Mapping of fourteen high-risk human papillomavirus genotypes by molecular detection in sexually active women in the West African sub-region

• DOI: 10.5897/ijgmb2019.0193
• Publication Date: 2020-02-29
• Authors: Théodora MahoukÃ...; Florencia Wendkuu...; Abdoul Karim Ouat...; Ina Marie Angèle ...; Rogomenoma Alice ...; Esther M.A TraorÃ; Prosper Bado; Teega‐Wendé Clari...; Birama Diarra; Maïmouna Ilboudo; Callinice D. Capo...; Dorcas Obiri‐Yeboah; Simplice Damintot...; Mady Nayama; Apollinaire Horo; Kouamé Privat Kou...; Moutawakilou Gomina; Souleymane Ouattara; Ambaliou Sanni; Akpona Simon; Charlemagne Ouédr...; Jacques Simporé

The aim of this study was to determine the distribution high-risk human papillomavirus genotypes (HR-HPV) in women from general population five West African countries. This a cross-sectional descriptive study, involving 2133 nine cities countries: Benin, Burkina Faso, Cote d'Ivoire, Niger and Togo. Women were screened for precancerous cervical lesions HR-HPV infection. detection done by multiplex real-time PCR on extracted viral DNA. average age 35.06 ± 10.00 years with range 15 65 years. overall prevalence HPV infection among sample countries 33.61% (717/2133). dysplasia 8.81%. In decreasing order frequency, found were: 52 followed 31, 59, 51, 66, 45, 68, 56, 58, 35, 39, 18, 33 16. HPV16/18 (bivalent vaccine types) 7.02%. reveals high Africa. extent diversity these deserve special attention prevention.

Key words: High-risk HPV, real time PCR, genotypes, women, epidemiology,