A5022569261- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Oral and gingival health research
- Hip disorders and treatments
- Pelvic and Acetabular Injuries
- Spine and Intervertebral Disc Pathology
- Particle Accelerators and Free-Electron Lasers
- Cerebral Palsy and Movement Disorders
- Surgical site infection prevention
- Hedgehog Signaling Pathway Studies
- Pharmacological Effects and Toxicity Studies
- Particle accelerators and beam dynamics
- Peptidase Inhibition and Analysis
- Bone Tissue Engineering Materials
- Connective tissue disorders research
- Cardiac, Anesthesia and Surgical Outcomes
- Bone Metabolism and Diseases
- Astrophysics and Star Formation Studies
- Congenital Diaphragmatic Hernia Studies
- Galaxies: Formation, Evolution, Phenomena
- Gyrotron and Vacuum Electronics Research
- Liver Disease Diagnosis and Treatment
- Stellar, planetary, and galactic studies
- Photocathodes and Microchannel Plates
- Astronomy and Astrophysical Research
Harvard University
2023-2025
Nihon University
2013-2024
Boston Children's Hospital
2022-2024
Nagoya University Hospital
2024
Columbia University
2013-2023
Morgan Stanley Children's Hospital
2010-2023
Boston Children's Museum
2023
Columbia University Irving Medical Center
2013-2022
Tokyo Medical and Dental University
2010-2022
Kanagawa Industrial Technology Center
2022
Abstract We have used homologous recombination in embryonic stem cells to generate mice with a targeted disruption of the osteopontin (Opn, or Spp1, for secreted phosphoprotein 1) gene. Mice homozygous this fail express (OPN) as assessed at both mRNA and protein level, although an N-terminal fragment OPN is detectable extremely low levels bones −/− animals. The Opn−/− are fertile, their litter size normal, they develop normally. teeth animals not expressing morphologically normal level light...
Protein-free: A hydrogel containing phenylboronate was optimized so as to undergo rapid glucose-dependent changes in the state of hydration under physiological aqueous conditions. localized dehydration gel surface form a "skin layer" enabled control release insulin from gel. This is induced by fluctuations glucose concentration range between normo- and hyperglycemia.
Background: Early-onset scoliosis is a heterogeneous condition, with highly variable manifestations and natural history. No standardized classification system exists to describe group patients, guide optimal care, or prognosticate outcomes within this population. A for early-onset thus necessary prerequisite the timely evolution of care these patients. Methods: Fifteen experienced surgeons participated in nominal technique designed achieve consensus-based scoliosis. comprehensive list...
In Brief Study Design. This was a retrospective cohort study using previously matched convenience sample of 34 patients. Objective. sought to determine the relative corrective benefits these 2 types constructs in correction coronal and sagittal curves patients with adolescent idiopathic scoliosis (AIS). addition, were compared for balance. Summary Background Information. Recent clinical research suggests that thoracic pedicle screw (all-screw constructs) are more effective than hybrid lumbar...
Perioperative surgical site infection (SSI) after pediatric spine fusion is a recognized complication with rates between 0.5% and 1.6% in adolescent idiopathic scoliosis up to 22% "high risk" patients. Significant variation the approach prophylaxis has been well documented. The purpose of this initiative develop consensus-based "Best Practice" Guideline (BPG), informed by both available evidence literature expert opinion, for high-risk patients undergoing fusion. For effort, high risk was...
In Brief Study Design. Retrospective cohort study. Objective. The purpose of this study is to evaluate pulmonary function and quality life (QOL) in children treated with early spinal fusion for progressive congenital scoliosis. Summary Background Data. relationships between radiographic measures, tests (PFT), QOL were examined. Methods. Twenty-one patients scoliosis evaluated using radiographs, PFT, the Child Health Questionnaire (CHQ) at 12.6 ± 3.5 years. They 6.9 2.3 years postdefinitive...
Background: Surgical site infection following correction of pediatric scoliosis is well described. However, we are aware no recent multicenter study describing the rates surgical infection, and associated pathogens, among patients with different etiologies for scoliosis. Methods: A multicenter, retrospective review infections undergoing spinal instrumentation to correct was performed at three children’s hospitals in United States. Study subjects included all posterior from January 2006...
Although previous studies have attempted to create "electronics-free" insulin delivery systems using glucose oxidase and sugar-binding lectins as a glucose-sensing mechanism, no successful clinical translation has hitherto been made. These protein-based materials are intolerant of long-term use storage because their denaturing and/or cytotoxic properties. We provide solution by designing protein-free totally synthetic material-based approach. Capitalizing on the sugar-responsive properties...
Abstract Achieving persistent glycemic control in a painless and convenient way is the ultimate goal of diabetes management. Herein, an “enzyme‐free” polymeric microneedle (MN)‐array patch composed boronate‐containing hydrogel semi‐interpenetrated by biocompatible silk fibroin developed. Consistent with previous reports, presence boronate‐hydrogel allows for glucose‐responsive diffusion‐control insulin, while crystalline component serves as matrix‐stiffener to validate skin penetration....
Microneedle (MN) technology, which can transdermally deliver insulin in a noninvasive manner, offers promising way to replace subcutaneous self-injection for diabetes management. Hydrogel is an attractive candidate MN fabrication because of its biocompatibility, controllable degradability, and possibility achieve sustained as well stimuli-responsive drug delivery. Herein, we report smart composed semi-interpenetrating network (semi-IPN) hydrogel prepared by biocompatible silk fibroin (SF)...
The goal of early-onset scoliosis (EOS) treatment is to improve health-related quality life (HRQoL) for patients and reduce the burden on their parents or caregivers. purpose this study develop finalize 24-item Early-Onset Scoliosis Questionnaire (EOSQ-24), examine validity, reliability, responsiveness EOSQ-24 in measuring patients' HRQoL, caregivers, caregiver's finances. also established aged-matched normative values EOSQ-24.The was administered caregivers male female aged 0 18 years with...
Background: Spinal cord monitoring is now considered standard care during surgery for spinal deformity. Combined somatosensory and motor evoked potential allows the detection of early dysfunction in most patients. The purpose current study was to identify clinical factors that increase risk intraoperative electrophysical changes provide management recommendations. Methods: records 162 consecutive patients who underwent treatment deformity at a tertiary referral center were reviewed....
Background Treatment of children with early onset scoliosis (EOS) seeks to improve natural history and health related quality life (QOL). QOL measurement presents a significant challenge given the young age, comorbidities, heterogeneity this population. The purpose study is develop disease specific measure reflecting issues importance EOS patients caretakers that responsive clinical treatment changes. Methods Review literature relevant measures informed development semistructured qualitative...
Insulin delivery in a self-regulated and painless way to tightly control the glycemic level is highly demanded for diabetes treatment. Phenylboronic acid (PBA) has gained great research interests due its synthetic nature reversible binding capability with glucose. A totally smart PBA hydrogel exhibiting efficient glucose sensitivity at physiological pH temperature been previously developed. However, clinical applications may be hampered by temperature-dependent release profile. Herein, we...
A hydroxyapatite/type I collagen (HAp/Col) composite, in which the hydroxyapatite nanocrystals align along molecules, has been prepared. The biocompatibility, osteoconductive activity, and efficacy as a carrier of recombinant human bone morphogenetic proteins (rhBMPs) this novel biomaterial were examined. composite material was implanted backs Wistar rats, specimens collected for histological observations until week 24. In second experiment, other samples (5 × 5 10 mm3) drilled immersed...
Purpose: The purpose of this study is to report the current incidence rates pediatric spinal cord injury (SCI) in United States and identify specific high-risk populations as a knowledge basis for improving prevention treatment traumatic injury. Methods: Kids' Inpatient Database (KID) National Trauma Data Bank (NTDB) were used investigate etiology SCI. Results: Significant differences annual rate SCI found exist between patient stratified by race sex. African Americans (1.53 cases/100,000...
Background: The traditional techniques to treat thoracic insufficiency syndrome (TIS) are not able stabilize or improve chest wall size pulmonary function while allowing spine growth. To this end, vertical expandable prosthetic titanium rib (VEPTR) was specifically designed TIS by growth of the cavity and control/correction deformity. purpose study determine quality life (QOL) children with its impact on their parents before after implantation VEPTR also compare these results those healthy...
In contrast with treatment recommendations for adolescent idiopathic scoliosis, there are no clear algorithms treating patients early-onset scoliosis. There has been rapid expansion of options children including casting, growth rods, the vertical expandable prosthetic titanium rib, and anterior vertebral stapling.Given range options, we assessed variability in decision making regarding scoliosis.We presented 12 clinical radiographic vignettes about scoliosis to 13 experienced spine surgeons...
Little is known regarding the psychological dysfunction in children who require repetitive surgery for early onset scoliosis (EOS). This study was conducted to examine neurobehavioral functioning of with EOS at various stages treatment rib-based growing rod system (RBGRS). We hypothesized that these would demonstrate evidence dysfunction.Twelve patients were included analyses. At time evaluation, baseline clinical, and demographic information number RBGRS-related surgeries obtained. All...