A5089304651- Glutathione Transferases and Polymorphisms
- BRCA gene mutations in cancer
- Nutrition, Genetics, and Disease
- Immune Cell Function and Interaction
- Genetic factors in colorectal cancer
- Hepatitis B Virus Studies
- DNA Repair Mechanisms
- Hepatitis C virus research
- T-cell and B-cell Immunology
- Liver Disease Diagnosis and Treatment
- Fungal Infections and Studies
- Genomics, phytochemicals, and oxidative stress
- T-cell and Retrovirus Studies
- Immunotherapy and Immune Responses
- Chronic Lymphocytic Leukemia Research
- Global Cancer Incidence and Screening
- Cervical Cancer and HPV Research
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Parvovirus B19 Infection Studies
- Antifungal resistance and susceptibility
- Genomic variations and chromosomal abnormalities
- Viral-associated cancers and disorders
Université Joseph Ki-Zerbo
2019-2024
Joseph Ayo Babalola University
2023
Vulvovaginal candidiasis is an important cause of morbidity among women due to Candida species. In the last decades, resistance azoles, first-line antifungals has increased. One molecular mechanism azole by involves mutations in ERG11 gene encoding lanosterol 14-α-demethylase, target enzyme. This study was conducted identify clinical species associated vulvovaginal candidiasis; determine rate antifungal albicans isolates and mutated at Saint Camille Hospital Ouagadougou, Burkina...
Abstract Objectives A cluster of specialized KIR genes has been shown to be associated with susceptibility or resistance viral infections in humans. Therefore, this pilot study, investigation sought determine the frequencies human immunodeficiency virus type 1( HIV-1) patients and establish their potential clinical involvement disease progression staging. Methods HIV-1 infected healthy individuals were selected for study. Hepatitis B surface antigen (HBsAg), anti-HCV antibodies anti-HIV-1/2...
Hepatitis B virus (HBV) genotype E (HBV‐E) accounts for the majority of chronic hepatitis (CHB) infections in West Africa. We aimed to determine factors associated with HBV‐E‐induced hepatocellular carcinoma (HCC) Data on patients from Burkina Faso who were surface antigen positive (HBsAg+) and had CHB analyzed. HBV viral load e (HBeAg) status measured 3,885 individuals without HCC (CHB HCC−) 59 HCC+). genotyping was performed 364 subjects HCC− 41 HCC+. Overall, 2.5% group HBeAg+ compared 0%...
Background and objective Breast cancer remains the most common cause of mortality in women. The aim this study was to investigate associations between genetic variability GSTM1 GSTT1 susceptibility breast cancer. Methods Genomic DNA extracted from blood samples for 80 cases histologically diagnosed 100 control subjects. Genotyping analyses were performed by PCR-based methods. Associations specific genotypes development examined using logistic regression calculate odds ratios [1] 95%...
Abstract Background Glutathione S-transferases play a key role in the detoxification of persistent oxidative stress products which are one several risks factors that may be associated with many types disease processes such as cancer, diabetes, and hypertension. In present study, we characterize null genotypes GSTM1 GSTT1 order to investigate association between them risk developing essential Methods We conducted case-control study Burkina Faso, including 245 subjects hypertension case 269...
Abstract Several factors contribute to the development of breast cancer, including immune system. This study is aimed characterize carriage human leukocyte antigen (HLA)-DRB1*11 and 1*12 alleles in patients with cancer. case-control consisted 96 histologically diagnosed cancer cases 102 controls (cases without abnormalities). A multiplex polymerase chain reaction (PCR) was used HLA-DRB1*11 alleles. The allele present 26.59% 22.55% controls. HLA-DRB1*12 56.63% 55.88% found no direct...
Abstract Background Genetic alterations can result in DNA repair defects, increasing susceptibility to breast cancer. The aim of this study was evaluate the involvement two genes, ERCC1 ( rs3212986, GenBank NC_000073.9) and ERCC2 rs1799793, rs13181 , GenBank: NC_000019.10 ) occurrence cancer Burkina Faso. Methods This case–control enrolled 128 participants including 64 patients healthy controls. Genotyping polymorphisms were performed by real‐time PCR PCR‐RFLP. Results heterozygous AC...
Abstract Genetic alterations in the TP63 (GenBank: NC_000003.12, ID: 8626) and CCR5 (receptor 5 chemokine co-receptor) 1234) genes may increase risk of developing breast cancer. The aim this study was to investigate probable involvement polymorphisms rs17506395 (tumour protein 63) gene CCR5Δ32 mutation occurrence cancer Burkina Faso. This case–control included 72 patients controls. Genotyping SNP (TP63) performed by polymerase chain reaction–restriction fragment length polymorphism,...
A facile colorimetric method has been developed for the detection of single-nucleotide mutations based on rolling circle amplification and G-quadruplex-based DNAzyme.
Introduction: The TP53 and CHEK2 genes have been described as breast cancer susceptibility some of their polymorphisms associated with an increased risk in certain populations.Aim: objective this study was to investigate the p.R72P PIN3 Ins16bp (TP53) I157T (CHEK2) mutation developping cancer. Methods: This case-control had enrolled 144 participants including 65 cases (breast patients) 79 controls (women without abnormalities) city Ouagadougou Burkina Faso. DNA extracted using method...
The objective of this study is to search for mutations in the BRCA1 (c.5177_5180delGAAA and c.4986+6T>C) BRCA2 genes (c.6445_6446delAT) a population women diagnosed with breast cancer.This case-control that involved 140 participants, including 70 patients histologically cancer healthy without cancer. Mutations (rs80357867, rs80358086) (rs80359592) were tested by real-time PCR. 95% confidence interval Odds Ratio (OR) was used estimate associations between specific genotypes cancer.The...
Background: Glutathione S-transferases (GSTs) are multifunctional enzymes which play an important role in oxidative stress pathways by conjugation with glutathione. Oxidative is one of several risk factors that may be associated many types diseases progression such as cancer and infectious diseases. In this study, we investigated the association between polymorphism GSTM1 GSTT1 genes HIV-1 disease progression. Methods: We conducted a case-control study including 313 participants Burkina...
Glutathione S-transferases have been associated with experimental resistance to some drugs. The present study investigated the factors blood pressure control in patients essential hypertension, especially role of GSTT1 and GSTM1 genes polymorphisms. This cross-sectional Burkina Faso consisted 200 hypertension under treatment.In study, 57.5% (115/200) had their control. No statistically significant difference was found between controlled uncontrolled groups for anthropometric biochemical...
Hepatitis C virus (HCV) infection remains a major public health problem worldwide. In Burkina Faso, nearly 720,000 people are living with HCV, and each year about 900 die from complications of cirrhosis or hepatocellular carcinoma. This study was planned to determine the HCV seroprevalence, characterize circulating genotypes, monitor viral loads in patients under treatment antivirals.A total 4,124 individuals 167 pre-therapy program were recruited. The "SD Bioline HCV" kit used for rapid...
Breast cancer is the leading cause of death among women in both developed and developing countries. It multifactorial, including genetic predispositions such as oncogenic mutations on BRCA1 2 genes. The objectives present study were to identify exon 11 gene determine risk factors for breast population Burkina Faso. This involved 100 women, 50 cases controls (no clinical signs no family history or other cancers). Mutations detected by PCR using sequence primers specific fragments (11.1 11.2)....
Occult hepatitis B infection (OBI) is a public health problem in Burkina Faso. OBI represents risk factor for the development of cirrhosis and hepatocellular carcinoma (HCC). could be due to mutant viruses undetectable by HBsAg assays or strong suppression viral replication gene expression under pression host immune system. To investigate role killer cell immunoglobulin‑like receptor (KIR) polymorphisms patients with Faso compared healthy chronic subjects. A total 286 participants was...
Abstract ObjectiveGlutathione S-transferases have been associated with experimental resistance to some drugs. The present study investigated the factors blood pressure control in patients essential hypertension, especially role of GSTT1 and GSTM1 genes polymorphisms. This cross-sectional Burkina Faso consisted 200 hypertension under treatment. ResultsThis population 57.5 % (115/200) their control. No statistically significant difference ( p > 0.05) was found between controlled...
Human herpesvirus type 8 (HHV-8) is the main etiological agent of Kaposi's sarcoma. This virus frequently associated with immunocompromision. study aimed to detect HHV-8 in people compromised immune system.This a cross-sectional that included 180 subjects: 179 HIV-infected patients and 1 patient bullous pemphigoid. Blood samples were taken from all subjects, swabs lesions then individuals symptoms Viral load CD4+ T lymphocytes count performed for persons living HIV real-time PCR detection...