A5079663816- Glutathione Transferases and Polymorphisms
- Immune Cell Function and Interaction
- Hepatitis B Virus Studies
- Prostate Cancer Treatment and Research
- BRCA gene mutations in cancer
- Cancer-related Molecular Pathways
- T-cell and B-cell Immunology
- DNA Repair Mechanisms
- Nutrition, Genetics, and Disease
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- RNA Research and Splicing
- HIV/AIDS Research and Interventions
- Global Cancer Incidence and Screening
- Cell Adhesion Molecules Research
- Cancer-related gene regulation
- Diabetes and associated disorders
- Genomics, phytochemicals, and oxidative stress
- Reproductive tract infections research
- Cancer Risks and Factors
- SARS-CoV-2 and COVID-19 Research
- Glaucoma and retinal disorders
- Genetic factors in colorectal cancer
- Female Genital Mutilation/Cutting Issues
- HIV/AIDS drug development and treatment
Université Joseph Ki-Zerbo
2018-2023
Joseph Ayo Babalola University
2022-2023
Institut de Recherche en Sciences de la Santé
2023
Abstract Objectives A cluster of specialized KIR genes has been shown to be associated with susceptibility or resistance viral infections in humans. Therefore, this pilot study, investigation sought determine the frequencies human immunodeficiency virus type 1( HIV-1) patients and establish their potential clinical involvement disease progression staging. Methods HIV-1 infected healthy individuals were selected for study. Hepatitis B surface antigen (HBsAg), anti-HCV antibodies anti-HIV-1/2...
Genetic and environment play a significant role in the etiology of essential hypertension (EH). Recently STK39 rs3754777, ATP2B1 rs2681472 rs17249754 have been associated with BP variation hypertension. In this study we aimed to determine firstly whether index variants were risk developing EH Burkina Faso secondly characterize cardiovascular markers. We conducted case-control 380 participants including 180 case subjects 200 control normal BP. used TaqMan genotyping assays probes from Applied...
Hepatitis B virus (HBV) infection is the leading risk factor for cirrhosis and hepatocellular carcinoma (HCC). The objective of this investigation was to assess association between "Killer Cell Immunoglobulin-Like Receptor" (KIR) gene frequencies chronic HBV infection.Chronic carriers healthy patients were selected study. viral load performed, SSP-PCR used characterize KIR genes.The study suggested that inhibitory genes KIR2DL2 (crude OR = 2.82; p < 0.001), KIR2DL3 2.49; 0.001) activator...
Background and objective Breast cancer remains the most common cause of mortality in women. The aim this study was to investigate associations between genetic variability GSTM1 GSTT1 susceptibility breast cancer. Methods Genomic DNA extracted from blood samples for 80 cases histologically diagnosed 100 control subjects. Genotyping analyses were performed by PCR-based methods. Associations specific genotypes development examined using logistic regression calculate odds ratios [1] 95%...
Abstract Background Glutathione S-transferases play a key role in the detoxification of persistent oxidative stress products which are one several risks factors that may be associated with many types disease processes such as cancer, diabetes, and hypertension. In present study, we characterize null genotypes GSTM1 GSTT1 order to investigate association between them risk developing essential Methods We conducted case-control study Burkina Faso, including 245 subjects hypertension case 269...
Abstract Several factors contribute to the development of breast cancer, including immune system. This study is aimed characterize carriage human leukocyte antigen (HLA)-DRB1*11 and 1*12 alleles in patients with cancer. case-control consisted 96 histologically diagnosed cancer cases 102 controls (cases without abnormalities). A multiplex polymerase chain reaction (PCR) was used HLA-DRB1*11 alleles. The allele present 26.59% 22.55% controls. HLA-DRB1*12 56.63% 55.88% found no direct...
Abstract Background Genetic alterations can result in DNA repair defects, increasing susceptibility to breast cancer. The aim of this study was evaluate the involvement two genes, ERCC1 ( rs3212986, GenBank NC_000073.9) and ERCC2 rs1799793, rs13181 , GenBank: NC_000019.10 ) occurrence cancer Burkina Faso. Methods This case–control enrolled 128 participants including 64 patients healthy controls. Genotyping polymorphisms were performed by real‐time PCR PCR‐RFLP. Results heterozygous AC...
Abstract Background Prostate cancer (Pca) is a public health problem that affects men, usually of middle age or older. It the second most common diagnosed in men and fifth leading cause death. The RNASEL gene located 1q25 identified as susceptibility to hereditary prostate cancer, has never been studied relation Burkina Faso. aim this study was analyze carriage R462Q D541E mutations risks factors patients with Methods This case–control included 38 histologically cases 53 controls (cases...
Introduction: antiretroviral therapy enables the suppression of plasma viral load and restoration immune responses. Therapeutic failures are still observed in patients living with HIV despite considerable benefits therapy. This study aimed to describe long-term evolution immunological virological parameters undergoing treatments for HIV-1 at Day Hospital Bobo-Dioulasso Burkina Faso.
Introduction: The TP53 and CHEK2 genes have been described as breast cancer susceptibility some of their polymorphisms associated with an increased risk in certain populations.Aim: objective this study was to investigate the p.R72P PIN3 Ins16bp (TP53) I157T (CHEK2) mutation developping cancer. Methods: This case-control had enrolled 144 participants including 65 cases (breast patients) 79 controls (women without abnormalities) city Ouagadougou Burkina Faso. DNA extracted using method...
The objective of this study is to search for mutations in the BRCA1 (c.5177_5180delGAAA and c.4986+6T>C) BRCA2 genes (c.6445_6446delAT) a population women diagnosed with breast cancer.This case-control that involved 140 participants, including 70 patients histologically cancer healthy without cancer. Mutations (rs80357867, rs80358086) (rs80359592) were tested by real-time PCR. 95% confidence interval Odds Ratio (OR) was used estimate associations between specific genotypes cancer.The...
Background: Glutathione S-transferases (GSTs) are multifunctional enzymes which play an important role in oxidative stress pathways by conjugation with glutathione. Oxidative is one of several risk factors that may be associated many types diseases progression such as cancer and infectious diseases. In this study, we investigated the association between polymorphism GSTM1 GSTT1 genes HIV-1 disease progression. Methods: We conducted a case-control study including 313 participants Burkina...
Glutathione S-transferases have been associated with experimental resistance to some drugs. The present study investigated the factors blood pressure control in patients essential hypertension, especially role of GSTT1 and GSTM1 genes polymorphisms. This cross-sectional Burkina Faso consisted 200 hypertension under treatment.In study, 57.5% (115/200) had their control. No statistically significant difference was found between controlled uncontrolled groups for anthropometric biochemical...
Hepatitis C virus (HCV) infection remains a major public health problem worldwide. In Burkina Faso, nearly 720,000 people are living with HCV, and each year about 900 die from complications of cirrhosis or hepatocellular carcinoma. This study was planned to determine the HCV seroprevalence, characterize circulating genotypes, monitor viral loads in patients under treatment antivirals.A total 4,124 individuals 167 pre-therapy program were recruited. The "SD Bioline HCV" kit used for rapid...
Background. Genetic factors are one of the significant contributors to prostate cancer (PCa) development, and hereditary 2 (HPC2) locus gene ELAC2 is considered a PCa susceptibility region. The HPC2/ELAC2 has been identified by linkage analysis in familial patients United States but never studied Burkina Faso. objective present study was analyze carriage C650T (Ser217Leu) G1621A (Ala541Thr) mutations risk Methods. This case-control included 76 participants, including 38 histologically...
Occult hepatitis B infection (OBI) is a public health problem in Burkina Faso. OBI represents risk factor for the development of cirrhosis and hepatocellular carcinoma (HCC). could be due to mutant viruses undetectable by HBsAg assays or strong suppression viral replication gene expression under pression host immune system. To investigate role killer cell immunoglobulin‑like receptor (KIR) polymorphisms patients with Faso compared healthy chronic subjects. A total 286 participants was...
Abstract Background The clinical manifestations of coronavirus disease (COVID-19) can vary widely, ranging from asymptomatic to severe, and may be influenced by the host genetic background. aim present study was determine frequencies HLA-DRB1*11 HLA-DRB1*12 allele polymorphisms their associations with COVID-19. Methods In this cross-sectional study, 198 subjects were enrolled, including 150 COVID-19 positive cases 48 who tested negative for Participants recruited emergency, intensive care,...
Introduction: Genetic polymorphisms of some Glutathione S-Transferase (GST) which encode the enzyme responsible for biotransformation drugs and xenobiotics, have been associated with risk several pathologies that can progress to cancer such as Hepatitis B. This study aims characterize impact rs1695 polymorphism GSTP1 gene among people chronic B infection in Burkina Faso. Methods: genotyping was performed 50 infected virus 124 healthy PCR-RFLP method. Conventional PCR used DNA amplification...
Glaucoma is a group of degenerative diseases the optic nerve whose predisposing factors may be genetic. The objective this study was to estimate frequency Glu323Lys mutation as genetic risk factor for glaucoma.A cross-sectional over 6 months from October 2020 March 2021 in Ouagadougou, Burkina Faso. A total 89 samples patients with primary open-angle glaucoma (POAG) were collected. myocilin, trabecular meshwork inducible glucocorticoid response (TIGR/MYOC) gene by polymerase chain reaction...
Recent genome-wide association studies and replication analyses have reported the of variants exostosin- 2 gene (EXT2) risk type diabetes (T2D) in some populations, but not others. This study aimed to characterize rs1113132, rs3740878 rs11037909 EXT2 determine existence a possible correlation with T2D Burkina Faso. It is case-control undertaken Faso city Ouagadougou at Hospital Saint Camille from December 2014 June 2015. relates 121 cases 134 controls. The genotyping these polymorphisms was...
Abstract Background: The TP53 and CHEK2 genes have been described as breast cancer susceptibility some of their polymorphisms associated with an increased risk in certain populations. objective this study was to investigate the p.R72P PIN3 Ins16bp (TP53) I157T (CHEK2) mutation . Methods results: This case-control had enrolled 144 participants including 65 cases (breast patients) 79 controls (women without abnormalities). genotyping performed by ASO-PCR (Allele Specific Oligonucleotides -...
Abstract Background Prostate cancer (Pca) is a public health problem that affects men, usually of middle age or older. It the second most common diagnosed in men and fifth leading cause death. The RNASEL gene located 1q25 identified as susceptibility to hereditary prostate cancer, has never been studied relation Burkina Faso. aim this study was analyze carriage R462Q D541E mutations risks factors patients with Methods This case-control included 38 histologically cases 53 controls (cases...