A5101694834- Bladder and Urothelial Cancer Treatments
- Urinary Bladder and Prostate Research
- Renal Diseases and Glomerulopathies
- Pediatric Urology and Nephrology Studies
- Renal cell carcinoma treatment
- Hormonal Regulation and Hypertension
- Genomics, phytochemicals, and oxidative stress
- Dermatology and Skin Diseases
- Urinary and Genital Oncology Studies
- Esophageal Cancer Research and Treatment
- Autoimmune Neurological Disorders and Treatments
- Genetics and Neurodevelopmental Disorders
- Vitamin D Research Studies
- Cancer, Hypoxia, and Metabolism
- Chronic Kidney Disease and Diabetes
- Glutathione Transferases and Polymorphisms
- Magnesium in Health and Disease
- Liver physiology and pathology
- Risk and Safety Analysis
- Epigenetics and DNA Methylation
- Infectious Disease Case Reports and Treatments
- Polyamine Metabolism and Applications
- Cancer Immunotherapy and Biomarkers
- Pituitary Gland Disorders and Treatments
- Vitamin C and Antioxidants Research
Shantou University
2014-2025
Sun Yat-sen University
2020-2025
Second Affiliated Hospital of Shantou University Medical College
2014-2025
Sun Yat-sen University Cancer Center
2020-2025
State Key Laboratory of Oncology in South China
2025
Guangdong Medical College
2023-2024
Affiliated Hospital of Guangdong Medical College Hospital
2023
Xian Central Hospital
2022
Civil Aviation Management Institute of China
2022
Seoul National University
2022
Patients with interstitial cystitis/bladder pain syndrome (IC/BPS) often grieve over a low quality of life brought about by chronic pain. In our previous studies, we determined that neuroinflammation the spinal dorsal horn (SDH) was associated mechanisms cystitis. Moreover, it has been shown brain-derived neurotrophic factor (BDNF) participates in regulation and pathological through BDNF-TrkB signaling; however, whether plays role cyclophosphamide (CYP)-induced cystitis remains unclear. This...
Recent studies have reported that gut microbiota is closely associated with cognitive fuction. Fecal transplantation (FMT) may be a potential treatment for impairment, but its efficacy in patients impairment unknown.This study aimed to investigate the safety and of FMT treatment.Five aged 54-80 years (three women) were enrolled this single-arm clinical trial from July 2021 May 2022. The Montreal Cognitive Assessment-B (MoCA-B), Activities Daily Living (ADL), section Alzheimer's Disease...
Abstract Background Bladder-related pain symptoms in patients with bladder syndrome/interstitial cystitis (BPS/IC) are often accompanied by depression and memory deficits. Magnesium deficiency contributes to neuroinflammation is associated pain, depression, Neuroinflammation involved the mechanical allodynia of cyclophosphamide (CYP)-induced cystitis. Magnesium-L-Threonate (L-TAMS) supplementation can attenuate neuroinflammation. This study aimed determine whether how L-TAMS influences...
Pemphigus vulgaris (PV) is a chronic, often fatal autoimmune blistering disorder that affects the skin and body-wide mucous membranes, imperatively urging for accurate detection of characteristic autoantibodies. To overcome sensitivity constraint, we report here serological avidity test complex PV autoantibodies, relying on cell-based plasmonic biolayer interferometry (cpBLI) with two-tiered enhancement light interference by gold nanostars (AuNSs). High-surface-area, clean-surface AuNSs...
To investigate the correlation between serum levels of decoy receptor 3 (DcR3), neutrophil-to-lymphocyte ratio (NLR), and Fas with prognosis liver cirrhosis, aim providing clinical reference for evaluation cirrhosis. 123 patients cirrhosis were retrospectively selected as observation group, healthy individuals control group. Serum DcR3, Fas, peripheral blood NLR measured compared groups. Differences in these indicators analyzed among varying types those cancer. Receiver operating...
Arrestin domain-containing protein 3 (ARRDC3) is a member of the mammalian α-arrestins family, which has been identified as tumor suppressor gene in human breast cancer, but its functions are still not clear prostate cancer (PCa).The purpose present study was to investigate clinical significance, biological and underlying mechanisms ARRDC3 deregulation PCa.Involvement malignant phenotypes PCa demonstrated by sample evaluation, microarray analysis, vitro vivo experiments. The regulatory...
Abstract Background Percutaneous renal biopsy (PRB) is the primary technique and it was used by 16G needles or 18G in China, but there controversy about effect safety of two different diameters. The study aims to compare adequacy, complication rate pathological classification when using vs. perform with ultrasound-guidedance on native kidneys Chinese individuals. Methods We retrospectively analyzed number glomeruli, adequate sample rates, rates 270 patients use from January 2011 May 2017...
Abstract Background In recent years, simultaneous or sequential occurrence of MOG antibody disease and anti-NMDAR encephalitis in the same patient has been reported with increasing frequency. Scholars refer to overlapping these two disorders as overlap syndrome (MNOS). Cortical T2-weighted fluid-attenuated inversion recovery (FLAIR) -hyperintense lesions anti-MOG-associated seizures (FLAMES) is a rare clinical phenotype MOGAD which cortical FLAIR high-signal are unilateral, little spread...
Lipoprotein glomerulopathy (LPG) is a rare kidney disease with poor prognosis that related to mutation of the apoE gene. More than 10 variants associated LPG have currently been identified. A male and his mother presented proteinuria during health examination. They went hospital for further Renal biopsy was performed, diagnosis lipoprotein (LPG), which rare, inherited renal disease. Medical histories were collected from 2 patients their family members. The members underwent routine urine...
Nuclear receptor coactivators (NCOAs), consisting of and corepressors, dramatically enhance the transcriptional activity nuclear receptors. Hypoxia-inducible factor-1 α (HIF-1 ) is a transcription factor that plays major role under hypoxic conditions. This study was performed with focus on association NCOAs HIF-1 in serum chronic kidney disease (CKD) patients. Sixty patients stage 5 CKD 30 healthy controls from The Second Affiliated Hospital Shantou University Medical College, between March...
Aims. Notch1 signaling regulates microglia activation, which promotes neuroinflammation. Neuroinflammation plays an essential role in various kinds of pain sensation, including bladder-related bladder syndrome/interstitial cystitis (BPS/IC). However, the impact on mechanical allodynia cyclophosphamide- (CYP-) induced is unclear. This study aimed at determining whether and how modulates CYP-induced cystitis. Methods. CYP was peritoneally injected to establish a (BPS/IC) rat model. A...
Background. Hypoxia was considered to be a prognostic indicator in variety of solid tumors. This study aims at identifying the hypoxia-related genes (HRGs) breast cancer (BC) and feasibility HRGs as indicator. Methods. We downloaded mRNA expression data BC patients from TCGA GEO databases. The LASSO Cox regression analysis applied screen hub establish Risk Score. independence Score assessed by multivariate analysis. And immune checkpoint also performed. In addition, we detected level MCF-10A...
Abstract Interstitial cystitis (IC) is a chronic inflammatory disorder characterized by recurring severe pain in the bladder and surrounding pelvic areas, lacking timely diagnostic therapeutic options. Here, we propose unitary theranostic nanocluster-antibody-drug conjugate (NADC) covalently placing dihydroorotate dehydrogenase inhibitors (DHODHi) ultrasmall gold quantum clusters (AuQCs) on nerve growth factor (NGF) antagonistic antibody with simultaneous X-ray computed tomographic...
Relationship between Angiotensin II Type 1 Receptor (AT1R) A1166C gene polymorphism and renal scarring risk is still controversial.This meta-analysis was performed to evaluate the association of AT1R susceptibility.A predefined literature search selection eligible relevant studies were collect data from electronic databases PubMed, Embase Cochrane Library.Three literatures identified included for analysis relationship risk.We found that not associated with susceptibility using comparison...