A5090484036- BRCA gene mutations in cancer
- Monoclonal and Polyclonal Antibodies Research
- Genetic factors in colorectal cancer
- T-cell and B-cell Immunology
- Cancer Genomics and Diagnostics
- Immune Cell Function and Interaction
- Genomic variations and chromosomal abnormalities
- Cancer-related Molecular Pathways
- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- DNA Repair Mechanisms
- Glycosylation and Glycoproteins Research
- Immunotherapy and Immune Responses
- Chronic Lymphocytic Leukemia Research
- Blood groups and transfusion
- HIV Research and Treatment
- Immunodeficiency and Autoimmune Disorders
- Cytomegalovirus and herpesvirus research
- Cancer Risks and Factors
- Nutrition, Genetics, and Disease
- Hemophilia Treatment and Research
- Acute Lymphoblastic Leukemia research
- RNA modifications and cancer
- Ovarian cancer diagnosis and treatment
University of Pittsburgh
2024
Ninewells Hospital
2012
University of St Andrews
1996-2012
Western General Hospital
1987-2005
Edinburgh Royal Infirmary
1984-2005
MRC Centre for Reproductive Health
2005
Princess Anne Hospital
2005
Norwegian Cancer Society
2002
University of Aberdeen
1979-2000
Belfast City Hospital
2000
Background : We have previously demonstrated that breast cancers associated with inherited BRCA1 and BRCA2 gene mutations differ from each other in their histopathologic appearances of these types differs patients unselected for family history (i.e., sporadic cancers). now conducted a more detailed examination cytologic architectural features tumors. Methods Specimens tumor tissue (5-µm-thick sections) were examined independently by two pathologists, who unaware the case or control subject...
Studies with two monoclonal antibodies (DA6.147 and DA6.231) which react, respectively, isolated human Ia alpha beta chains are reported. Both detect epitopes expressed on all DR-heterozygous DR-homozygous cell lines tested (n = 17) bind to the Epstein-Barr virus-negative line Ramos. subunit specificity of was determined by an adaptation electroblot technique transfers separated from polyacrylamide gels nitrocellulose paper. In radioimmunobinding assays, peripheral blood B cell-enriched...
To assess the effectiveness of annual ovarian cancer screening (transvaginal ultrasound and serum CA-125 estimation) in detecting presymptomatic women at increased genetic risk.A cohort 1,110 risk were screened between January 1991 March 2004; 553 moderate-risk individuals (4% to 10% lifetime risk) 557 high-risk (> risk). Outcome measurements include number stage screen-detected cancers, cancers not detected screening, equivocal results requiring recall/repetition, undergoing surgery for...
Abstract The p53 locus on the short arm of chromosome 17 at 17p 13.1 was examined for loss heterozygosity, mutation, mRNA and protein expression in 60 primary breast cancers. Allele around detected 19/45 informative tumours (42%). mutations evolutionarily conserved exons 5 to 9 were 17/60 (28%) by amplification mismatch confirmed direct DNA sequencing. Northern blot 36/59 (61%) tumours, using antibody 1801 frozen‐tissue sections 13/44 examined. mutation significantly associated with...
Infection of cervical epithelial cells with so-called "aggressive" subtypes human papilloma virus (HPV) appears to be an important factor in the etiology carcinoma. However, mounting evidence suggests that additional genetic changes are required for progression invasive Functional studies have shown chromosome 11 contains a gene or genes capable suppressing tumorigenicity cell lines derived from different histopathological types carcinoma, suggesting aberration this gene(s) may represent at...
Abstract Eight breast cancer pedigrees with a high probability of containing individuals the BRCA1 gene mutation (odds 79·2–99·9 per cent) were identified through genetic linkage analysis using probes located within q12–22 on long arm chromosome 17. Some 102 female relatives successfully typed one or both adjacent markers D17S588 and D17S579, 41 probable non-BRCA1 carriers. Of remaining 61 women classified as carriers, was diagnosed in 35. As expected from epidemiological segregation...
S ummary . Adrenaline‐induced peripheral blood leucocytosis has been studied in three healthy normal and splenectomized males. An indwelling venous cannula allowed very frequent samples to be obtained before after intramuscular injection of 1 mg adrenaline. It is confirmed that within the first 30 min there a predominant lymphocytosis. Thereafter variable neutrophilia with relative lymphopenia. Evidence was found for more than one peak early We have failed find mechanisms which are involved...
A substantial proportion of women with breast cancer exhibit an abnormally high radiosensitivity as measured by the frequency chromatid breaks induced in G2-phase, PHA stimulated lymphocytes. Chromatid break frequencies were compared for a cohort previously untreated sporadic patients and hospital outpatient controls. In group 46% showed to 14% controls (P< 0.001). Comparison those G2radiosensitivity (G2RS) versus low G2RS no difference menopausal status or age but had on average lower score...
Dedicated clinics have been established for the early diagnosis and treatment of women at risk inherited breast cancer, but effects such interventions are currently unproven. This second report on prospectively diagnosed cancer from European collaborating centres supports previous conclusions adds information genetic heterogeneity effect oophorectomy. Of 249 patients, 20% had carcinoma in situ (CIS), 54% infiltrating without spread (CaN0) 26% with (CaN+). Five-year survival was 100% CIS, 94%...
Abstract Women with a family history of breast cancer are commonly offered regular clinical or mammographic surveillance from age 30. Data on the efficacy such programmes limited. Clinical, pathological and outcome data were recorded all ovarian cancers diagnosed within familial at collaborating centers in Norway UK up to end 2005. These have been analyzed according mutation status affected women ( BRCA1 +ve, BRCA2 +ve mutation‐negative). Breast was 442 patients subsequently followed for...