A5051422895- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Neuroendocrine Tumor Research Advances
- Hormonal and reproductive studies
- Gestational Diabetes Research and Management
- Adrenal Hormones and Disorders
- Thyroid Disorders and Treatments
- Estrogen and related hormone effects
- Sexual Differentiation and Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Ophthalmology and Eye Disorders
- Glioma Diagnosis and Treatment
- Lipid metabolism and disorders
- Pancreatic function and diabetes
- Genetic Syndromes and Imprinting
- Pancreatic and Hepatic Oncology Research
- Neuroblastoma Research and Treatments
- Folate and B Vitamins Research
- Diet and metabolism studies
- Diabetes and associated disorders
- Thyroid Cancer Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Prenatal Screening and Diagnostics
- Pharmacological Effects and Assays
Hospital Universitario Dexeus
2014-2023
USP Institut Universitari Dexeus
2005-2013
Hospital Universitari Germans Trias i Pujol
2012
Universitat de Barcelona
2007
Massachusetts General Hospital
1999-2004
Harvard University
2000-2004
Hospital Clínic de Barcelona
1995-2002
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2000
Brigham and Women's Hospital
2000
Nutrition & Santé (Spain)
2000
Androgen deficiency in women is increasingly recognized as a new clinical syndrome and has raised our awareness of the importance accurate well-validated measurements serum free testosterone (T) concentrations women. Therefore, we compared T levels measured by equilibrium dialysis to those direct RIA (analog method) calculated from law mass action (requires measurement total SHBG). We also androgen index, 100 x T/SHBG, simple index known correlate with T. Subjects were 147 variable estrogen...
Background: Growth hormone–deficient adults have increased cardiovascular mortality. hormone replacement may affect risk. Inflammation plays an important role in atherosclerosis, and inflammatory markers are predictive of events. Objective: To investigate the effect growth on other risk factors. Design: Randomized, single-blind, placebo-controlled trial. Patients: 40 men with adult-onset deficiency. Intervention: or placebo given for 18 months at a dose adjusted normal serum insulin-like...
Androgen deficiency in men is associated with severe osteopenia, alterations body composition including an increase fat mass, and decreased libido. Little known about the pathophysiology, metabolic consequences, or gender-specific effects of androgen women. Acquired hypopituitarism women characterized by central hypogonadism and/or hypoadrenalism therefore may affect critical sources production We hypothesized that serum levels would be hypopituitarism. determined 55 92 controls. This...
Acromegaly is associated with premature cardiovascular mortality. GH replacement therapy decreases inflammatory markers of risk, but little known about these in patients acromegaly. The receptor antagonist, pegvisomant, reduces IGF-I levels 98% treated. We investigated the effects blockade on and other risk active Forty-eight acromegaly 47 age- body mass index-matched controls were included. study consisted 3 parts: a cross-sectional study, prospective randomized 12-wk placebo-controlled...
Abstract Adults with acquired GH deficiency (GHD) have been shown to osteopenia associated a 3-fold increase in fracture risk and exhibit increased body fat decreased lean mass. Replacement of results mass, bone mineral density (BMD). The possible differential effect withdrawal replacement on composition compartments regional mass is not known. We performed randomized, single blind, placebo-controlled 36-month cross-over study vs. placebo (PL) adults GHD now report the percent fat, density,...
OBJECTIVE: To investigate the frequencies of major maturity-onset diabetes young (MODY) subtypes in a panel Spanish families and to assess phenotypic differences patients with different MODY. METHODS: Forty-eight subjects from twenty clinical diagnosis MODY were studied. They underwent standardised examination 75-g oral glucose tolerance test (OGTT) was performed. Estimations insulin sensitivity (%S) secretion capacity (%B) calculated by computer-solved homeostasis model assessment (HOMA)....
Patients with hypopituitarism have increased cardiovascular mortality. A high prevalence of conventional risk factors, including obesity, central fat distribution, insulin resistance, and dyslipidemia, been described in these patients. The inflammatory markers C-reactive protein (CRP) IL-6 are predictors events, levels CRP reported men GH deficiency. However, little is known about women hypopituitarism. We therefore investigated whether traditional elevated Fifty-three 111 healthy control...
Context: Fibromyalgia (FM) is characterized by widespread pain and fatigue considered a syndrome with different pathogenic mechanisms. Controversial data on GH axis disturbances have been published. Some preliminary trials shown promising effects of therapy tender points quality life in FM.
Data on the prevalence of benign and malignant nodular thyroid disease in patients with acromegaly is a matter debate. In last decade an increasing incidence cancer has been reported. The aim this study was to evaluate goiter, nodules large series cross-sectional control group. Six Spanish university hospitals participated. One hundred twenty three (50% men; mean age 59±13 years; duration 6.7±7.2 years) 50 controls (51% males, 58±15 were studied. All participants underwent ultrasound fine...
Functional defects in growth hormone (GH) secretion and its efficacy as a complementary treatment have been suggested for fibromyalgia. This study investigated the safety of low-dose GH an add-on therapy patients with both severe FM low insulin-like factor 1 levels. A total 120 were enrolled multicenter, placebo-controlled 18 months. They randomly assigned to receive either 0.006 mg/kg/day subcutaneously (group A, n=60) or placebo B, 6 months (blind phase). The arm was switched from month 12...
GH deficiency is associated with increased cardiovascular mortality and early manifestations of atherosclerosis. Elevated serum homocyst(e)ine levels have been found to be risk. The effect replacement on has not investigated date. We evaluated the fasting homocyst(e)inemia in a group men adult-onset randomized, single blind, placebo-controlled trial.
Abstract The proper clinical approach to a wide range of disorders relies on the availability accurate, reproducible laboratory results for sexual steroids measured using methods with high specificity and sensitivity. chemiluminescent immunoassays currently available have analytical limitations significant implications. This position statement reviews current techniques measurement estradiol testosterone their impact diverse scenarios. A set recommendations are provided incorporate steroid...
Leptin is an adipose tissue hormone whose plasma levels reflect energy stores. Although pathological thyroid function related to changes in expenditure and body composition, its possible influence on leptin remains be determined. The objective of the study was provide new data relationship between function. Sixteen patients with primary autoimmune hypothyroidism, seventeen hyperthyroidism were prospectively studied from time clinical diagnosis then every 6-8 weeks until completely restored...
Excess GH secretion, as occurs in acromegaly, is associated with abnormalities bone turnover markers and mineral density (BMD). administration deficient patients causes an increase turnover. IGF-I mediates many of the metabolic actions GH, although may have direct effects upon bone. In acromegaly who are treated a receptor antagonist, selective blockade results decrease circulating levels majority cases. We hypothesized that, antagonism receptors would result serum turnover, including...
Pegvisomant is an effective treatment for acromegaly.To investigate escape (loss of biochemical control in patients previously controlled) and lipodystrophy acromegalic treated with pegvisomant to evaluate possible associations clinical features.Multicentre retrospective study involving 19 Spanish centres.Ninety-seven were included (59% women, mean age at diagnosis 42 ± 13 years, 80% macroadenomas); follow-up on was 5 2·5 89 (92%) achieved normal IGF-1. Escape reported 30/89 (34%)...
OBJECTIVE: To investigate the effect of intravenous insulin therapy combined with nicotinamide in metabolic control and beta-cell function newly diagnosed type 1 diabetic subjects comparison intensive alone. RESEARCH DESIGN AND METHODS: A total 34 patients were included. After correction initial disturbances, randomly assigned to following three groups within 72 h after admission: 1) + placebo (C) (n = 12); 2) nicotinamide, 700 mg times a day (NIC) 11); 3) 72-h followed by (NIV) 11). The...
The usefulness of the acute octreotide test in selection acromegalic patients for chronic somatostatin depot analogues treatment is controversial. aim present study was to determine its accuracy response prediction, and reliability a short version classic 6-hour test. data from 26 acromegalics (19 women, 7 men, mean age 52.6±13.1 years) studied with an (6 hours sampling GH measurement after 100 μg s. c.) were retrospectively analyzed. Eighteen them followed 12 months. nadir always detected...
Patients with hypopituitarism have increased cardiovascular mortality. A high prevalence of conventional risk factors, including obesity, central fat distribution, insulin resistance, and dyslipidemia, been described in these patients. The inflammatory markers C-reactive protein (CRP) IL-6 are predictors events, levels CRP reported men GH deficiency. However, little is known about women hypopituitarism.