A5101565986- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Pancreatic function and diabetes
- Lipid Membrane Structure and Behavior
- Dermatology and Skin Diseases
- Cancer, Hypoxia, and Metabolism
- Ocular Surface and Contact Lens
- RNA Interference and Gene Delivery
- Curcumin's Biomedical Applications
- Hippo pathway signaling and YAP/TAZ
- Diabetes Management and Research
- MicroRNA in disease regulation
- Electrochemical sensors and biosensors
- Skin Protection and Aging
- Cancer-related molecular mechanisms research
- Hydrogen's biological and therapeutic effects
- Advanced biosensing and bioanalysis techniques
- Synthesis and Biological Activity
- Anesthesia and Neurotoxicity Research
- Plant Ecology and Soil Science
- Pharmacological Effects of Natural Compounds
- Spinal Cord Injury Research
- PI3K/AKT/mTOR signaling in cancer
- Municipal Solid Waste Management
- Immunotherapy and Immune Responses
Nanjing Tech University
2021-2024
University of California, Santa Barbara
2024
Nanjing University
2024
Shanghai University of Electric Power
2024
Henan University of Technology
2024
Mongolian National University
2023
Guangdong Medical College
2020-2023
Wenzhou Medical University
2019-2023
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2023
Orthopaedic Center
2023
Abstract Achieving persistent glycemic control in a painless and convenient way is the ultimate goal of diabetes management. Herein, an “enzyme‐free” polymeric microneedle (MN)‐array patch composed boronate‐containing hydrogel semi‐interpenetrated by biocompatible silk fibroin developed. Consistent with previous reports, presence boronate‐hydrogel allows for glucose‐responsive diffusion‐control insulin, while crystalline component serves as matrix‐stiffener to validate skin penetration....
Microneedle (MN) technology, which can transdermally deliver insulin in a noninvasive manner, offers promising way to replace subcutaneous self-injection for diabetes management. Hydrogel is an attractive candidate MN fabrication because of its biocompatibility, controllable degradability, and possibility achieve sustained as well stimuli-responsive drug delivery. Herein, we report smart composed semi-interpenetrating network (semi-IPN) hydrogel prepared by biocompatible silk fibroin (SF)...
Although topical application of minoxidil is a widely used, FDA-approved therapy for androgenetic alopecia (AGA) treatment, it suffers from low bioavailability, the requirement frequent long-term use, and side effects. With similar structure as minoxidil, kopexil kopyrrol are less toxic have been commercialized, but show an inferior hair regeneration effect compared to minoxidil. Herein, we developed hyaluronic acid (HA)-based dissolvable microneedles (MNs) delivery platform integrated with...
Insulin delivery in a self-regulated and painless way to tightly control the glycemic level is highly demanded for diabetes treatment. Phenylboronic acid (PBA) has gained great research interests due its synthetic nature reversible binding capability with glucose. A totally smart PBA hydrogel exhibiting efficient glucose sensitivity at physiological pH temperature been previously developed. However, clinical applications may be hampered by temperature-dependent release profile. Herein, we...
Objective: The objective of this work was to prepare coenzyme Q10 loaded nanostructured lipid carriers (Q10-NLC) and evaluate its epidermal targeting effect.Methods: Q10-NLC prepared by high-pressure microfluidics technique. Formulations preparation parameters were optimized with response surface design. characterized PCS, TEM, DSC PXRD. penetration from the formulations through skins into evaluated in vitro using Franz diffusion cells fitted SD rat skins. In release, long-term stability...
Recently, phenylboronic acid (PBA) gel containing microneedle (MN) technology with acute and sustained glucose-sensitive functionality has attracted significant research attention. Herein, we report a polyvinyl alcohol(PVA)-coated MNs patch an interconnected porous drug reservoir for enhanced skin penetration efficiency mechanical strength. The hybrid fabricated novel, efficient method displayed "cake-like" two-layer structure, the tip part being composed of boronate-containing smart...
A hydrophobic polyphenol compound extracted from turmeric, curcumin has been widely utilized as traditional medicines for centuries in China and India. Over the last decades, because of its low toxicity, extensive studies have focused on physicochemical properties pharmacological activities various diseases, such cancer, cardio-vascular disease, inflammatory bowel, wound healing, Alzheimer's rheumatoid arthritis, diabetes. In particular, bioactivities an effective chemopreventive agent,...
Breast cancer (BRCA) is the most common in women, while bones are one of sites metastasis. Although new diagnostic methods or radiation chemotherapies and targeted therapies have made huge advances, occurrence bone metastasis also linked with poorer survival. Enhancer RNAs (eRNAs) been demonstrated to participate progression tumorigenesis However, role eRNAs BRCA remains largely unclear.Gene expression profiling 1,211 primary 17 metastases samples were retrieved from The Cancer Genome Atlas...
Low intracellular delivery efficiency and multidrug resistance are among major barriers to effective cancer therapy.
Microplastic pollution is a research hotspot around the world. This study investigated characteristics of microplastic in freshwater environments 21 major cities across China. Through indoor and outdoor experimental analysis, we have identified spatial temporal distribution China’s environments. Our findings indicate that average concentration microplastics 3502.6 n/m3. The majority these are fibrous (42.5%), predominantly smaller than 3 mm (28.1%), mostly colored (64.7%). primary chemical...
Phenylboronic acid (PBA) is a widely exploited glucose-sensitive element for constructing glucose-responsive hydrogels to enable smart insulin delivery.
Sensitive skin is defined as with low tolerance and high reactivity. Natural products, such paeoniflorin madecassoside, have unique care functionality. However, because they are hampered by the barrier, madecassoside difficulty penetrating stratum corneum, resulting in weakened barrier repair anti-inflammatory effects. In addition, there a lack of detailed studies on efficacy paeonol madecassic human skin, especially 3D models clinical trials. To overcome transdermal delivery issue, we...
A hydrophobic polyphenol compound extracted from turmeric, curcumin has been widely utilized as traditional medicines for centuries in China and India. Over the last decades, because of its low toxicity, extensive studies have focused on physicochemical properties pharmacological activities various diseases, such cancer, cardio-vascular disease, inflammatory bowel, wound healing, Alzheimer’s rheumatoid arthritis, diabetes. In particular, bioactivities an effective chemopreventive agent,...
Transdermal insulin delivery in a painless, convenient, and on-demand way remains long-standing challenge. A variety of smart microneedles (MNs) fabricated by glucose-responsive phenylboronic acid hydrogels have been previously developed to provide painless autonomous release response glucose level change. However, like the majority MNs, their transdermal efficiency was still relatively low compared that with subcutaneous injection. Herein, we report an iontophoresis (ITP)-integrated MNs...
Accumulating evidence demonstrates that not only sustained elevation of blood glucose levels but also the fluctuation represents key determinants for diabetic complications and mortality. Current closed-loop insulin therapy option is limited to use electronics-based systems, although it poses some technical issues with high cost. Here we demonstrate an electronics-free, synthetic boronate gel-based insulin-diffusion-control device technology can cope fluctuations potentially address...
Abstract Diabetes is one of the most devastating global diseases with an ever-increasing number patients. Achieving persistent glycemic control in a painless and convenient way unmet goal for diabetes management. Insulin therapy commonly utilized treatment usually relies on patient self-injection. This not only impairs patient’s quality life fails to precisely blood glucose level but also brings risk life-threatening hypoglycemia. “closed-loop” insulin delivery systems could avoid these...
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Biological tissues transform between solid- and liquidlike states in many fundamental physiological events. Recent experimental observations further suggest that two-dimensional epithelial these solid-liquid transformations can happen via intermediate akin to the hexatic phases observed equilibrium melting. The phase is characterized by quasi-long-range (power-law) orientational order but no translational order, thus endowing some structure an otherwise structureless fluid. While it has been...
Electric power transmission lines are integral components of the system, and their digitalization intelligent construction important directions for promoting transformation development energy power. This paper presents a three-dimensional digital management platform tower based on We3D software, which can comprehensively display model surrounding geographical information. By integrating with data interfaces, it enables simple rapid access to information sensor data. facilitates comprehensive...
Hair is a stable specimen and has longer detection window (from weeks to months) than blood urine. Through the analysis of hair, long-term information drug use identified person could be explored. Our work establish an ultra-performance liquid chromatography–tandem mass spectroscopy (UPLC–MS/MS) method for simultaneous determination methamphetamine, amphetamine, morphine, monoacetylmorphine, ketamine, norketamine, 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyamphetamine (MDA)...
In article number 1807369, Akira Matsumoto and co-workers report an electronics-free, enzyme-free, nanoparticle-free smart artificial on-skin pancreas, which is a hybrid microneedle-array patch fabricated with glucose-sensitive boronate-hydrogel biocompatible silk fibroin semi-interpenetrating network. This microneedles-array could mimic the functionality of pancreas provide on-demand insulin delivery in safe, painless, convenient way.