A5087310908- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Retinal Imaging and Analysis
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- Cancer-related Molecular Pathways
- Prostate Cancer Treatment and Research
- DNA Repair Mechanisms
Université Joseph Ki-Zerbo
2022-2023
Institut de Recherche en Sciences de la Santé
2023
Abstract Background Genetic alterations can result in DNA repair defects, increasing susceptibility to breast cancer. The aim of this study was evaluate the involvement two genes, ERCC1 ( rs3212986, GenBank NC_000073.9) and ERCC2 rs1799793, rs13181 , GenBank: NC_000019.10 ) occurrence cancer Burkina Faso. Methods This case–control enrolled 128 participants including 64 patients healthy controls. Genotyping polymorphisms were performed by real‐time PCR PCR‐RFLP. Results heterozygous AC...
Introduction: The TP53 and CHEK2 genes have been described as breast cancer susceptibility some of their polymorphisms associated with an increased risk in certain populations.Aim: objective this study was to investigate the p.R72P PIN3 Ins16bp (TP53) I157T (CHEK2) mutation developping cancer. Methods: This case-control had enrolled 144 participants including 65 cases (breast patients) 79 controls (women without abnormalities) city Ouagadougou Burkina Faso. DNA extracted using method...
Background. Genetic factors are one of the significant contributors to prostate cancer (PCa) development, and hereditary 2 (HPC2) locus gene ELAC2 is considered a PCa susceptibility region. The HPC2/ELAC2 has been identified by linkage analysis in familial patients United States but never studied Burkina Faso. objective present study was analyze carriage C650T (Ser217Leu) G1621A (Ala541Thr) mutations risk Methods. This case-control included 76 participants, including 38 histologically...
Glaucoma is a group of degenerative diseases the optic nerve whose predisposing factors may be genetic. The objective this study was to estimate frequency Glu323Lys mutation as genetic risk factor for glaucoma.A cross-sectional over 6 months from October 2020 March 2021 in Ouagadougou, Burkina Faso. A total 89 samples patients with primary open-angle glaucoma (POAG) were collected. myocilin, trabecular meshwork inducible glucocorticoid response (TIGR/MYOC) gene by polymerase chain reaction...