A5031339607- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Glioma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood properties and coagulation
- Adrenal Hormones and Disorders
- Meningioma and schwannoma management
- Thyroid Disorders and Treatments
- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Inflammatory Biomarkers in Disease Prognosis
- Iron Metabolism and Disorders
- Ophthalmology and Eye Disorders
- TGF-β signaling in diseases
- Neonatal and fetal brain pathology
- Bipolar Disorder and Treatment
- Heart rate and cardiovascular health
- Heart Rate Variability and Autonomic Control
- MicroRNA in disease regulation
- Psychology and Mental Health
- Prostate Cancer Diagnosis and Treatment
- Hormonal and reproductive studies
- Nuclear Structure and Function
Hospital Universitari i Politècnic La Fe
2016-2025
Hospital Universitari Germans Trias i Pujol
2012
Universidade Federal do Rio Grande do Norte
2001
Few data exist about the clinical course of acromegaly, surgical and medical outcomes in patients with GH- prolactin cosecreting pituitary adenomas (GH&PRL-PAs). Nevertheless, some series described a more aggressive clinic-radiological behavior than growth hormone-secreting (GH-PAs).
Pharmacologic treatment of acromegaly is currently based upon assay-error strategy, the first-generation somatostatin receptor ligands (SRL) being first-line treatment. However, about 50% patients do not respond adequately to SRL. Our objective was evaluate potential usefulness different molecular markers as predictors response We used somatotropinoma tissue obtained after surgery from a national cohort 100 acromegalic patients. Seventy-one were treated with SRL during at least 6 months...
The outcomes of transsphenoidal surgery (TSS) for pituitary adenoma (PA) depend on many factors, including the availability an expert team and volume surgeries performed. Data TSS PA are scarce in our country. TESSPAIN evaluates Spanish centers to assess influence surgical specialized neurosurgical teams success complication rates. A retrospective, nationwide, study performing between January 2018 December 2022. Centers were classified as high (HV) [n=11, defined with recognized expertise...
Pituitary apoplexy (PA) is a rare and acute condition resulting from hemorrhage or infarction of the pituitary gland. This study aimed to assess clinical characteristics, management, outcomes PA in patients aged <65 ≥65 years using data Spanish multicenter cohort. We conducted retrospective, (2010-2023) 301 18 hospitals. Data were analyzed for differences demographics, presentation, treatment approach, outcomes. Patients (n=116, 38.5%) had more comorbidities, compared younger (n=185, 61.5%)....
Abstract Context Medical treatment of acromegaly is currently performed through a trial-and-error approach using first-generation somatostatin receptor ligands (fgSRLs) as first-line drugs, with an effectiveness about 50%, and subsequent drugs are indicated clinical judgment. Some biomarkers can predict fgSRLs response. Objective Here we report the results ACROFAST study, trial in which protocol based on predictive was evaluated. Methods This prospective (21 university hospitals) comparing...
Abstract Predicting which acromegaly patients could benefit from somatostatin receptor ligands (SRL) is a must for personalized medicine. Although many biomarkers linked to SRL response have been identified, there no consensus criterion on how assign this pharmacologic treatment according biomarker levels. Our aim provide better predictive tools an accurate patient stratification regarding the ability respond SRL. We took advantage of multicenter study 71 and we used advanced mathematical...
Hyperintensity signal in T2-weighted magnetic resonance imaging (MRI) has been related to better therapeutic response during pasireotide treatment acromegaly. The aim of the study was evaluate T2 MRI intensity and its relation with effectiveness real-life clinical practice.Retrospective multicentre including acromegaly patients treated pasireotide. Adenoma at diagnosis qualitatively classified as iso-hyperintense or hypointense. Insulin-like growth factor (IGF-I), hormone (GH) tumour volume...
Epigenetic alterations may play a role in the development and behavior of pituitary neuroendocrine tumors (PitNETs). To evaluate effect methylation tumor suppressor genes (TSGs) on their gene expression PitNETs. We used methylation-specific multiplex ligation-dependent probe amplification quantitative real-time PCR techniques to analyze DNA-promoter hypermethylation 35 TSGs 105 defined functionality, size, invasiveness according clinical manifestations, Hardy's classification, MRI cavernous...
There are few studies on haemorheological disturbances in morbidly obese patients. The role played by the metabolic syndrome rheological profile of subjects has not yet been established, and it is clear whether obese, but "metabolically healthy", show alterations. We aimed to determine whole 136 patients normo-weight volunteers, along with plasma lipids, inflammatory insulin resistance parameters. Patients had statistically higher glucose, triglycerides, HbA1c, leptin, insulin, HOMA, CRP,...
Subclinical hypothyroidism (SCH) has been suggested to be associated with increased cardiovascular risk by different mechanisms. Several factors have analysed, but yielded controversial results.We aimed analyse whether there are differences in several markers, such as lipids, inflammatory parameters: plasma viscosity (PV), fibrinogen and C reactive protein (CRP); homocysteine (Hcy) red blood cell distribution width (RDW), when comparing SCH controls. We also analysed which of these...
Acromegaly is caused by excess growth hormone (GH) produced a pituitary tumor. First-generation somatostatin receptor ligands (SRLs) are the first-line treatment. Several studies have linked E-cadherin loss and epithelial-mesenchymal transition (EMT) with resistance to SRLs. Our aim was study EMT its relationship SRLs in GH-producing tumors. We analyzed expression of EMT-related genes RT-qPCR 57 The postsurgical response categorized as complete response, partial or nonresponse if IGF-1...
Some reports suggest that acromegaly in elderly patients has a more benign clinical behavior and could have better response to first-generation long-acting somatostatin receptor ligands (SRL). However, there is no specific therapeutic protocol for this special subgroup of patients.This study aimed at identifying predictors SRL patients.Multicentric retrospective nationwide diagnosed with or over the age 65 years.One-hundred eighteen (34 men, 84 women, mean diagnosis 71.7 ± 5.4 years old)...
Aim The WHO Classification of Tumours Endocrine Organs considers the inmunohistochemical characterization pituitary adenomas (PA) as mandatory for patient diagnosis. Recent advances in knowledge molecular patterns these tumours could complement this classification with gene expression profiling. Methods Within context Spanish Molecular Registry Pituitary Adenomas (REMAH), a multicentre clinical-basic research project, we analysed phenotype 142 PAs complete IHC and clinical information. Gene...
Pegvisomant is an effective treatment for acromegaly.To investigate escape (loss of biochemical control in patients previously controlled) and lipodystrophy acromegalic treated with pegvisomant to evaluate possible associations clinical features.Multicentre retrospective study involving 19 Spanish centres.Ninety-seven were included (59% women, mean age at diagnosis 42 ± 13 years, 80% macroadenomas); follow-up on was 5 2·5 89 (92%) achieved normal IGF-1. Escape reported 30/89 (34%)...
The aim of the present study is to check whether we can replicate, in an independent series, previous results showing that molecular pituitary-specific gene expression complements inmunohistochemical identification pituitary neuroendocrine tumours. We selected 112 patients (51 (46.4%) women; mean age 51.4±16 years; 102 macroadenomas (91.9%), 9 microadenomas (8.1%)) with complete clinical, radiological, immunohistochemical and data from our set Patients were different those previously...
The classification of pituitary neuroendocrine tumors (PitNETs) subtypes continues generating interest. In 2017, the World Health Organization (WHO) proposed considering immunohistochemical (IHC) analysis pituitary-specific transcription factors (TF) for their typification. present study targeted quantification TF (TPIT, PIT-1, SF-1, GATA2, ESR1) gene expression by RT-qPCR to overcome shortcomings IHC and complement it. We analyzed 251 from our collection PitNETs performed additional studies...
There are no data on mortality of acromegaly diagnosed in older individuals.This work aimed to compare clinical characteristics, growth hormone-related comorbidities, therapeutic approaches, and rate patients before or after 2010 assess overall compared with the general Spanish population.A retrospective evaluation was conducted among tertiary care centers 118 at age 65 older. Kaplan-Meier curves were constructed trace survival, Cox proportional hazard models used risk factors associated...