Next-generation sequencing (NGS) might aid in the identification of causal pathogens. However, optimal approaches applied to cerebrospinal fluid (CSF) for detection are unclear, and studies evaluating application different NGS workflows diagnosis intracranial infections limited.

Soman is a highly toxic organophosphorus nerve agent that can cause persistent neurotoxicity. However, the mechanism of soman-induced neurotoxicity has not been completely clarified. Ferroptosis, novel type programmed cell death, confirmed to precipitate caused by flame retardant. Since studies on relationship between ferroptosis and are lacking, purpose this research explore from perspective ferroptosis. Institute Cancer Research (ICR) mice were injected subcutaneously with low-dose soman...

Tumor recurrence or residual tumor after targeted therapy is common in patients with advanced non-small cell lung cancer (NSCLC). There a lack of high-level evidence on which type treatment should be employed for these and the role salvage surgery has not been well reported literature. A retrospective analysis who underwent our center between January 2016 June 2019 NSCLC was performed. total number nine were identified, including five males four females, median age 56 years (range, 40-65...

Purpose: Listeria monocytogenes infections are rare in the central nervous system (CNS) and frequently difficult-to-diagnose. Our goal is to assess CNS listeriosis patients' clinical characteristics, diagnosis, treatment, prognosis. Patients Methods: with admitted Department of neurology, first medical center Chinese PLA general hospital, were enrolled this study from March 2018 August 2022. Results: This analyzed eight adults, including five males three females. The average age onset was...

To explore the clinical characteristics, surgical treatment and prognosis of non-small cell lung cancer (NSCLC) among elderly patients over 80 years.The data, methods, perioperative management, postoperative complications 52 NSCLC aged years were retrospectively analyzed.Out cases, 27 had a long-term smoking history (51.9%) 44 with other diseases (84.6%). Lobectomy was done in 32 cases (65.4%), sub-lobectomy 20 (38.5%), including pulmonary wedge resection 16 (30.8%) segment 4 (7.7%). The...

Abstract Aims The aim of this study was to assess the influence major transporters at blood–brain barrier and blood–cerebrospinal fluid on levofloxacin (LVFX) pharmacokinetics in rat. To explore different effects drug concentrations cerebrospinal (CSF) brain extracellular (ECF). Methods High‐performance liquid chromatography coupled with microdialysis used continuously synchronously measure unbound LVFX rat blood, hippocampal ECF, lateral ventricle CSF for comprehensive characterization...

Brain-derived neurotrophic factor was utilized in the present study to treat cell injury models induced by aggregated β-amyloid(25-35). Methylthiazolyldiphenyl-tetrazolium bromide assay and western blot analysis showed that brain-derived provided neuroprotection against cellular apoptosis suppressing decline β-amyloid(25-35)-induced activity increasing ratio of Bax/Bcl-2. After treating pheochromocytoma cells with tyrosine kinase receptor B inhibitor K252a, reverses above-mentioned changes....

Abstract Compared with neoadjuvant chemotherapy, concurrent chemoradiotherapy can significantly increase pCR rate and improve overall survival of Locally Advanced ESCC. However, the major pattern failure is distant metastasis, increased risk adverse events surgery. Adding PD-1 inhibitor to chemotherapy have shown significant clinical benefits become standard care for first-line treatment We investigate efficacy safety blockade combined in real world. performed a retrospective, single...

The rise in firm-level cash asset ratios has become a prominent trend countries around the world which may further influence capital allocation efficiency. This study analysed inefficient effect of holdings on by combining internal market theory with principal–agent and asymmetric information theory. theoretical hypotheses were tested using linear panel regression models based financial data from Chinese listed enterprises. We found that corporations holding more assets had lower efficiency...

Community is quickly turning into the aging period, and lung cancer has become more common in elderly patients with malignant tumor. At present, surgery remains preferred therapeutic choice. However, it's worth noting that arrhythmia a complication during perioperative period. The aim of this study to explore risk factors over age 70 years at periods.We retrospectively analyzed 352 who underwent lobectomy or pneumectomy Chinese PLA General Hospital from July 1997 May 2008. Chi-square...

This study presents a CO2 heat pump cycle with vortex tube in which is applied to replace the throttle valve used conventional cycle. The COPh and total heating capacity of this are theoretically investigated compared that for ranges evaporating temperature (−15 3 ℃ ) gas-cooler pressure (8 9.8 MPa). increases increasing nozzle efficiency, effect tube; moreover, decreasing gas cooler outlet cold mass fraction. Under same operating conditions, can be improved by up 3.9 ～ 16.8% over

Neoadjuvant chemoimmunotherapy seems to be a promising treatment option for stage III non-small cell lung cancer (NSCLC). Sintilimab, as programmed death receptor-1 inhibitor, has exhibited fine performance in treating NSCLC. However, the efficiency of sintilimab combined with chemotherapy IIIA/IIIB NSCLC remains inconclusive. The purpose this study was share our experience on neoadjuvant NSCLC.This retrospectively reviewed patients who received surgical resection following 1-3 cycles (200...

To solve the safety hazards caused by easy tilting and manual decoupling of lifting platform, such as large weight, unstable force, uncertain stiffness strength in overall device, according to development status existing spreader, combined with its mechanical structure balance carrying, finite element analysis platform is carried out help ANSYS Workbench software obtain deformation influence force value. After calculating maximum stress value pressure point parameters are determined...

Using Chinese A-share market data, we empirically examine the impact of exchange-traded funds (ETFs) on tail dependence underlying securities. Our results show that ETFs can increase stocks in their basket, showing average a stock is higher when it has stronger holding similarity with other stocks. We investigate role arbitrage activity and find increases stocks' ETF activity. This effect primarily discount rather than premium arbitrage, which leads to among The more significant are...

Lung adenocarcinoma (LUAD) is one of the leading causes cancer-related death worldwide. We identified a specific long non-coding RNA (LncRNA), LINC00908, which was downregulated in LUAD tissues and associated with good outcome. LINC00908 inhibited glycolysis by regulating expression DEAD-box helicase 54 (DDX54), screened nine-gene risk signature, where DDX54 showed positive correlation several glycolysis-related genes. Experimental verification confirmed that regulated nine key glycolytic...

Abstract Based on the ANSYS workbench simulation platform for a lightweight solution, key components of lifting spreader are optimized and analyzed study. Using in conjunction with Solidworks software, following model optimization is carried out based establishing analyzing finite element model. The results show that self-weight reduced by 29.5%, which indicates analysis can keep use same performance high safety factor while reducing their mass density, improving mechanical properties,...