A5020543321- Proteoglycans and glycosaminoglycans research
- Rice Cultivation and Yield Improvement
- Augmented Reality Applications
- Genetic Mapping and Diversity in Plants and Animals
- Systemic Lupus Erythematosus Research
- Industrial Vision Systems and Defect Detection
- Agriculture, Soil, Plant Science
- Robotics and Sensor-Based Localization
- Angiogenesis and VEGF in Cancer
- Remote Sensing and Land Use
- Cancer, Hypoxia, and Metabolism
- Bioenergy crop production and management
- Manufacturing Process and Optimization
- Heparin-Induced Thrombocytopenia and Thrombosis
- Robot Manipulation and Learning
- HER2/EGFR in Cancer Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Mast cells and histamine
- GABA and Rice Research
- BIM and Construction Integration
- Cancer Mechanisms and Therapy
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Plant Virus Research Studies
- Coal and Its By-products
Tsinghua University
2021-2024
Sichuan Academy of Agricultural Sciences
2004-2021
Momenta Pharmaceuticals (United States)
2008-2019
Center for Drug Evaluation and Research
2017
United States Food and Drug Administration
2017
Massachusetts Institute of Technology
2003-2004
University of Cambridge
2003
Whitehead Institute for Biomedical Research
2003
There is an urgent need to determine whether oversulfated chondroitin sulfate (OSCS), a compound contaminating heparin supplies worldwide, the cause of severe anaphylactoid reactions that have occurred after intravenous administration in United States and Germany.Heparin procured from Food Drug Administration, consisting suspect lots associated with clinical events as well control heparin, were screened blinded fashion both for presence OSCS any biologic activity could potentially link...
Heparan sulfate proteoglycans (HSPGs) play a key role in shaping the tumor microenvironment by presenting growth factors, cytokines, and other soluble factors that are critical for host cell recruitment activation, as well promoting progression, metastasis, survival. M402 is rationally engineered, non-cytotoxic heparan (HS) mimetic, designed to inhibit multiple implicated tumor-host interactions, including VEGF, FGF2, SDF-1α, P-selectin, heparanase. A single s.c. dose of effectively...
Heparin and low-molecular weight heparins (LMWHs), complex, sulfated polysaccharides isolated from endogenous sources, are potent modulators of hemostasis. LMWHs interact with multiple components the coagulation cascade to inhibit clotting process. Pharmaceutical preparations these complex polysaccharides, typically porcine intestinal mucosa, heterogeneous in length composition and, hence, highly polydisperse. Because structural heterogeneity heparin LMWHs, correlating their activity a...
Although heparin and low-molecular-weight heparins (LMWH) have been widely used clinically as anticoagulants, their broader use has limited by the lack of noninvasive delivery methods for this class molecules. In study, we demonstrate an efficient, rapid, reproducible system through lungs that is not confined to particles a certain geometric or aerodynamic diameter. Importantly, blood levels after intrapulmonary administration either LMWH were comparable s.c. but are characterized more rapid...
Abstract Background The goal of this study is to use comprehensive molecular profiling characterize clinical response anti-TNF therapy in a real-world setting and identify reproducible markers differentiating good responders non-responders rheumatoid arthritis (RA). Methods Whole-blood mRNA, plasma proteins, glycopeptides were measured two cohorts biologic-naïve RA patients ( n = 40 36) from the Corrona CERTAIN (Comparative Effectiveness Registry Therapies for Arthritis Inflammatory...
A series of size-defined low-molecular-weight heparins were generated by regioselective chemical modifications and profiled for their in vitro vivo activities. The compounds displayed reduced anti-coagulant activity, demonstrated varying affinities toward angiogenic growth factors (fibroblast factor-2, vascular endothelial factor stromal cell-derived factor-1α), inhibited the P-selectin/P-selectin glycoprotein ligand-1 interaction and, notably, exhibited anti-tumor efficacy a murine melanoma...
High amylopectin grains of waxy sorghum have a high economic value in the food and bioenergy industries because their increased starch digestibility higher ethanol conversion rate compared with wild-type grains. Mutation granule-bound synthase (GBSS) gene contributes to phenotype. Two classes alleles, wx b , been characterized previously. In present work, we identified two novel types mutations GBSS gene, designated as c d . The allele has G deletion at 5′ splicing site ninth intron, causing...
Augmented reality (AR) has been widely employed in assembly guidance and maintenance as an excellent visualization tool. On this basis, AR technology combined with visual inspection become a research topic to realize rapid intuitive quality while reducing operators' workload. This article proposes novel multitarget, AR-based, result method, which detected information is matched prior knowledge via high-precision registration. First, multimarker-based global registration method designed...
Hepatocyte growth factor/scatter factor (HGF/SF) can sufficiently and independently induce pathophysiological angiogenesis. However, the treatment strategies have mostly been unsuccessful. The present study is first to evaluate possible targeting of downstream signals for inhibition HGF/SF-induced angiogenesis.In a multichannel scratch assay with human endothelial cells (ECs), HGF/SF induced strong prolonged activation MAPK cell proliferation that was inhibited by PD98059...
Augmented assembly (AA) is being gradually incorporated into manual owing to its abundant instruction forms, high efficiency of information transmission, and robust interactivity. However, a lack unified description model for irregular design forms leads difficulties in authoring generation, inconveniences data management, low system portability. To address these issues, this paper presents an information-integration instruction-authoring method AA systems. First, guidelines the instructions...
Abstract The sorghum aphid ( Melanaphis sacchari ) has emerged as a serious pest for Sorghum bicolor and major factor limiting its production worldwide. In this study, whole‐genome resequencing of resistant susceptible bulks from recombinant inbred line (RIL) population was conducted together with transcriptome analysis the parent to identify genes underlying resistance. NGS‐based bulked segregation (BSA), using total 920,389 genome‐wide high‐confidence markers, four QTLs, qtlMs‐6.1 ,...
In April 2015, the US Food and Drug Administration approved first generic glatiramer acetate, Glatopa® (M356), as fully substitutable for Copaxone® 20 mg/mL relapsing forms of multiple sclerosis (MS). This approval was accomplished through an Abbreviated New Application that demonstrated equivalence to Copaxone.This article will provide overview methods used establish biological immunological two acetate products, including evaluating antigenpresenting cell (APC) biology, T-cell other...
Abstract Heparan sulfate proteoglycans (HSPGs) play important roles in tumorigenesis by mediating tumor-stromal interactions through the presentation of growth factors, cytokines, and chemokines critical for tumor progression, survival metastasis. M402 is a rationally engineered, non-cytotoxic HSPG mimetic, designed to disrupt tumor-host interactions. binds inhibits multiple factors including VEGF, FGF2, SDF-1α, P-selectin. A single 20 mg/kg subcutaneous (s.c.) dose effectively reduced...