A5094154434- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Nanowire Synthesis and Applications
- T-cell and B-cell Immunology
Boston Children's Hospital
2024
Harvard University
2024
MICA and MICB are Class I MHC-related glycoproteins that upregulated on the surface of cells in response to stress, for instance due infection or malignant transformation. MICA/B ligands NKG2D, an activating receptor NK cells, CD8 + T γδ cells. Upon engagement with these cytotoxic eradicate MICA/B-positive targets. is frequently overexpressed cancer epithelial hematopoietic origin. Here, we created nanobodies recognize MICA. Nanobodies, VHHs, recombinantly expressed variable regions camelid...
Abstract The glycoproteins MICA and MICB are upregulated on the surface of cells undergoing stress, for instance due to (viral) infection or malignant transformation. MICA/B ligands activating receptor NKG2D, found cytotoxic immune like NK cells, CD8+ T γδ cells. Upon engagement these activated eradicate MICA/B-positive targets, assisted by secretion cytokines. Nanobodies, VHHs, derived from variable regions camelid heavy-chain only immunoglobulins. Nanobodies characterized their small size,...