8 ± 10.2 years, BMI: 25.5 3.2 kg m-2 ) completed, separate days, three 4-h conditions a randomized order: (1) uninterrupted (SIT), (2) 2-min...
Background Premenopausal women have a lower incidence of cardiovascular disease, which may partly be due to protective effect estrogen on endothelial function. Animal studies suggest that also improve the relationship between shear rate ( SR ) and We aimed explore function (ie, flow‐mediated dilation [ FMD ]) area under curve SRAUC in versus men, pre‐ postmenopausal women. Methods Results Brachial artery were measured accordance with expert‐consensus guidelines 932 healthy participants who...
Increase in mean shear stress represents an important and potent hemodynamic stimulus to improve conduit artery endothelial function humans. No previous study has examined whether fluctuations rate patterns, without altering stress, impacts function. This the hypothesis that 30-min exposure presence of unaltered rate, improves brachial flow-mediated dilation. Fifteen healthy men (27.3 ± 5.0 yr) completed study. Bilateral dilation was assessed before after unilateral 30 min intermittent...
Menopause is associated with lower peripheral vascular function; however, cerebrovascular responses to this time-period are unclear. We aimed describe and differences between pre- postmenopausal women.Fifty women (N = 100) underwent assessments of cerebral blood flow; reactivity autoregulation; carotid artery reactivity; brachial femoral flow-mediated dilation; carotid, brachial, intima-media thickness. Comparisons were made followed by a secondary analysis 20) late premenopausal those...
Abstract The aim of this pilot study is to obtain estimates for the change in maternal cerebrovascular (primary) and offspring vascular structure (secondary) during healthy pregnancy that includes structured exercise. Eighteen pregnant women self-assigned a moderate-intensity aerobic exercise intervention or control group. Maternal cerebral blood flow (CBF) at middle artery, cerebro- peripheral-vascular function was assessed end each trimester. Offspring carotid artery intima-media thickness...
Prolonged sitting has a detrimental effect on peripheral conduit artery endothelial function, whilst breaking up prolonged time can prevent such impairments. The of and cerebral blood flow (CBF) is currently unknown. Importantly, decreased CBF related to lower cognitive functioning increased risk impairment dementia. PURPOSE:To determine the uninterrupted with light intensity walking in healthy subjects. METHODS: Thirteen participants (8 male, 37.3±10.1 years old, BMI: 25.6±3.4 kg/m2)...
Supplying the brain with enough blood flow is essential to keep us alive and maintain our health. Reductions in can negatively affect ability think. Decreased also lead diseases, such as dementia, which a condition that causes permanent memory loss confusion. Scientists are beginning think sitting may be bad for flow. Understanding how affects therefore very important. We conducted study participants either sat down without any breaks 4 h, or but took short walking break every 30 min, longer...
Purpose The aim of this study was to examine if catechin-rich green tea abrogates the negative effects 7-days physical inactivity and excessive calorie-intake on insulin homeostasis peripheral vascular function. Methods Using a randomized, double-blind, crossover design, twelve healthy men (29 ± 6 yrs) underwent unhealthy lifestyle (UL), including (−50% steps/day) overfeeding (+50% kcal/day). This combined with consumption (UL-tea; 3 doses/day) or placebo (UL-placebo). Before after each...
The purpose of this study was to compare intraindividual differences over time on self-monitored HR (SHR) and Ratings Perceived Exertion (RPE). subjects were 19 volunteer college-aged students (M = 20 ± 7 y; range 18–26 y.) enrolled in an aerobic dance class. sample included 17 females 2 males. HRs monitored by Polar monitors (PHR) served as the criterion. Data collected at two week intervals throughout study. A repeated measures ANOVA used make comparisons coefficients variations computed...