A5109922082- Attention Deficit Hyperactivity Disorder
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Autism Spectrum Disorder Research
- Obsessive-Compulsive Spectrum Disorders
- Carbohydrate Chemistry and Synthesis
- Bioactive Compounds and Antitumor Agents
- Synthesis and Biological Activity
- Gambling Behavior and Treatments
- Child and Adolescent Psychosocial and Emotional Development
- Microbial Natural Products and Biosynthesis
- Eating Disorders and Behaviors
- Genetics and Neurodevelopmental Disorders
- Personality Disorders and Psychopathology
- Pharmacogenetics and Drug Metabolism
- Peroxisome Proliferator-Activated Receptors
- Substance Abuse Treatment and Outcomes
- Memory and Neural Mechanisms
- Cancer, Hypoxia, and Metabolism
- Sexual Differentiation and Disorders
- Cannabis and Cannabinoid Research
- Genomic variations and chromosomal abnormalities
- Sexuality, Behavior, and Technology
- RNA and protein synthesis mechanisms
- Cancer-related gene regulation
Wuhan University
2024-2025
Zhongnan Hospital of Wuhan University
2024
Bristol-Myers Squibb (Switzerland)
2013
City Of Hope National Medical Center
1996-2003
Prior studies have reported an association between the presence of 7 repeat allele 48 bp polymorphism third cytoplasmic loop dopamine D4 receptor gene (DRD4) and novelty seeking behaviors, attention deficit hyperactivity disorder (ADHD), Tourette syndrome (TS), pathological gambling, substance abuse. However, other failed to replicate some these observations. To determine whether we could associations genotyped 737 individuals from four different groups control subjects, 707 index subjects...
Polymorphisms of three different dopaminergic genes, dopamine D2 receptor (DRD2), beta-hydroxylase (D beta H), and transporter (DAT1), were examined in Tourette syndrome (TS) probands, their relatives, controls. Each gene individually showed a significant correlation with various behavioral variables these subjects. The additive substractive effects the genes by genotyping all same set For 9 20 TS associated comorbid behaviors there was linear association between degree loading for markers...
As access to gambling increases there is a corresponding increase in the frequency of addiction gambling, known as pathological gambling. Studies have shown that number different neurotransmitters are affected gamblers and genetic factors play role. Polymorphisms at 31 genes involved dopamine, serotonin, norepinephrine, GABA were genotyped 139 age, race, sex‐matched controls. Multivariate regression analysis was used with presence or absence dependent variable, coded independent variables....
The present study is based on the proposal that complex disorders resulting from effects of multiple genes are best investigated by simultaneously examining candidate in same group subjects. We have examined effect 20 for dopamine, serotonin, and noradrenergic metabolism a quantitative score attention deficit hyperactivity disorder (ADHD) 336 unrelated Caucasian genotypes each gene were assigned 0 to 2, results literature or studies an independent set subjects (literature‐based scoring),...
In a previous study (Comings DE et al. Comparison of the role dopamine, serotonin, and noradrenergic genes in ADHD, ODD conduct disorder. Multivariate regression analysis 20 genes. Clin Genet 2000: 57: 178–196) we examined serotonin norepinephrine attention deficit hyperactivity disorder (ADHD), oppositional defiant (ODD), (CD), using multivariate associations (MAA) technique. We have now brought total number to 42 by adding an additional 22 candidate These results indicate that even with...
Cloninger (Cloninger CR. Neurogenetic adaptive mechanisms in alcoholism. Science 1987: 236: 410–416) proposed three basic personality dimensions for temperament: novelty seeking, harm avoidance, and reward dependence. He suggested that seeking primarily utilized dopamine pathways, avoidance serotonin dependence norepinephrine pathways. Subsequently, one additional temperament dimension (persistence) character (cooperativeness, self‐directedness, self‐transcendence) were added to form the...
THE male predominance of externalizing behaviors suggests that the X-linked androgen gene might be involved. Since shorter alleles CAG and GGC polymorphisms AR are associated with increased expression we sought to determine whether they were also behaviors. We examined 302 subjects consisting Tourette syndrome probands controls. ANOVA showed a significant association between haplotypes ADHD (p < 0.0001), conduct disorder (CD; p 0.017), oppositional defiant (ODD; 0.004) lowest scores in those...
Aminoglycosides (AGs) are a class of antibiotics with broad spectrum activity. However, their use is limited by safety concerns associated nephrotoxicity and ototoxicity, as well drug resistance. To address these issues, semi-synthetic approaches for modifying natural AGs have generated new generations AGs, however, types modification due to significant challenges in synthesis. This study explores novel approach that harness the bacterial biosynthetic machinery gentamicins kanamycins create...
Non-ribosomal peptide synthetases (NRPSs) are key enzymes in pharmaceutical synthesis, with condensation (C) domains catalyzing amide bond formation between aminoacyl substrates. However, recent research has elucidated that the catalytic capabilities of C extend beyond traditional bonds. In this study, we elucidate cyclization mechanism NRPS-derived natural products hangtaimycin (HTM), characterized by a 2,5-diketopiperazine (DKP) moiety which involves an intramolecular vinylamide-mediated...
Abstract Non‐ribosomal peptide synthetases (NRPSs) are key enzymes in pharmaceutical synthesis, with condensation (C) domains catalyzing amide bond formation between aminoacyl substrates. However, recent research has elucidated that the catalytic capabilities of C extend beyond traditional bonds. In this study, we elucidate cyclization mechanism NRPS‐derived natural products hangtaimycin (HTM), characterized by a 2,5‐diketopiperazine (DKP) moiety which involves an intramolecular...
Defects in serotonin metabolism, and abnormalities both blood tryptophan levels, have been reported many psychiatric disorders. Tryptophan 2,3-dioxygenase (TDO2) is the rate limiting enzyme for breakdown of to JV-formyl kenurenine. Functional variants this gene could account observed simultaneous increases or decreases various We identified four different polymorphisms human TDO2 gene. Association studies show a significant association one more these Tourette syndrome (TS), attention deficit...
The activity of human phenylethanolamine N-methyltransferase (PNMT) is reduced in the neurons those cells many subcortical areas brain that are known to undergo neurodegeneration Alzheimer disease (AD). Others have reported PNMT decreased brains persons with AD and decrease enzymatic due a amount enzyme protein. We previously described two polymorphisms, G-353A G-148A, promoter region gene coding for PNMT. These markers were tested their association occurrence sporadic AD. Genotyping 131...
We observed a significant increase in the number subjects carrying NAT1*10 allele of N-acetyl transferase1 (NAT1) gene controls with MAST-R score ≥ 4 and drug and/or alcohol dependence (p = 0.003), compared <4. These results suggest that alterations acetylation one or more CNS compounds may be related to both mild severe substance abuse.
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that plays a key role in regulating glucose homeostasis via its activity at the GLP-1 receptor (GLP-1R). To date, GLP-1R has become attractive therapeutic target for type 2 diabetes (T2D). Several agonists have been developed or are clinical trials such as: Exenatide, Liraglutide, Lixisentide, Dulagutide, Semiglutide, Efpeglenatide, and Albenatide. These drugs stimulate G-protein-coupled receptors (GPCR) resulting adenylated cyclase...
Abstract The incidence rates of diabetes and cancer are growing globally. It is reported that type 2 (T2D) associated with increased risk cancers, which suggests a synergy. There strong association among inflammation on diabetes, reflected by the high cytokine prevalence in microenvironment. Previously our studies showed IL-2 IFN-γ were downregulated but IL-6 TNFα upregulated diabetic mice. levels IL-2, IFN-γ, returned to baseline similar non-diabetic mice after treatment CJC-1134-PC. In...