About
Contact & Profiles
A5101977133
Research Areas
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Exercise and Physiological Responses
Albert Einstein College of Medicine
2024
Abstract Aging, chronic high-fat diet feeding, or housing at thermoneutrality induces brown adipose tissue (BAT) involution, a process characterized by reduction of BAT mass and function with increased lipid droplet size. Single nuclei RNA sequencing aged mice identifies specific adipocyte population Ucp1 -low cells that are pyroptotic display in the longevity gene syntaxin 4 ( Stx4a ). Similar to adipocytes, Ucp1-STX4KO loss thermogenic dysfunction concomitant pyroptosis. Restoration STX4...
10.1038/s41467-024-46944-y
article
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Nature Communications
2024-04-02
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