Nanomedicines are applied as alternative treatments for anticancer agents. For the treatment of cancer, due to small size in nanometers (nm), specific site targeting can be achieved with use nanomedicines, increasing their bioavailability and conferring fewer toxic side effects. Additionally, minute amounts drugs lead cost savings. In addition, nanotechnology is effectively preparation such they nm sizes, considered one earliest cutoff values production products utilized nanotechnology....

Conventional formulations of antiviral drug acyclovir have various limitations such as low bioavailability. The current study was aimed at developing polymeric matrices for the controlled delivery using sericin polymer and acrylic acid (AA) a monomer. free radical polymerization technique used hydrogel formulation. Briefly, chemically cross-linked with acid. N′-N′-methylene bis-acrylamide (MBA) ammonium persulfate (APS) were cross-linker initiator, respectively. FTIR spectra showed that...

Madecassoside, a triterpenoid saponin compound mainly isolated from the gotu kola herb (Centella asiatica), shows an extensive range of biological activities, including antiapoptotic, antioxidant, anti-inflammatory, moisturizing, neuroprotective, and wound healing effects. It has been highly used in management eczema, skin wounds, other diseases. Due to poor oral bioavailability, membrane permeability, intestinal absorption, clinical application madecassoside is limited. Hence, drug carrier...

The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has posed significant challenges to global health since its onset in December 2019. While numerous models have been developed predict outcomes, many fall short accurately forecasting mortality rates, focusing instead on clinical severity. This study addresses these gaps proposing an advanced approach using Recurrent Neural Networks (RNNs) improve prediction. Although existing employed various machine learning (ML) and deep (DL)...

This study investigates pH-sensitive hydrogels based on biocompatible, biodegradable polysaccharides and natural polymers such as chondroitin sulfate alginate in combination with synthetic monomer acrylic acid, controlled drug carriers. Investigations were conducted for sulfate/alginate-graft-poly(acrylic acid) hydrogel various mixing ratios of sulfate, acid the presence ammonium persulfate N',N'-Methylene bisacrylamide. Crosslinking loading confirmed by Fourier transform infrared...

This study aims to determine the nitrate exposure and their health assessment in spring water used for drinking Harnai. Total 24 samples were collected from four springs drinking. Three starting point three end of each collected. DR/890 multi-parameter portable calorimeter was measurement nitrate. The concentration ranged 0.1 1.1 mg/l with an average 0.389 mg/l. results show that is 93%, 99% less than permissible limits recommended by Pakistan Standards & Quality Control Authority (PSQCA)...

The purpose of this study is to estimate the concentrations radon and heavy metals in drinking water assess their health implications population Quetta, Pakistan. concentration was measured collected from tube wells different depths Balochistan, Pakistan, using RAD7 detector Atomic Absorption Spectrometer, respectively. results show that ranged 3.56 ± 0.98 8.56 1.32Bq/L with an average 5.67 1.34Bq/L. value contribution indoor air found 2.02 0.47mBq/L. In addition water, physiochemical...

Smart and intelligent xanthan gum/pluronic F-127 hydrogels were fabricated for the controlled delivery of atomoxetine HCl. Different parameters such as DSC, TGA, FTIR, XRD, SEM, drug loading, porosity, swelling index, release, kinetics modeling appraised prepared matrices hydrogels. FTIR confirmed successful synthesis hydrogel, while TGA DSC analysis indicated that thermal stability reagents was improved after polymerization technique. SEM revealed hard surface XRD a reduction in...

Aim and Objective: The aim of this study was to prepare polyvinyl alcohol/acrylic acid (PVA/AA) hydrogels for the controlled release diclofenac sodium as carriers overcome not only side effects but also sustain its an extended period. Background: Diclofenac is employed relieving pain fever. half-life very short (1-2 h). Hence, multiple intakes are required maintain a constant pharmacological action. Multiple GI adverse produced result intake Methods: A free radical polymerization technique...

Introduction Colorectal cancer is the third most common type of in world and Pakistan it ranks at fifth position. The present study was conducted to evaluate knowledge, attitude, preventive practices perceived barriers screening about colorectal among university students. Method A cross-sectional after developing a self-administered questionnaire students newly merged districts Kpk, Result total 302 (232 male 70 female) participated study. knowledge score participants regarding risk factors...

Abstract Data on environmental contamination of the parasites zoonotic importance is scarce in Pakistan. Soil with feces dogs hide infective stages parasite represents a health-risk to humans. This study was aimed assess eggs gastrointestinal stray and household lower Dir district, Pakistan special consideration those that can be spread One hundred fifty two stool specimens from (stray dogs=90 dogs=62) were collected. The helminth processed by direct smear method centrifugation techniques...

Abstract The purpose of this pilot study was to explore the efficacy, safety, and tolerability vidofludimus calcium (VC) in treatment primary sclerosing cholangitis (PSC). This a single‐arm open‐label with cohort 18 patients PSC. Study received VC for period 6 months. undertaken at two sites, Mayo Clinic, Rochester, MN, Phoenix, AZ. endpoint improvement serum alkaline phosphatase (ALP) end study. Secondary endpoints included assessment other liver biomarkers (bilirubin, alanine...

Acetaminophen is a white crystalline odorless drug. It decreases the formation of prostaglandins by inhibiting cyclooxygenase enzyme (COX-3), thus, used in relieving pain and fever. The recommended dose acetaminophen very high. Due to high intake, certain severe adverse effects such as hepatotoxicity skin rashes are produced. Thus, drug carrier system needed sustain release also enhance patient compliance. Therefore, current study was focused on development new delivery based polyethylene...

This research paper presents the novelty of a new Na-Bentonite-graft-acrylamide/acrylic acid superabsorbent composite material that has high water absorbency and whose graft ratios were established by graft-copolymerizing acrylamide, acrylic acid, Sibi Bentonite together in an aqueous solution. Fourier Transform Infra-Red Spectroscopy (FTIR), X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Thermogravimetric Analyzer (TGA) employed to determine shape, thermal stability,...

Markhor (Capra Falconeri), is notably endangered ungulate native to the northern mountains of Chitral, Pakistan, specifically within Chitral Goal National Park and Tooshe Shaha Conservancy Area (TSC), facing a serious threat from gastrointestinal (GI) parasites. These parasites adversely affect health Markhor, resulting in pathological immunological degeneration. The conservation plan for further complicated by climate change, introducing challenges, particularly terms hunting trophies. This...