A5016149405- Cervical Cancer and HPV Research
- Hepatitis B Virus Studies
- Genital Health and Disease
- Genetic factors in colorectal cancer
- Glutathione Transferases and Polymorphisms
- Prostate Cancer Treatment and Research
- DNA Repair Mechanisms
- Global Cancer Incidence and Screening
- Hepatitis Viruses Studies and Epidemiology
- Cancer-related Molecular Pathways
- Pneumocystis jirovecii pneumonia detection and treatment
- Parasites and Host Interactions
- Diverse Scientific Research Studies
- Diagnosis and treatment of tuberculosis
- HIV, Drug Use, Sexual Risk
- Drug-Induced Hepatotoxicity and Protection
- Tuberculosis Research and Epidemiology
- HIV/AIDS Research and Interventions
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- RNA Research and Splicing
- BRCA gene mutations in cancer
- T-cell and Retrovirus Studies
- Viral gastroenteritis research and epidemiology
- Advanced Thermodynamic Systems and Engines
Université Joseph Ki-Zerbo
2016-2024
Human papilloma virus (HPV) infection remains a worldwide concern, especially in Sub-Saharan Africa where cervical cancer is the leading cause of death women. The aim study was to determine prevalence and genotypic distribution High-Risk HPV (HR-HPV) involved Cervical Intraepithelial Neoplasia (CIN) II III Parakou. Out total 149 samples tissues archived, fixed paraffin-embedded, 78 with histological diagnosis CIN-II, CIN-III went through deparaffinization xylene, followed by an extraction...
In Sub-Saharan Africa, transfusion safety remains a challenge due to the high endemicity of blood-borne infections. This study aimed determining seroprevalence human immunodeficiency virus (HIV), hepatitis B (HBV), C (HCV), and Treponema pallidum among blood donors in Ouagadougou. was retrospective donor. HIV 1/2 HCV antibodies HBsAg were screened confirmed with two ELISA (Enzyme Linked ImmunoSorbent Assay). While T. also serology tests. Only samples positive for both tests counted as...
Abstract Background The causative agent of cervical cancer referred to as Human papillomavirus (HPV) remains a real public health problem. Many countries in West Africa, such Togo have no data on the high-risk HPV (HR-HPV) infection and genotypes distribution. In order fill knowledge gap field Togo, main objective this study was determine prevalence pre-cancerous lesions cervix HR-HPV among Togolese women. Methods Samples were collected from 240 women by introducing swab cervix. Then,...
Abstract Introduction Genital human papillomavirus (HPV) infection is widespread among sexually active individuals. Several factors may contribute to increased risk of in pregnant women. The objective this study was determine the high-risk (HR-HPV) and low-risk (LR-HPV) oncogenic HPV genotypes women Ouagadougou. Methodology In study, 100 endocervical samples were collected using a sterile swab on examination glove used during vaginal DNA from each sample amplified by PCR followed...
Abstract Background Genetic alterations can result in DNA repair defects, increasing susceptibility to breast cancer. The aim of this study was evaluate the involvement two genes, ERCC1 ( rs3212986, GenBank NC_000073.9) and ERCC2 rs1799793, rs13181 , GenBank: NC_000019.10 ) occurrence cancer Burkina Faso. Methods This case–control enrolled 128 participants including 64 patients healthy controls. Genotyping polymorphisms were performed by real‐time PCR PCR‐RFLP. Results heterozygous AC...
Abstract Background Prostate cancer (Pca) is a public health problem that affects men, usually of middle age or older. It the second most common diagnosed in men and fifth leading cause death. The RNASEL gene located 1q25 identified as susceptibility to hereditary prostate cancer, has never been studied relation Burkina Faso. aim this study was analyze carriage R462Q D541E mutations risks factors patients with Methods This case–control included 38 histologically cases 53 controls (cases...
Abstract Genetic alterations in the TP63 (GenBank: NC_000003.12, ID: 8626) and CCR5 (receptor 5 chemokine co-receptor) 1234) genes may increase risk of developing breast cancer. The aim this study was to investigate probable involvement polymorphisms rs17506395 (tumour protein 63) gene CCR5Δ32 mutation occurrence cancer Burkina Faso. This case–control included 72 patients controls. Genotyping SNP (TP63) performed by polymerase chain reaction–restriction fragment length polymorphism,...
Introduction: The TP53 and CHEK2 genes have been described as breast cancer susceptibility some of their polymorphisms associated with an increased risk in certain populations.Aim: objective this study was to investigate the p.R72P PIN3 Ins16bp (TP53) I157T (CHEK2) mutation developping cancer. Methods: This case-control had enrolled 144 participants including 65 cases (breast patients) 79 controls (women without abnormalities) city Ouagadougou Burkina Faso. DNA extracted using method...
The aim of this study was to determine the distribution high-risk human papillomavirus genotypes (HR-HPV) in women from general population five West African countries. This a cross-sectional descriptive study, involving 2133 nine cities countries: Benin, Burkina Faso, Cote d'Ivoire, Niger and Togo. Women were screened for precancerous cervical lesions HR-HPV infection. detection done by multiplex real-time PCR on extracted viral DNA. average age 35.06 ± 10.00 years with range 15 65 years....
Although persistence of high-risk human papillomavirus infection is the main risk factor, Glutathione S-Transferase highly polymorphic enzyme involved in metabolism xenobiotics, a good candidate gene. The objective this study was to compare polymorphisms M1-null women with cancerous lesions and without lesions. This consisted 322 uterine cervix samples from Mali Burkina Faso Cervical Intra-epithelial Neoplasia 2 3, adenocarcinoma squamous cell carcinoma 100 no Human Papillomavirus genotyping...
Background. Genetic factors are one of the significant contributors to prostate cancer (PCa) development, and hereditary 2 (HPC2) locus gene ELAC2 is considered a PCa susceptibility region. The HPC2/ELAC2 has been identified by linkage analysis in familial patients United States but never studied Burkina Faso. objective present study was analyze carriage C650T (Ser217Leu) G1621A (Ala541Thr) mutations risk Methods. This case-control included 76 participants, including 38 histologically...
Abstract Background The clinical manifestations of coronavirus disease (COVID-19) can vary widely, ranging from asymptomatic to severe, and may be influenced by the host genetic background. aim present study was determine frequencies HLA-DRB1*11 HLA-DRB1*12 allele polymorphisms their associations with COVID-19. Methods In this cross-sectional study, 198 subjects were enrolled, including 150 COVID-19 positive cases 48 who tested negative for Participants recruited emergency, intensive care,...
Introduction: Genetic polymorphisms of some Glutathione S-Transferase (GST) which encode the enzyme responsible for biotransformation drugs and xenobiotics, have been associated with risk several pathologies that can progress to cancer such as Hepatitis B. This study aims characterize impact rs1695 polymorphism GSTP1 gene among people chronic B infection in Burkina Faso. Methods: genotyping was performed 50 infected virus 124 healthy PCR-RFLP method. Conventional PCR used DNA amplification...
This study aims to comprehensively review the literature pertaining management of liver diseases, especially cirrhosis in sub-Saharan Africa. Specifically, it involves a meticulous synthesis and analysis data concerning physiopathology cirrhosis, an assessment clinical manifestations associated with condition, exploration presence efficacy therapeutic approaches utilizing conventional medicinal plants. The present investigation included studies published between 2017 2022, focusing on...