A5113175884- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Microfluidic and Capillary Electrophoresis Applications
- Advanced biosensing and bioanalysis techniques
- Analytical Chemistry and Chromatography
- Analytical Methods in Pharmaceuticals
- Mass Spectrometry Techniques and Applications
- Electrochemical sensors and biosensors
- Immune Response and Inflammation
- Antibiotics Pharmacokinetics and Efficacy
- Wound Healing and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Drug Solubulity and Delivery Systems
- Nanopore and Nanochannel Transport Studies
- Cancer-related molecular mechanisms research
- Crystallization and Solubility Studies
- Pharmacological Effects of Natural Compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- Viral Infectious Diseases and Gene Expression in Insects
- Microfluidic and Bio-sensing Technologies
- RNA modifications and cancer
- Phytochemistry and biological activity of medicinal plants
- Growth Hormone and Insulin-like Growth Factors
- Analytical Chemistry and Sensors
- Electrospun Nanofibers in Biomedical Applications
University of Debrecen
2025
CHA University
2016-2024
Ewha Womans University
2020-2023
Ewha Womans University Medical Center
2020
Korea Institute of Science and Technology
2003-2019
Advanced Institute of Convergence Technology
2015
Seoul National University
2003-2013
Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș
2004
Wageningen University & Research
1999
Institut Pasteur
1990-1996
Diabetic foot ulcers represent one of the major and rising health issues, as number diabetic patients is increasing. MicroRNAs (miRNAs) are among various bioactive molecules under investigation for wound healing. The prolonged pro-inflammatory phase in wounds partly attributes to its non-healing nature. Therefore, we hypothesized that miRNA-497, known regulation inflammatory responses, would enhance We screened miRNA candidates, including miRNA-497 wounded skin streptozotocin-induced type 1...
Emodin is a component in Chinese herb, Rheum officinale Baill, traditionally used for diabetes and anticancer. Its poor solubility one of the major challenges to pharmaceutical scientists. We previously reported on thermoreversible gel formulations based poloxamer topical delivery emodin. The present study was understand effect type emodin its application cellular activity screening. Various composed 407 (P407), 188 (P188) PEG400 were prepared evaluated. Major evaluation parameters gelation...
SMURF2 is a member of the HECT family E3 ubiquitin ligases that have important roles as negative regulator transforming growth factor-β (TGF-β) signaling through ubiquitin-mediated degradation TGF-β receptor I. However, regulatory mechanism largely unknown. In this study, we identified micro(mi)R-195 and miR-497 putatively target using several prediction databases. Both miR-195 bind to 3'-UTR mRNA inhibit expression. Furthermore, regulate SMURF2-dependent TβRI ubiquitination cause activation...
The transforming growth factor‐β (TGF‐β) signaling pathway is associated with carcinogenesis and various biological processes. SMAD2 SMAD4 , which are putative tumor suppressors, have an important role in TGF‐β signaling. aberrant expression of these genes implicated some cancers. However, the mechanisms dysregulation poorly understood. In this study, we observed that miR‐27a was upregulated lung cancer cell lines patients. addition, were identified as targets by several target prediction...
After spinal cord injury (SCI), neutrophil elastase (NE) released at site disrupts vascular endothelium integrity and stabilization. Angiopoietins (ANGPTs) are growth factors that play an important role in We hypothesized is one of the key determinants disruption/destabilization affects angiopoietins expression after injury. To test this, tubule formation were assessed endothelial cells exposed to different concentrations recombinant neutropil elastase. Then, angiopoietin-1, angiopoietin-2,...
Topical imageplication of epidermal growth fctor (EGF) has been used to accelerate diabetic foot ulcers but with limited efficacy. In this study, we selected a complex coacervate (EGF-Coa) composed the low molecular weight gelatin type A and sodium alginate as novel delivery system for EGF, based on encapsulation efficiency protection EGF from protease. EGF-Coa enhanced in vitro migration keratinocytes accelerated wound healing streptozotocin-induced mice increased granulation...
In a case of hairy cell leukemia, Gordona aurantiaca (Rhodococcus aurantiacus) was isolated from cerebrospinal fluid as the pathogen responsible for lethal infection central nervous system. The had been previously one pulmonary process only.
Abstract Background Cancer is a significant public health issue all over the world. The diagnosis, treatment and follow-up of cancer patients are huge health, economic social burden for societies. link between state country its performance has been proven by numerous studies. aim this study was to examine age-standardized death rate oral in relation development 13 European countries. Methods Aggregated data were collected from Health All (HFA-DB) database until 2019 analysed using second...
Propolis contains a group of compounds with various activities. However, their low solubility is drawback for the development pharmaceutical formulations. In this study, poloxamers as solubilizer and gelling agent were evaluated to develop topical antimicrobial formulation propolis. The effects poloxamer type concentration on propolis solubility, release rate, activities investigated. Staphylococcus aureus (S. aureus) Candida albicans (C. albicans) representative bacteria fungi,...
Abstract An analytical method of CE‐MS and CE with an online preconcentration technique induced by a dynamic pH junction, addition organic solvent large volume injection was developed for sensitive determination peptides in biological samples. Leucine enkephalin, methionine dynorphin A, β‐endorphin angiotensin II were used as model peptides. The optimal conditions obtained at sample matrix consisting 100 mM borate buffer (pH 10.0) 50% v/v acetonitrile BGE containing 1 M formic acid 2.0,...