A5013198607- Blood properties and coagulation
- Nitric Oxide and Endothelin Effects
- Chronic Kidney Disease and Diabetes
- Amino Acid Enzymes and Metabolism
- Birth, Development, and Health
- Erythrocyte Function and Pathophysiology
- Estrogen and related hormone effects
- Connective tissue disorders research
- Hormonal and reproductive studies
- Tissue Engineering and Regenerative Medicine
- Muscle and Compartmental Disorders
- Ion channel regulation and function
- Kidney Stones and Urolithiasis Treatments
First Affiliated Hospital Zhejiang University
2024
Henry Ford Hospital
1992-1996
Beaumont Hospital, Royal Oak
1992
To define the interplay of glomerular hypertension and hypertrophy with mesangial extracellular matrix (ECM) deposition, we examined effects capillary distention cell stretching on ECM synthesis. The volume microdissected rat glomeruli (Vg), perfused ex vivo at increasing flows, was quantified related to proximal intraglomerular pressure (PIP). Glomerular compliance, expressed as slope positive linear relationship between PIP Vg 7.68 x 10(3) microns 3/mmHg. Total increment (PIP 0-150 mmHg)...
Abstract Piezo1 is an essential mechanosensitive transduction ion channel in mammals. Its unique structure makes it capable of converting mechanical cues into electrical and biological signals, modulating (patho)physiological processes a wide variety cells. There increasing evidence demonstrating that the piezo1 plays vital role renal physiology disease conditions. This review summarizes current on properties Piezo1, gating modulation, pharmacological characteristics, with special focus...
Glomerular extracellular matrix accumulation may derive from the stretching of mesangial cells caused by excessive glomerular dilatation. The relationship volume (VG) to intraglomerular pressure, expressed as compliance or mean VG in isolated, perfused rat glomerulus, was used analyze factors that regulate VG. Glomeruli were highly distensible over normal and relevant abnormal range pressure. Compliance increased directly with basal (P < 0.001), i.e., larger glomeruli dilated more than...
Total 4-hydroxyproline content and volume were measured in the same sample of microdissected glomeruli obtained fro rat human outer or inner cortex. Glomerular was determined by computer-assisted image analysis, a highly sensitive gas-liquid chromatographic method. Results expressed as weight basement membrane material comparison with amount purified membrane/mesangial matrix preparations. Microanalyses possible samples containing few eight glomeruli. Rat glomerular size increased sevenfold...