The association of malignant neoplasms arising contiguous with or adjacent to seborrheic keratoses has been previously documented. In this study a retrospective analysis was performed further characterize these combined neoplasms. A total 54 examples in conjunction were found, which 43 basal cell carcinomas, six Bowen's disease, three keratoacanthomas, and two melanomas. average age the patients over 65 years. Men affected more frequently then women. posterior thorax most common site for...

Abstract The common gamma-chain (gamma(c)) is a functional component of the IL-4R, yet cells lacking gamma(c) are able to respond IL-4. This has led suggestion that surrogate gamma'-chain, which can interact with IL-4R alpha chain mediate signaling, expressed on gamma(c). An alternative possibility in absence gamma(c), transduce signals by homodimerization. To test this latter possibility, chimeric receptor containing extracellular domain c-kit (the stem cell factor (SCF) receptor) and...

The purpose of the study was to investigate associations between biomechanical resilience (failure load, failure strength) and microarchitecture cancellous bone in vertebrae human cadavers with low density or without vertebral fractures (VFx).Spines were removed from 13 body donors (approval no. A 2017-0072) analyzed regard mineral (BMD), Hounsfield units (HU), fracture count (Fx) aid high-resolution CT images. This followed by puncture bodies C2 L5 using a Jamshidi™ needle. following...

Tyrosine phosphorylation of STAT6 in response to IL-4 results the formation homodimers that bind specific DNA elements. Although binding sites for have been shown be important function several IL-4-inducible promoters, role this activation has not defined. To determine whether is a transcriptional activator, different portions carboxyl terminus were fused yeast Gal4 protein domain. Analysis these chimeric Gal4-STAT6 proteins demonstrates 140-amino-acid proline-rich region contains activates...

Abstract Decreasing alcohol in beer and increasing the pleasure of lower beers is a potential way to limit total consumption. Consumers’ willingness drink alcohol‐reduced mainly limited by unfavorable flavor characteristics that arise during To investigate temporal dominance consumption, we analyzed five most dominant flavors from nine different among three types with varying content assess Flavor Life Cycle. Results show displayed similar (e.g., bitterness) differences worty‐off flavor,...

We describe two cases of a malignant cutaneous neoplasm with combined phenotypical features high-grade basal cell carcinoma and melanoma. Some tumor cells showed keratinocytic phenotype (cytokeratins, p63) others melanocytic (HMB-45, MART-1, Melan-A, S100-protein). favor the hypothesis bidirectional differentiation, an exceptionally rare event.

Preservation of mobility in conjunction with an independent life style is one the major goals rehabilitation after stroke.The Rehab@Home framework shall support continuation at home.The consists instrumented insoles, connected wirelessly to a 3G ready tablet PC, server, and web-interface for medical experts. The progress estimated via automated analysis movement data from standardized assessment tests which are designed according needs stroke patients executed PC application.The framework's...

PURPOSE: To evaluate a fast three-dimensional (3D) sequence that permits the acquisition of 16 T2-weighted images within 29-second breath hold for magnetic resonance (MR) imaging liver. MATERIALS AND METHODS: Eighty-seven patients with focal liver lesions were examined at 1.5 T by using 3D reversed steady-state precession (PSIF) flip angles 15 degrees, 30 and 70 degrees spin-echo (SE) sequence. Quantitative qualitative image analysis was performed. RESULTS: Contrast signal...

A proof of concept for the evaluation external nerve and muscle fiber excitation with finite element software COMSOL Multiphysics, formerly known as FEMLAB, is presented. This allows simultaneous solution by 1D models Hodgkin-Huxley type which are embedded in a volume conductor where electric field mainly dominated electrode currents. way presented bidomain model includes interaction between currents transmembrane during process. Especially direct stimulation (cardiac muscle, denervated...

Abstract: Functional electrical stimulation (FES) of long‐term denervated, degenerated human skeletal muscle has proven to be a suitable method for improving number physiological parameters. The underlying mechanisms activation denervated fiber can described with suitably modified and extended Hodgin‐Huxley type models, coupled three‐dimensional (3D) finite element models the surrounding field. Regions within determined using 3D computer model. However, simulation results have not yet been...

Abstract In order to perform long-term, low-effort gait analysis an instrumented shoe insole, equipped with embedded data processing system, a variety of sensors and wireless transmission module has been developed. By using specially developed signal fusion algorithms, the sensor’s raw data, like pressure, 3D tilt acceleration, is processed provide information about user’s or moving behaviour. This insole will also form basis “easy use” balance training system for older people, in help...

A case of inflammatory carcinoma, or carcinoma erysipelatodes, clinically resembling erythema annulare centrifugum is reported. The cutaneous was due to metastasis by a signet-ring cell adenocarcinoma, probably gastrointestinal origin. This the third reported with infiltration. Cancer patients atypical unusual dermatoses should be evaluated skin biopsy because possible association internal neoplastic process.

In response to the SARS-CoV-2 pandemic, 2 messenger RNA (mRNA) lipid-stabilized vaccines involving new technologies have been launched with unprecedented urgency. Early postrelease data shown these be extremely effective and safe. Some reports emerged suggesting that second dose of Moderna (mRNA-1273) vaccine can cause adverse dermatologic reactions. This article describes a series both localized generalized mild cutaneous reactions in community-based outpatient dermatology practice.

Ultrasound contrast agents (US-CA) amplify reflected sound waves. Most substances used as are destroyed when passing the lungs. SH U 508 is a new US-CA that can pass lungs without impairment after peripheral intravenous application. In clinical trial of this US-CA, we investigated its effect on visualization blood movement in arteries by color-coded Duplex sonography (CCDS). The leg 20 patients with severe chronic arterial occlusion were examined CCDS (QAD I and Platinum) i.v. application...

Food cues affect hunger and nutritional choices. Omnipresent stimulation with palatable food contributes to the epidemics of obesity. The objective study was investigate impact on appetite-related hormones assess functionality secreted macronutrient uptake in healthy subjects. Additionally, we aimed at verifying differences response total active ghrelin pictures a meal followed by stimulation. We were also interested identification factors contributing cues. recruited healthy, non-obese...

<h3>To the Editor.—</h3> We describe a patient with acquired immunodeficiency syndrome (AIDS) in whom acrodermatitis enteropathica and an essential fatty acid deficiency developed. The development of zinc this was due to AIDS nephropathy proteinuria excessive loss protein-bound zinc. Zinc leads impairment humoral cell-mediated immunity may play important role or worsening AIDS. <h3>Report Case.—</h3> A 32-year-old white woman history intravenous drug abuse membranoproliferative...

Abstract: Optimization of stimulation parameters as well shape and positioning electrodes are important questions in functional electrical (FES) paraplegic patients. For that reason a MATLAB tool, called FES‐FIELD, modeling the three‐dimensional electric field human body, has been developed to calculate region interest. The simulation tool provides graphic user interface. In case denervation lower extremities, an target muscle is m. quadriceps femoris. potential distribution along its fibers...

Abstract: Finite difference models of the human thigh are used to analyze excitation process in fibers denervated skeletal muscles conjunction with functional electrical stimulation (FES) via surface electrodes. The Matlab tool “FES‐Analyze” was developed simulate and super‐threshold regions a thigh. Action potential is simulated muscle fiber model Hodgkin Huxley type generalized form activating function. With FES‐Analyze it possible compare at end central part fiber, both cross‐...