A5028912184- Proteoglycans and glycosaminoglycans research
- Analytical Chemistry and Chromatography
- Glycosylation and Glycoproteins Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Chemical Reactions and Isotopes
- Heparin-Induced Thrombocytopenia and Thrombosis
- Indoor Air Quality and Microbial Exposure
- Spectroscopy and Chemometric Analyses
- Pneumonia and Respiratory Infections
- Biosimilars and Bioanalytical Methods
- Advanced Chemical Sensor Technologies
- Inhalation and Respiratory Drug Delivery
- Antibiotics Pharmacokinetics and Efficacy
- Protein purification and stability
- Drug Solubulity and Delivery Systems
- Mass Spectrometry Techniques and Applications
- Fluorine in Organic Chemistry
- Analytical Methods in Pharmaceuticals
- Phytochemical Studies and Bioactivities
- Clinical Laboratory Practices and Quality Control
- Pharmaceutical Economics and Policy
- Olfactory and Sensory Function Studies
- Salivary Gland Disorders and Functions
- Infection Control and Ventilation
- Injection Molding Process and Properties
GlaxoSmithKline (United States)
2014-2017
GlaxoSmithKline (United Kingdom)
2017
United States Food and Drug Administration
1995-2012
GlaxoSmithKline (Netherlands)
2012
Center for Drug Evaluation and Research
2004-2011
There is an urgent need to determine whether oversulfated chondroitin sulfate (OSCS), a compound contaminating heparin supplies worldwide, the cause of severe anaphylactoid reactions that have occurred after intravenous administration in United States and Germany.Heparin procured from Food Drug Administration, consisting suspect lots associated with clinical events as well control heparin, were screened blinded fashion both for presence OSCS any biologic activity could potentially link...
Here we report results from the analyses by enzymatic digestion and reversed-phase ion-pairing liquid chromatography mass spectrometry (RPIP-LC-MS) of active pharmaceutical ingredient (API) unfractionated heparins (UFHs) six different manufacturers one USP standard sample. We employed a reverse phase method using C(18) column hexylamine as reagent with acetonitrile gradient elution to separate disaccharides generated lyase I III (E.C. 4.2.2.7 4.2.2.8) before introduction into an ion-trap...
To differentiate heparin samples with varying amounts of dermatan sulfate (DS) impurities and oversulfated chondroitin (OSCS) contaminants, proton NMR spectral data for sodium active pharmaceutical ingredient from different manufacturers were analyzed using multivariate chemometric techniques. A total 168 divided into three groups: (a) Heparin, [DS] ≤ 1.0% [OSCS] = 0%; (b) DS, > (c) OSCS, 0% any content DS. The models constructed validated two well-established methods: soft independent...
abstract Four brands (Copenhagen Snuff, Skoal Bandit Classic, Wintergreen Long Cut, and Fine Cut) of smokeless tobacco products were tested for their rate nicotine release into artificial saliva via direct contact or through a dialysis bag. Nicotine was determined by reversed-phase liquid chromatography. When samples in with saliva, most the released from first minute. marketed as sachet, slower sachet intact than without sachet. placed inside bag, much primarily depended upon permeability...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetic nitrogen isotope effects on methyl transfer to aminesJoseph L. Kurz, Michael W. Daniels, Karen S. Cook, and Moheb M. NasrCite this: J. Phys. Chem. 1986, 90, 21, 5357–5360Publication Date (Print):October 1, 1986Publication History Published online1 May 2002Published inissue 1 October 1986https://pubs.acs.org/doi/10.1021/j100412a092https://doi.org/10.1021/j100412a092research-articleACS PublicationsRequest reuse permissionsArticle...