Miguel Paja
A5001234098- Adrenal and Paraganglionic Tumors
- Thyroid Cancer Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Hormonal Regulation and Hypertension
- Adrenal Hormones and Disorders
- Growth Hormone and Insulin-like Growth Factors
- Neuroendocrine Tumor Research Advances
- Parathyroid Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Thyroid Disorders and Treatments
- Glioma Diagnosis and Treatment
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neuroblastoma Research and Treatments
- Radiation Dose and Imaging
- Electrolyte and hormonal disorders
- Ophthalmology and Eye Disorders
- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Ovarian cancer diagnosis and treatment
- S100 Proteins and Annexins
- Global Cancer Incidence and Screening
- Pancreatic and Hepatic Oncology Research
- Diet and metabolism studies
- Head and Neck Surgical Oncology
- Radiomics and Machine Learning in Medical Imaging
Hospital de Basurto
2016-2025
University of the Basque Country
2017-2025
Osakidetza
2019-2022
Endocrinology Research Center
2013
Hospital Universitario Puerta de Hierro Majadahonda
1993
Few data exist about the clinical course of acromegaly, surgical and medical outcomes in patients with GH- prolactin cosecreting pituitary adenomas (GH&PRL-PAs). Nevertheless, some series described a more aggressive clinic-radiological behavior than growth hormone-secreting (GH-PAs).
The outcomes of transsphenoidal surgery (TSS) for pituitary adenoma (PA) depend on many factors, including the availability an expert team and volume surgeries performed. Data TSS PA are scarce in our country. TESSPAIN evaluates Spanish centers to assess influence surgical specialized neurosurgical teams success complication rates. A retrospective, nationwide, study performing between January 2018 December 2022. Centers were classified as high (HV) [n=11, defined with recognized expertise...
Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy with high risk of postoperative recurrence. Although adjuvant mitotane commonly used, its potential for achieving cure rather than simply postponing inevitable recurrence remains uncertain. This study investigates whether impacts ACC patterns by preventing or delaying retrospective analysis used data from the ICARO-GETTHI/SEEN registry, which includes 36 Spanish hospitals. Recurrence in non-metastatic patients after resection...
The aim of this study was to evaluate the prevalence autonomous cortisol secretion (ACS) in patients with primary aldosteronism (PA) and its implications on cardiometabolic surgical outcomes.This is a retrospective multicenter PA who underwent 1 mg dexamethasone-suppression test (DST) during diagnostic workup 21 Spanish tertiary hospitals. ACS defined as post-DST >1.8 µg/dL (confirmed if >5 possible 1.8-5 µg/dL) absence specific clinical features hypercortisolism. profile compared control...
Purpose Population-based and registry studies have shown that chronic hypoparathyroidism is accompanied by long-term complications. We aimed to evaluate the risk of incident comorbidity among patients with postsurgical in real-life clinical practice Spain. Methods performed a multicenter, retrospective cohort study including lasting ≥3 years at least follow-up visit between January 1, 2022 September 15, 2023 (group H). The prevalence incidence complications kidney disease,...
Patients with obesity have an overactivated renin-angiotensin-aldosterone system (RAAS) that is associated essential hypertension. However, the influence of in primary aldosteronism (PA) unknown.We analyzed effect on characteristics PA, and association between RAAS components.A retrospective study was conducted Spanish PA Registry (SPAIN-ALDO Registry), which included patients seen at 20 tertiary centers 2018 2022. Differences without were analyzed.A total 415 included; 189 (45.5%) obesity....
Purpose To compare the clinical and hormonal characteristics of patients with familial hyperaldosteronism (FH) sporadic primary aldosteronism (PA). Methods A systematic review literature was performed for identification FH patients. The SPAIN-ALDO registry cohort no suspicion chosen as comparator group (sporadic group). Results total 360 (246 type I, 73 II, 29 III, 12 IV) cases 830 PA were included. Patients FH-I younger than cases, women more commonly affected (P = 0.003). In addition,...
To develop a predictive model of hypertension resolution after adrenalectomy in patients with primary aldosteronism (PA), based on their presurgical characteristics.A retrospective multicenter study PA follow-up 20 Spanish tertiary hospitals between 2018 and 2021 was performed (SPAIN-ALDO Register). Clinical response postadrenalectomy classified according to the surgical outcome (PASO) consensus criteria. The developed using multivariate logistic regression estimation all possible...
Pituitary adenomas (PA) are rare in young patients, and additional studies needed to fully understand their pathogenesis this population. We describe the clinical genetic characteristics of apparently sporadic PA a cohort patients.Clinical molecular analysis 235 patients (age ≤ 30 years) with PA. Clinicians from several Spanish Chilean hospitals provided data.Genetic screening was performed via next-generation sequencing comparative genomic hybridization array. Clinical variables were...
There are no data on mortality of acromegaly diagnosed in older individuals.This work aimed to compare clinical characteristics, growth hormone-related comorbidities, therapeutic approaches, and rate patients before or after 2010 assess overall compared with the general Spanish population.A retrospective evaluation was conducted among tertiary care centers 118 at age 65 older. Kaplan-Meier curves were constructed trace survival, Cox proportional hazard models used risk factors associated...
Central adrenal insufficiency (AI) due to isolated adrenocorticotropic hormone (ACTH) deficiency (IAD) has been recently associated with immune checkpoint inhibitor (ICI) therapy. Our aim was analyze the prevalence, clinical characteristics, and therapeutic outcomes in cancer patients IAD induced by ICI A retrospective multicenter study performed. From a total of 4447 treated antibodies, 37 (0.8%) (23 men (62.2%), mean age 64.7 ± 8.3 years (range 46-79 years)) were diagnosed IAD. The tumor...
To evaluate the diagnostic accuracy of 131I-6β-iodomethyl-19-norcholesterol (NP-59) adrenal scintigraphy for subtyping diagnosis primary aldosteronism (PA), considering as gold standard unilateral PA (UPA), either results venous sampling (AVS) or outcome after adrenalectomy.A retrospective multicenter study was performed on patients from 14 Spanish tertiary hospitals who underwent NP-59 with an available diagnosis. Patients were classified UPA if biochemical cure achieved adrenalectomy...
The objective of the study was to evaluate efficacy second-line therapies in patients with acromegaly caused by a growth hormone (GH) and prolactin (PRL) co-secreting pituitary neuroendocrine tumor (GH&PRL-Pit-NET) compared their GH-secreting (GH-Pit-NET). This is multicenter retrospective on treatment pasireotide and/or pegvisomant. Patients were classified two groups: GH&PRL-Pit-NETs when evidence hyperprolactinemia immunohistochemistry (IHC) for GH PRL positive or if >200 ng/dL regardless...
Purpose The identification of patients with chronic hypoparathyroidism who are adequately (AC) or not controlled (NAC) has clinical interest, since poor disease control is related to complications and mortality. We aimed assess the prevalence NAC in a cohort subjects postsurgical hypoparathyroidism. Methods performed multicenter, retrospective, study including from 16 Spanish hospitals lasting ≥3 years. analyzed biochemical profile wellness. For assessment we considered three criteria:...
To compare the presentation and evolution of primary aldosteronism (PA) in elderly (≥65 years) young patients (<65 years).A retrospective multicenter study was performed 20 Spanish hospitals PA follow-up between 2018 2021.Three hundred fifty-two with <65 years 88 ≥65 were included. Older had a two-fold higher prevalence type 2 diabetes, dyslipidemia, cerebrovascular disease, but these differences disappeared after adjusting for hypertension duration. At diagnosis, diastolic blood pressure...