A5085758769- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Properties of Aromatic Compounds
- Axial and Atropisomeric Chirality Synthesis
- Crystallography and molecular interactions
- Porphyrin and Phthalocyanine Chemistry
- Photochromic and Fluorescence Chemistry
- Advanced NMR Techniques and Applications
- Mass Spectrometry Techniques and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Graphene research and applications
- Analytical Chemistry and Chromatography
- DNA and Nucleic Acid Chemistry
- Molecular spectroscopy and chirality
University of Göttingen
2020-2023
Abstract The synthesis of unprecedented BINOL‐derived cationic phosphonites is described. Through the use these phosphanes as ancillary ligands in Au I catalysis, a highly regio‐ and enantioselective assembly appropriately designed alkynes into 1‐(aryl)benzo[5]carbohelicenes achieved. modular enhanced reactivity that they impart to ‐centers after coordination have been found be key features allow an optimization reaction conditions until desired benzo[5]helicenes are obtained with high yield...
A series of helically shaped benzo[b]chryseno[4,3-d]thiophenes, naphtho[1,2-b]phenanthro[4,3-d]thiophenes, and chryseno[3,4-b]naphtho[1,2-d]thiophenes is synthesized via a highly enantioselective Au-catalyzed intramolecular alkyne hydroarylation reaction. The inversion barriers the structures obtained are determined both theoretically experimentally, their chiroptical properties reported. Preliminary studies on post-synthetic functionalization these thiahelicenes transformation into...
Abstract A series of expanded helicenes different sizes and shapes incorporating phenyl‐ biphenyl‐substituents at the deepest part their fjord have been synthesized via sequential Au‐catalyzed hydroarylation appropriately designed diynes, racemization barriers calculated employing electronic structure methods. These show that overall profile inversions (energies, number transition states intermediates, relative position) is intensively affected by interplay steric attractive London...
Hydrogen/deuterium exchange mass spectrometry (HDX-MS) is a biophysical technique well suited to the characterization of protein dynamics and protein–ligand interactions. In order accurately define rate exchange, HDX experiments require repeated measure deuterium incorporation into target across range time points. Accordingly, HDX-MS experiment automation, number automated systems for have been developed. The most widely utilized platforms all operate an integrated design, where robotic...
Abstract The synthesis of unprecedented BINOL‐derived cationic phosphonites is described. Through the use these phosphanes as ancillary ligands in Au I catalysis, a highly regio‐ and enantioselective assembly appropriately designed alkynes into 1‐(aryl)benzo[5]carbohelicenes achieved. modular enhanced reactivity that they impart to ‐centers after coordination have been found be key features allow an optimization reaction conditions until desired benzo[5]helicenes are obtained with high yield...
Like the arms of a dancer, which are waved following rhythm music but avoid colliding with her head or body; flexible expanded helicenes find different pathways to reverse their position depending on size and nature insert placed in innermost zone fjord. This work presents synthesis series in-fjord substituted an estimation inversion barriers through state-of-the-art quantum calculations. Interestingly, energetic profile inversions is intensively affected by interplay steric attractive...