A5033500590- Neonatal and fetal brain pathology
- Infant Development and Preterm Care
- Opioid Use Disorder Treatment
- Neonatal Respiratory Health Research
- Substance Abuse Treatment and Outcomes
- HIV, Drug Use, Sexual Risk
- Prenatal Substance Exposure Effects
- Functional Brain Connectivity Studies
- Heart Rate Variability and Autonomic Control
- Primary Care and Health Outcomes
- Genomics and Rare Diseases
- EEG and Brain-Computer Interfaces
- HIV/AIDS Research and Interventions
- Immune Cell Function and Interaction
- Neuroscience of respiration and sleep
- HIV Research and Treatment
- Neonatal Health and Biochemistry
- Infant Nutrition and Health
- Forensic Toxicology and Drug Analysis
- Healthcare Policy and Management
- Mental Health Treatment and Access
- Genomic variations and chromosomal abnormalities
- Cardiac electrophysiology and arrhythmias
- Congenital Diaphragmatic Hernia Studies
- Gender, Labor, and Family Dynamics
Fairfax Neonatal Associates
2013-2025
Portland State University
2016-2024
Oregon Health & Science University
2016-2024
Inova Children's Hospital
2011-2024
University of Portland
2022-2024
Defence Science and Technology Group
2024
Dartmouth College
2024
John Marshall Law School
2020
Kaiser Permanente San Francisco Medical Center
2019
Inova Health System
2015-2016
Abstract Germline mutations are the source of evolution and contribute substantially to many health-related processes. Here we use whole-genome deep sequencing data from 693 parents–offspring trios examine de novo point (DNMs) in offspring. Our estimate for mutation rate per base pair generation is 1.05 × 10 −8 , well within range previous studies. We show that maternal age has a small but significant correlation with total number DNMs offspring after controlling paternal (0.51 additional...
Overdoses continue to increase in the US, but contribution of methamphetamine use is understudied rural communities.
Abstract Background In recent years, stimulant use has increased among persons who opioids in the rural U.S., leading to high rates of overdose and death. We sought understand motivations contexts for a large, geographically diverse sample drugs (PWUD) settings. Methods conducted semi-structured individual interviews with PWUD at 8 U.S. sites spanning 10 states 65 counties. Content areas included general substance use, injection drug changes harm reduction practices. used an iterative...
In a previous study (Comings DE et al. Comparison of the role dopamine, serotonin, and noradrenergic genes in ADHD, ODD conduct disorder. Multivariate regression analysis 20 genes. Clin Genet 2000: 57: 178–196) we examined serotonin norepinephrine attention deficit hyperactivity disorder (ADHD), oppositional defiant (ODD), (CD), using multivariate associations (MAA) technique. We have now brought total number to 42 by adding an additional 22 candidate These results indicate that even with...
The development of antigen-specific functional T lymphocyte immunity in infants and children is an area immunology that needs elucidation. Leukocytes from cord blood (CBL) PBL different ages who were the hospital for minor surgical procedures compared with healthy adults their ability to generate helper cell (Th) responses assessed by vitro proliferation IL-2 production after stimulation with: influenza A virus (FLU); tetanus toxoid (TET); adult allogeneic either undepleted (ALLO) or...
Preterm birth (PTB) complications are the leading cause of long-term morbidity and mortality in children. By using whole blood samples, we integrated whole-genome sequencing (WGS), RNA (RNA-seq), DNA methylation data for 270 PTB 521 control families. We analyzed this combined dataset to identify genomic variants associated with secondary analyses very early (VEPTB) as well other subcategories disease that may contribute PTB. identified differentially expressed genes (DEGs) methylated loci...
Abstract Background Drug overdose deaths in the United States exceeded 100,000 2021 and 2022. Substance use stigma is a major barrier to treatment harm reduction utilization priority target ending epidemic. However, little known about relationship between overdose, especially rural areas. We aimed characterize association felt non-fatal multi-state sample of rural-dwelling people who drugs. Methods Between January 2018 March 2020, 2,608 reporting past 30-day opioid were recruited via...
The nucleoside analog 3'-azido-3'-deoxythymidine (ZDV) has widespread clinical use but also is carcinogenic in newborn mice exposed to the drug utero and becomes incorporated into mouse DNA. This pilot study was designed determine ZDV incorporation human blood cell DNA from adults infants.In this prospective cohort study, peripheral mononuclear cells (PBMC) were obtained 28 non-pregnant 12 pregnant women given therapy, six with no exposure ZDV, who last received > or = 6 months previously....
Objectives: The objective of this study was to investigate methamphetamine use among people who opioids in rural Oregon communities explore reasons for and perceptions consequences. Methods: We conducted interviews surveys with participants inject drugs or misuse prescription 2 counties high opioid overdose rates. Survey were identified through participant-driven sampling initiated syringe service programs field outreach (n = 144). Semi-structured recruited from the same locations 52)....
Monocyte-derived cytokine production by cord blood mononuclear cells (CBMC) from infants born to human immunodeficiency virus (HIV)-positive and -negative women was measured determine whether monocyte dysfunction could contribute the accelerated HIV disease of pediatric patients. Production interleukin (IL)-12, but not that tumor necrosis factor-alpha IL-10, reduced, compared with adult peripheral (PBMC). This deficiency more pronounced in HIV-positive women, whose IL-12 also deficient. CBMC...
Background: There is a growing move to provide care for premature infants in single family, private room neonatal intensive unit (NICU) place of the traditional shared space, open bay NICU. The resultant effect on developing microbiota unknown. Study Design: Stool and groin skin swabs were collected from shared-space NICU (old NICU) single-family (new same hospital campus. Metagenomic sequencing was performed data analyzed by CosmosID bioinformatics software package. Results: no significant...
The meconium microbiome may provide insight into intrauterine and peripartum exposures the very earliest intestinal pioneering microbes. Prenatal antibiotics have been associated with later obesity in children, which is thought to be driven by dependent mechanisms. However, there little data regarding associations of prenatal or antibiotic exposure, without cesarean section (CS), features microbiome. In this study, 16S ribosomal RNA gene sequencing was performed on bacterial DNA samples from...
While the microbiome is increasingly seen as a targetable contributor to atopic dermatitis (AD), questions remain whether dysbiosis secondary diseased skin or if it predates symptom onset. Previous work has evaluated how changes with age and established influence of factors like delivery mode breastfeeding on global diversity. However, these studies were unable identify taxa which predict subsequent AD.Skin swab samples collected from first week life for 72 children in neonatal intensive...
Preterm (PT) birth is an established risk factor for high mortality and morbidity rates. Infants school-aged children have been well-studied, but few described neuropsychological behavioral outcomes at preschool age. We compared a 2004–2006 preterm/extremely low weight (ELBW) cohort (PT/ELBW; N = 60) born ≤33 weeks gestation <1,000 g with term-born participants (N 90) age 3. PT/ELBW subgroups (<26 weeks; 26–33 weeks) performed more poorly than the group on verbal, nonverbal, fine motor,...
Objective: Title 42 of the Code Federal Regulations Part 2 (42 CFR 2) controls release patient information about treatment for substance use disorders. In 2016, Substance Abuse and Mental Health Services Administration (SAMHSA) released a proposed rule to update regulations, reduce provider burdens, facilitate exchange. Oregon's Medicaid program (Oregon Plan) altered financing structure medical, dental, behavioral care promote greater integration coordination. A qualitative analysis examined...
The CTN-0067 CHOICES trial tests implementation of extended-release naltrexone (XR-NTX) versus treatment-as-usual (TAU) for opioid use disorders (OUD) in HIV clinics to improve viral suppression. study team investigated recruitment strategies elucidate the barriers and facilitators enrollment study.Methods: Semi-structured, in-depth, digitally recorded interviews were completed with recruitment-related staff medical providers (n = 26) from six participating fall 2018. Interviews probed 1)...
Illicit fentanyl has contributed to a drastic increase in overdose drug deaths. While subsumed the supply Northeastern and Midwestern USA, it more recently reached Western USA. For this study, we explored perspectives of people who use drugs (PWUD) on changing Oregon, experiences response fentanyl-involved overdose, recommendations from PWUD reduce risk within context illicit fentanyl's dramatic recreational over past decade.We conducted in-depth interviews by phone with 34 Oregon May June...
Abstract Background Drug overdose is the leading cause of death after release from prison, and this risk significantly higher among women compared to men. Within first 2 weeks release, drug 12.7 times than general population, with further elevated females. Although female inmates have rates opioid use disorder post-release fatality, justice-involved are under-represented in studies medications for disorder. The Reducing Overdose After Release Incarceration (ROAR) pilot intervention...