A5108222122- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Colorectal and Anal Carcinomas
- Metastasis and carcinoma case studies
- Esophageal Cancer Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Lymphoma Diagnosis and Treatment
- Esophageal and GI Pathology
- Neuroendocrine Tumor Research Advances
- Lung Cancer Treatments and Mutations
- Celiac Disease Research and Management
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Alcohol Consumption and Health Effects
- Viral-associated cancers and disorders
- Eosinophilic Esophagitis
- Colorectal Cancer Surgical Treatments
- HER2/EGFR in Cancer Research
- Liver Disease Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- TGF-β signaling in diseases
- Cancer Research and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Screening and Detection
- Helicobacter pylori-related gastroenterology studies
Kyushu University
2025
Suwa Red Cross Hospital
2005
National Cancer Center Hospital East
1996-1999
Nippon Medical School
1998
National Cancer Center
1993-1997
For one-piece resection the conventional technique of endoscopic mucosal (EMR) is limited to gastric tumors 10 mm or less in size. In this retrospective study, we investigated efficacy and complications associated with a new EMR method, using an insulated-tip diathermic knife (IT-EMR).In total 41 patients were resected IT-EMR.One-piece rates 82% (14/17) for lesions less, 75% (12/16) those between 11 20 mm, 14% (1/7) over mm. Complication severe bleeding perforation 22% 5%, respectively. With...
Peritoneal dissemination is one of the most common complications malignancies digestive system, such as gastric or pancreatic cancers. Yet, no effective therapy has been established so far to alleviate this devastating and often fatal end-stage condition. Here we describe a novel approach intraperitoneal (i.p.) lipofection suicidal gene cancer cells in mouse peritoneal model. A human cell line, PSN-1, was inoculated into cavity nude mice. Eight days later, herpes simplex virus thymidine...
BACKGROUND The authors previously found specific mutations of the K-ras gene at codon 12 in pancreatic juice 67% patients (6 9) with ductal carcinoma, and detection these was useful for diagnosis. This study performed to detect evaluate from intraductal papillary mucinous tumor pancreas, which is considered a low grade malignancy. results were interpreted viewpoint clinical significance. METHODS examined using seminested polymerase chain reaction analysis combined restriction enzyme...
A pilot study was undertaken to clarify the efficacy of concurrent chemoradiotherapy against locally advanced esophageal carcinoma. The 20 patients in this had previously untreated carcinoma with evidence T4 disease and/or distant node metastases. Chemotherapy consisted protracted infusion 5-fluorouracil at a dose 400 mg/m2/day on days 1-5 and 8-12, combined 2-h cisplatinum 40 mg/m2 1 8. Radiation treatment for mediastinum administered 5 per week 3 wk 2 Gy/day, along chemotherapy. These...
Immunohistochemical analysis was performed to determine the clinical role of p53 mutations in patients with locally advanced esophageal carcinomas treated concurrent chemoradiotherapy. The subjects this study were 20 previously untreated evidence T4 disease and/or distant node metastases. Treatment comprised protracted 5-fluorouracil and 2-h cisplatinum infusions along radiation treatment a total dose 60 Gy. Tumor specimens from 18 analyzed immunohistochemically. Mutant protein expression...
The endoscopic appearances of the gastrointestinal lymphomas differ widely, and it is often difficult to make distinction between a benign lymphoproliferative disorder malignant lymphoma even with histologic evaluation. Since almost all primary tract are B‐cell origin, confirmation monoclonality in immunoglobulin (Ig) helpful for differential diagnosis. Rearrangements Ig heavy chain gene were examined by polymerase reaction (PCR) analysis frozen biopsy specimens human stomach. sensitivity...
We macroscopically classified 25 gastric and 23 colorectal advanced cancers into "contracted" "uncontracted" types, found immunohistochemically that integrin subunit alpha 3 was more frequently expressed in the extracellular matrix (ECM) former than latter (75%:9/12 vs. 38%: 5/13 86%:6/7 25%:4/16 cancers, respectively). Integrin also producing transforming growth factor-beta (TGF-beta), which is related to ECM deposition, expression cell mobility, those did not produce TGF-beta (67%:10/15...
An early phase II study was conducted to evaluate the anti-tumor effects and toxicity of etoposide in patients with unresectable or relapsed advanced gastric cancer. From April 1991 December 1992, 13 were enrolled into this study; one subsequently considered ineligible. Before enrollment, all had been treated chemotherapy which did not include etoposide. Etoposide (100 mg/m2/day) administered as an intravenous infusion over 120 min for five consecutive days repeated every four weeks. Seven...
Abstract: Accurately diagnosing the depth of invasion in small early gastric cancers is essential for determining whether endoscopic resection a lesion indicated. It often difficult, however, to demonstrate such lesions by conventional ultrasonography (EUS) which considered be useful tool assessing invasion. To facilitate demonstration EUS, we injected 2‐5 ml saline into submucosal layer at an appropriate point 1 ‐2 cm from lesion. With collection serving as guide, was demonstrable on same...
症例は62歳，女性。平成7年9月頃よりめまい，脱力感，粘液性下痢が出現したため近医を受診した。脱水症と診断され，点滴治療を受けたが軽快せず，また大腸内視鏡検査で直腸に腫瘤が発見されたため，精査加療目的で当院に紹介された。当院受診時，下痢に伴う脱水および著明な血清電解質異常（Na 137mEq/l，K 2.2mEq/l，Cl 82mEq/l）が認められた。内視鏡検査で直腸に巨大な絨毛腫瘍が認められ，また生検組織診で中等度異型を伴う絨毛腺腫と診断されたため，肛門括約筋を温存した外科的切除が施行された。腫瘍は大きさが17×9.5cmで，表面は絨毛状を呈し，組織学的には粘膜内に限局した高分化型腺癌であった。術後，血清電解質は正常化した。本邦における電解質異常をきたした大腸絨毛腫瘍の報告はこれまでに25例にすぎず，まれな症例と考えられたため報告した。