A5004536495- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Nutrition and Health in Aging
- Adrenal and Paraganglionic Tumors
- Clinical Nutrition and Gastroenterology
- Diabetes Management and Research
- Diabetes Treatment and Management
- Glioma Diagnosis and Treatment
- Nuclear Structure and Function
- Blood disorders and treatments
- Immunodeficiency and Autoimmune Disorders
- Meningioma and schwannoma management
- Liver Disease Diagnosis and Treatment
- Adrenal Hormones and Disorders
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Gestational Diabetes Research and Management
- Head and Neck Surgical Oncology
- Child Nutrition and Feeding Issues
- Pregnancy and preeclampsia studies
- Electrolyte and hormonal disorders
- Body Composition Measurement Techniques
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Dysphagia Assessment and Management
- Childhood Cancer Survivors' Quality of Life
Complejo Hospitalario Universitario de Santiago
2008-2025
Instituto de Investigación Sanitaria de Santiago
2019-2024
Universidade de Santiago de Compostela
2008-2023
Complexo Hospitalario Universitario A Coruña
2020
Complejo Asistencial Universitario de Palencia
2014-2019
Servicio Gallego de Salud
2019
Hospital de León
2012-2017
Universidad de León
2017
Abstract Background Obesity has increased in recent years with consequences on diabetes and other comorbidities. Thus, 1 out of 3 diabetic patients suffers cardiovascular disease (CVD). The network among glucose, immune system, endothelium epicardial fat an important role pro-inflammatory thrombotic mechanisms atherogenesis. Since semaglutide, long-acting glucagon like peptide 1- receptor agonist (GLP-1-RA), a glucose-lowering drug, reduces body weight, we aimed to study its effects human...
Abstract Context Medical treatment of acromegaly is currently performed through a trial-and-error approach using first-generation somatostatin receptor ligands (fgSRLs) as first-line drugs, with an effectiveness about 50%, and subsequent drugs are indicated clinical judgment. Some biomarkers can predict fgSRLs response. Objective Here we report the results ACROFAST study, trial in which protocol based on predictive was evaluated. Methods This prospective (21 university hospitals) comparing...
The outcomes of transsphenoidal surgery (TSS) for pituitary adenoma (PA) depend on many factors, including the availability an expert team and volume surgeries performed. Data TSS PA are scarce in our country. TESSPAIN evaluates Spanish centers to assess influence surgical specialized neurosurgical teams success complication rates. A retrospective, nationwide, study performing between January 2018 December 2022. Centers were classified as high (HV) [n=11, defined with recognized expertise...
Pituitary apoplexy (PA) is a rare and acute condition resulting from hemorrhage or infarction of the pituitary gland. This study aimed to assess clinical characteristics, management, outcomes PA in patients aged <65 ≥65 years using data Spanish multicenter cohort. We conducted retrospective, (2010-2023) 301 18 hospitals. Data were analyzed for differences demographics, presentation, treatment approach, outcomes. Patients (n=116, 38.5%) had more comorbidities, compared younger (n=185, 61.5%)....
Abstract Background The aim of our study was to validate the classification proposed by PANOMEN-3 group for prediction tumor recurrence/progression in pituitary tumors (PTs). Methods Multicenter national case-control patients with PTs followed at least 5 years. Kaplan-Meier curves were used assess time recurrence/progression. Uni- and multivariate Cox regression analyses estimate hazard ratio [HR] prognostic capacity group. Findings A total 1143 included. Pituitary surgery performed 814...
Abstract Context Ectopic acromegaly is a consequence of rare neuroendocrine tumors (NETs) that secrete GHRH. This abnormal GHRH secretion drives GH and IGF-1 excess, with clinical presentation similar to classical pituitary acromegaly. Identifying the underlying cause for hypersecretion in setting ectopic excess is, however, essential proper management both NET. Owing rarity NETs, imaging characteristics have not been analyzed depth large series. Objective Characterize magnetic resonance...
The tall cell variant (TCV) of papillary thyroid carcinoma (PTC) is characterized by columnar cells with a height at least three times their width. TCV usually presents an older age, has larger size and exhibits more extrathyroidal extension metastases than classical PTC. current study compared the follicular variants (CaFVs) PTC to determine if, irrespective age diagnosis tumor size, aggressive its counterparts. A total 16 (3.66%) patients were identified in series 437 from Clinical...
Some reports suggest that acromegaly in elderly patients has a more benign clinical behavior and could have better response to first-generation long-acting somatostatin receptor ligands (SRL). However, there is no specific therapeutic protocol for this special subgroup of patients.This study aimed at identifying predictors SRL patients.Multicentric retrospective nationwide diagnosed with or over the age 65 years.One-hundred eighteen (34 men, 84 women, mean diagnosis 71.7 ± 5.4 years old)...
Rathke’s cleft cysts (RCC) are a common type of lesion found in the sellar or suprasellar area. They usually monitored clinically, but some cases, surgery may be required. However, their natural progression is not yet well understood, and outcomes uncertain. The objective this study to evaluate history patients who clinically without treatment, determine incidence recurrences over time. Design National multicentric diagnosed cyst (RCC- Spain) from 2000 onwards followed 15 tertiary centers...
Pituitary apoplexy (PA) is the paradigm of endocrine and neurosurgical emergency.
There are no data on mortality of acromegaly diagnosed in older individuals.This work aimed to compare clinical characteristics, growth hormone-related comorbidities, therapeutic approaches, and rate patients before or after 2010 assess overall compared with the general Spanish population.A retrospective evaluation was conducted among tertiary care centers 118 at age 65 older. Kaplan-Meier curves were constructed trace survival, Cox proportional hazard models used risk factors associated...
Acromegaly is produced by excess growth hormone secreted a pituitary adenoma of somatotroph cells (ACRO). First-line therapy, surgery and adjuvant therapy with somatostatin analogs, fails in 25% patients. There no predictive factor resistance to therapy. New therapies are investigated using few dispersed tumor acute primary cultures standard conditions where the do not grow, or rat cell lines that maintain full phenotype. The RET/PIT1/p14ARF/p53 pathway regulates apoptosis normal...
<b><i>Background:</i></b> Craniopharyngioma (CP) is a rare tumor in the elderly whose clinical features and prognosis are not well known this population. <b><i>Aim:</i></b> To evaluate clinicopathological therapeutic outcomes of CP diagnosed elderly. <b><i>Patients Methods:</i></b> This was retrospective, multicenter, national study patients over age 65 years surgically treated....