A5050376286- Photosynthetic Processes and Mechanisms
- Algal biology and biofuel production
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Lipid metabolism and biosynthesis
- Monoclonal and Polyclonal Antibodies Research
- Intracranial Aneurysms: Treatment and Complications
- Immune Cell Function and Interaction
- Microbial Community Ecology and Physiology
- Marine and coastal plant biology
- Protist diversity and phylogeny
- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Immunotherapy and Immune Responses
- Remote Sensing and Land Use
- Neurosurgical Procedures and Complications
- Liver Disease Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Meningioma and schwannoma management
- Atmospheric and Environmental Gas Dynamics
- Systemic Lupus Erythematosus Research
- Diabetes and associated disorders
- Cerebrovascular and Carotid Artery Diseases
- Congenital Anomalies and Fetal Surgery
Tokyo University of the Arts
2014-2024
The University of Tokyo
2012-2024
Okayama University
2023-2024
Okayama University Hospital
2022
Okayama Medical Center
2019-2021
National Hospital Organization
2019-2021
Japan Science and Technology Agency
2014-2017
Fujimoto Dental and Oral Surgery Clinic
2017
Toyoda Gosei (Japan)
2012-2016
Japan Aerospace Exploration Agency
1992-2014
Phosphorescence studies of a series facial homoleptic cyclometalated iridium(III) complexes have been carried out. The studied the general structure Ir(III)(C-N)(3), where (C-N) is monoanionic cyclometalating ligand: 2-(5-methylthiophen-2-yl)pyridinato, 2-(thiophen-2-yl)-5-trifluoromethylpyridinato, 2,5-di(thiophen-2-yl)pyridinato, 2,5-di(5-methylthiophen-2-yl)pyridinato, 2-(benzo[b]thiophen-2-yl)pyridinato, 2-(9,9-dimethyl-9H-fluoren-2-yl)pyridinato, 1-phenylisoquinolinato,...
The colonization of land by plants was a key event in the evolution life. Here we report draft genome sequence filamentous terrestrial alga Klebsormidium flaccidum (Division Charophyta, Order Klebsormidiales) to elucidate early transition step from aquatic algae plants. Comparison with that other and demonstrate K. acquired many genes specific We indeed produces several plant hormones homologues some signalling intermediates required for hormone actions higher also encodes primitive system...
The molecular and cellular mechanisms responsible for cytotoxic T lymphocyte (CTL)-induced immunopathology are not well defined. Using a model in which hepatitis B surface antigen (HBsAg)-specific CTL cause an acute necroinflammatory liver disease HBsAg transgenic mice, we demonstrate that class I-restricted pathogenesis is orderly, multistep process involves direct as indirect consequences of activation. It begins (step 1) almost immediately antigen-specific CTL-target cell interaction...
The role of the immune response to hepatitis B virus (HBV)-encoded antigens in pathogenesis liver cell injury has not been defined because absence appropriate experimental models. HBV envelope transgenic mice were used show that HBV-encoded are expressed at hepatocyte surface a form recognizable by major histocompatibility complex (MHC) class I-restricted, CD8 + cytotoxic T lymphocytes specific for dominant epitope within polypeptide and envelope-specific antibodies. Both interactions led...
Abstract. A globally integrated carbon observation and analysis system is needed to improve the fundamental understanding of global cycle, our ability project future changes, verify effectiveness policies aiming reduce greenhouse gas emissions increase sequestration. Building an requires transformational advances from existing sparse, exploratory framework towards a dense, robust, sustained in all components: anthropogenic emissions, atmosphere, ocean, terrestrial biosphere. The paper...
In chronic hepatitis C, Fas expression is up-regulated in the hepatocytes, especially near liver-infiltrating lymphocytes, and ligand expressed on lymphocytes. The presence of C virus (HCV)-specific CTLs has been demonstrated both peripheral blood among lymphocytes patients with C. We studied killing mechanisms HCV-specific human using target cells that were sensitive or resistant to agonistic anti-Fas Abs TNF-alpha. show CTL clones kill non-Ag-bearing bystander as well Ag-bearing cells,...
Abstract Although CD8-positive, class I-restricted CTL play a critical role in viral clearance and immunopathology many model systems, they have not been shown to directly kill their target cells vivo at the single cell level. Using hepatitis B surface Ag transgenic mouse of I-restricted, CTL-mediated liver disease, we now demonstrate that Ld-restricted Ag-specific bind by triggering them undergo degenerative cytologic changes compatible with apoptosis. Unexpectedly, data also indicate...
Abstract T‐cell acute leukemia and lymphoma have a poor prognosis. Although new therapeutic agents been developed, their effects are suboptimal. α‐Pinene, monoterpene compound, has an antitumor effect on solid tumors; however, few comprehensive investigations conducted its impact hematologic malignancies. This report provides analysis of the potential benefits using α‐pinene as agent for treatment tumors. We found that inhibited proliferation malignancies, especially in tumor cell lines EL‐4...
A cytotoxic T lymphocyte (CTL) response to the hepatitis C virus (HCV) nucleoprotein residues 88–96 that are minimal and optimal epitope for human leukocyte antigen (HLA) B44–restricted CTLs was assessed in 27 HLA B44–positive patients with chronic HCV infection. Serum RNA concentration amino acid sequence of 81–100 were also determined. Three infected uncommon substitutions within epitope. One an substitution flanking To stimulate peripheral blood, 9–mer peptides corresponded individual...
Several mice with generalized lymphadenopathy were found in the CBA/KlJms (CBA) colony maintained at our institute. A new mutant strain of that develop massive lymphoid hyperplasia 100% incidence within 5 mo after birth was established by crossing these diseased mice. Genetic studies on conducted F1, F2, and backcross populations from crosses between CBA (CBA-m) various inbred strains The results supported control a single autosomal recessive gene. Since C3H/He-gld/gld (C3H-gld),...
Cytotoxic T lymphocytes have been reported to be involved in the immune clearance of virus-infected cells and pathogenesis viral infection. We studied cytotoxic lymphocyte response putative nucleocapsid protein hepatitis C virus patients with chronic C. specific for were generated from peripheral blood by means repeated stimulation a synthetic peptide. The CD8 positive recognized an epitope residues 81 100 association human leukocyte antigen class I molecule, B44. peptide-induced target...
Both androgen and estrogen receptors were studied in human hepatocellular carcinoma noncancerous liver tissue surrounding it. Androgen receptor was detected the cytosol and/or nucleosol of 4 8 cancerous tissues 1 6 tissues. The levels carcinomas ranged from 3.4 to 37.6 fmoles per mg protein with dissociation constants (K d ) 0.226 − 51.3×10 −9 M . That 2.1 K 0.941×10 Estrogen 7 tissues, while it 3 level 4.9 1.20×10 , those 2.6 1,073 0.223 3.15×10 results suggest that expression may be...
Biophysical parameters and L-band polarimetry synthetic aperture radar observation data were taken for 59 test sites in Tomakomai national forest, which is located the northern part of Japan. Correlations between derived sigma <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">HH</sub> <sup xmlns:xlink="http://www.w3.org/1999/xlink">0</sup> , xmlns:xlink="http://www.w3.org/1999/xlink">HV</sub> xmlns:xlink="http://www.w3.org/1999/xlink">VV</sub>...
ABSTRACT The acyl lipids making up the plastid membranes in plants and algae are highly enriched polyunsaturated fatty acids synthesized by two distinct pathways, known as prokaryotic eukaryotic which located within plastids endoplasmic reticulum, respectively. Here we report results of biochemical well genomic analyses unicellular rhodophyte Cyanidioschyzon merolae . All glycerolipids usually found photosynthetic were found, such mono- digalactosyl diacylglycerol, sulfolipid,...
The precise localization of the lipid droplets and metabolic pathways associated with oil production are crucial to engineering microalgae for biofuel production. Several studies have reported detecting within chloroplast microalga Chlamydomonas reinhardtii, which accumulates considerable amounts triacylglycerol starch cell under nitrogen deprivation or high-light stress conditions. Starch undoubtedly chloroplast, but there been debates on droplets, cytosolic organelles in other organisms....
Hydroxyapatite (HA) is the main constituent of bone mineral, and synthetic HA serves as a biocompatible bioactive material. It permits growth on its surface forms union with adjacent bone.The authors have developed implants made porous HA, which they used in more than 90 cases past 6 years to achieve cervical interbody fusion. The were designed provide maximum durability, biomechanical stability, alignment preservation be technically easy use. summarize their experience results use these...
An epitope that acted as a weak agonist in the cytotoxicity assay was identified part of capsid protein hepatitis C virus (HCV) variant. In low concentration, variant also had antagonistic effect. When minute amount this added to culture for induction, it selectively attenuated expansion major cytotoxic T cell populations and drastically reduced responses against wild-type epitope. Thus, antagonism induction suppressed immune both wild type variant, thereby helping persistence not only...
Chlamydomonas reinhardtii is a model alga for studying triacylglycerol (TAG) accumulation in the photosynthetic production of biofuel. Previous studies were conducted under photoheterotrophic growth conditions medium supplemented with acetate and/or ammonium. We wanted to demonstrate TAG truly photoautotrophic without reduced elements. first reidentified all lipid components and fatty acids by mass spectrometry, because currently used identification knowledge relies on data obtained 1980s....
Pathways of lipid metabolism have been established in land plants, such as Arabidopsis thaliana, but the information on exact pathways is still under study microalgae. In contrast with Chlamydomonas reinhardtii, which currently studied extensively, pathway red algae state enzymes and are estimated by analogy knowledge plants. Here we attempt to construct entire acyl metabolic a model alga, Cyanidioschyzon merolae, an initial basis for future genetic biochemical studies, exploiting...