A5101904235- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- RNA Interference and Gene Delivery
- Chronic Lymphocytic Leukemia Research
- Cardiac Valve Diseases and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Aortic Disease and Treatment Approaches
- Chronic Myeloid Leukemia Treatments
- Head and Neck Cancer Studies
- Hematological disorders and diagnostics
- Inflammatory Bowel Disease
- Cardiac Structural Anomalies and Repair
- Nanoplatforms for cancer theranostics
- Tracheal and airway disorders
- Oral and Maxillofacial Pathology
- Nutrition and Health in Aging
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Viral-associated cancers and disorders
- Neutropenia and Cancer Infections
- Phase Change Materials Research
- Eosinophilic Disorders and Syndromes
Yokohama City University
2016-2025
Yokohama City University Medical Center
2021-2025
Kansai Rosai Hospital
2023-2025
Kanagawa Industrial Technology Center
2020-2024
Kanagawa Cancer Center
2023-2024
Kanagawa Prefectural Hospital Organization
2023-2024
The University of Tokyo
2018-2023
Nagasaki University
1995-2023
Tokyo Institute of Technology
2020-2022
Tokyo Medical and Dental University
2020-2022
(1-->3)-beta-D-Glucan is one of the major structural components fungi, and it seems that can be detected by fractionated (1-->3)-beta-D-glucan-sensitive component from a Limulus lysate, factor G. We evaluated concentration (1-->3)-beta-D-glucan using G other fungal antigens in 24 patients with clinical evidence mycosis 36 healthy subjects. The mean plasma subjects was found to 2.7 +/- 1.9 pg/ml (range, < 6.9 pg/ml), substantially higher all 11 candidemia (mean, 2,207.4 pg/ml; range, 325.4...
The CC chemokine receptor 7 (CCR7) balances immunity and tolerance by homeostatic trafficking of immune cells. In cancer, CCR7-mediated leads to lymph node metastasis, suggesting the as a promising therapeutic target. Here, we present crystal structure human CCR7 fused protein Sialidase NanA using data up 2.1 Å resolution. shows ligand Cmp2105 bound an intracellular allosteric binding pocket. A sulfonamide group, characteristic for various ligands, binds patch conserved residues in Gi region...
Treatment of immunologically cold tumors is a major challenge for immune checkpoint inhibitors (ICIs). Interleukin 12 (IL-12) can invigorate ICIs against by establishing robust antitumor immunity. However, its toxicity and systemic induction counteracting immunosuppressive signals have hindered translation. Here, IL-12 activity spatiotemporally controlled safely boosting efficacy without the stimulation interfering responses generating nanocytokine that remains inactive at physiological pH,...
Insulin delivery in a self-regulated and painless way to tightly control the glycemic level is highly demanded for diabetes treatment. Phenylboronic acid (PBA) has gained great research interests due its synthetic nature reversible binding capability with glucose. A totally smart PBA hydrogel exhibiting efficient glucose sensitivity at physiological pH temperature been previously developed. However, clinical applications may be hampered by temperature-dependent release profile. Herein, we...
Abstract Rheumatoid arthritis (RA) is associated with an increased risk of developing lymphoma. Although the pathogenesis still unclear, appears to be related high inflammatory activity RA, immunosuppressive agents, or Epstein‐Barr virus (EBV) infection. We investigated relationship between EBV latent infection and methotrexate (MTX)‐associated lymphoma in RA patients. Nine patients were diagnosed non‐Hodgkin's (NHL) during MTX treatment for a multicenter study. The pathologic findings...
Heme oxygenase (HO)-1 has anti-oxidative, anti-inflammatory, and anti-apoptotic activities. However, little is known about the regulation of HO-1 in human primary acute myeloid leukemia (AML) cells. Here we investigated expression established AML cells as well other types leukemic normal monocytes, its regulatory mechanism by transcriptional repressor, BTB CNC homology 1 (Bach1), activator, nuclear factor erythroid-derived 2 related (Nrf2). Leukemic cell lines such U937 expressed HO-1,...
Abstract Messenger RNA (mRNA) shows high therapeutic potential, though effective delivery systems are still needed for boosting its application. Nanocarriers loading mRNA via polyion complexation with block catiomers into core‐shell micellar structures promising enhancing delivery. Engineering the interaction between and through polymer design can promote development of mRNA‐loaded micelles (mRNA/m) increased efficiency. Particularly, polycation chain rigidity may critically affect...
Abstract Xkr8–Basigin is a plasma membrane phospholipid scramblase activated by kinases or caspases. We combined cryo-EM and X-ray crystallography to investigate its structure at an overall resolution of 3.8 Å. Its membrane-spanning region carrying 22 charged amino acids adopts cuboid-like stabilized salt bridges between hydrophilic residues in transmembrane helices. Phosphatidylcholine binding was observed hydrophobic cleft on the surface exposed outer leaflet membrane. Six placed from top...
Recently, phenylboronic acid (PBA) gel containing microneedle (MN) technology with acute and sustained glucose-sensitive functionality has attracted significant research attention. Herein, we report a polyvinyl alcohol(PVA)-coated MNs patch an interconnected porous drug reservoir for enhanced skin penetration efficiency mechanical strength. The hybrid fabricated novel, efficient method displayed "cake-like" two-layer structure, the tip part being composed of boronate-containing smart...
Messenger RNA (mRNA) therapeutics have recently demonstrated high clinical potential with the accelerated approval of SARS-CoV-2 vaccines. To fulfill promise unprecedented mRNA-based treatments, development safe and efficient carriers is still necessary to achieve effective delivery mRNA. Herein, we prepared mRNA-loaded nanocarriers for enhanced in vivo using biocompatible block copolymers having functional amino acid moieties tunable interaction The were based on flexible poly(ethylene...
Objective High-dose methotrexate (HD-MTX) is widely used as central nervous system (CNS) prophylaxis in patients with diffuse large B-cell lymphoma (DLBCL) who are at a high risk of CNS relapse. Ensuring safe prophylactic administration minimal adverse events key concern; however, few studies have detailed the safety profile HD-MTX high-risk DLBCL. We analyzed associated this population, focusing on delayed MTX elimination. Methods This multicenter retrospective study included 98 DLBCL...
The purpose of this study was to evaluate the survival impact and prognostic factors pulmonary metastasectomy in patients with metastasis from head neck cancer.A retrospective 69 analyzed. Twenty-four (35%) underwent metastasectomy, remaining 45 (65%) were treated chemotherapy or best supportive care.The 1-year overall (OS) 28%. Pulmonary (p = .01) histology < .001) had a significant on prognosis. One-year OS who those did not 90% 35%, respectively. In group, recurrence primary ahead lung...